Publications by authors named "Kai Wei"
Dissociation, characterized by altered consciousness and perception, underlies multiple mental disorders, but the specific neuronal subtypes involved remain elusive. In mice, we find that dissociation-inducing doses of ketamine significantly inhibit retrosplenial cortex (RSC) parvalbumin interneurons (PV-INs), enhancing delta oscillations (1-3 Hz) and delta-gamma phase-amplitude coupling (δ-γ PAC) and inducing dissociation-like behaviors. Optogenetic inhibition of RSC PV-INs triggers delta oscillations, δ-γ PAC, and some dissociation-like behaviors without ketamine.
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- The study investigates HIPK3 DNA methylation as a potential biomarker for rheumatoid arthritis (RA) and its relationship with clinical indicators in multiple rheumatic diseases.
- Researchers analyzed methylation levels in 368 participants, using advanced sequencing technology, and discovered that HIPK3 methylation was significantly lower in RA, systemic lupus erythematosus (SLE), and dermatomyositis (DM) compared to healthy controls.
- Findings indicate a negative correlation between HIPK3 methylation levels and various clinical markers in RA, suggesting HIPK3 hypomethylation could serve as a diagnostic indicator for RA and related diseases.
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- Drought stress significantly hinders plant growth, and this study focuses on how the wild tomato Solanum chilense adaptively responds to it in arid environments in South America.
- Through transcriptome analysis under varying conditions, researchers identify two main gene networks involved in drought response: one regulating the cell cycle, which is older and more stable, and another related to metabolism, which is newer and more variable.
- The integration of population genomics shows that older genes under positive selection are more interconnected in these networks, suggesting that adaptations to drought stress first occur in key genes, leading to changes that may contribute to species evolution and colonization of drier areas.
Unlabelled: Duck circovirus (DuCV) is widely recognized as a prominent virus in China's duck farming industry, known for its ability to cause persistent infections and significant immunosuppression, which can lead to an increased susceptibility to secondary infections, posing a significant threat to the duck industry. Moreover, clinical evidence also indicates the potential vertical transmission of the virus through duck embryos to subsequent generations of ducklings. However, the limited availability of suitable cell lines for cultivation of DuCV has hindered further investigation into the molecular mechanisms underlying its infection and pathogenicity.
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- Rheumatoid arthritis (RA) is an autoimmune disease that leads to inflammation of the joints, primarily driven by fibroblast-like synoviocytes (FLS) which produce inflammatory substances like TNF-α and IL-6.
- FLS in RA behave similarly to tumors, proliferating aggressively and resisting cell death, contributing to joint damage.
- Targeting E3 ubiquitin ligases like cIAP2 may offer potential treatments for RA by reducing inflammation and FLS survival, though the potential side effects of these treatments need further investigation.