Publications by authors named "Kai Waldrant"
Article Synopsis
- The rise of single-cell analysis tools makes benchmarks crucial for guiding analysis and method improvement.
- Current benchmarks suffer from issues like lack of standardization and limited adaptability, affecting their usefulness over time.
- Open Problems is introduced as a dynamic, community-driven benchmarking platform that addresses these issues by encompassing 10 current single-cell tasks to enhance method selection and evaluation.
Article Synopsis
- Researchers are focusing on new methods to prevent and eliminate biofilms due to their increased resistance to disinfectants and antibiotics.
- In past studies, a structure called 5-aryl-2-aminoimidazole was found to effectively prevent biofilm formation across various bacteria and fungi.
- The study involved synthesizing 48 dimers of this compound, with variations in their structure, and many showed enhanced anti-biofilm activity, particularly against bacteria like Salmonella and E. coli, without affecting their growth in free-floating (planktonic) forms.
We previously synthesized several series of compounds, based on the 5-aryl-2-aminoimidazole scaffold, that showed activity preventing the formation of Salmonella enterica serovar Typhimurium and Pseudomonas aeruginosa biofilms. Here, we further studied the activity spectrum of a number of the most active N1- and 2N-substituted 5-aryl-2-aminoimidazoles against a broad panel of biofilms formed by monospecies and mixed species of bacteria and fungi. An N1-substituted compound showed very strong activity against the biofilms formed by Gram-negative and Gram-positive bacteria and the fungus Candida albicans but was previously shown to be toxic against various eukaryotic cell lines.
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