Publications by authors named "Kai Robin Pfeifer"
Eur J Immunol
February 2023
Article Synopsis
- Primary and recurrent cytomegalovirus (CMV) infections can lead to CMV colitis, affecting both immunocompromised individuals and those with inflammatory bowel disease (IBD), with rare instances in immunocompetent patients.
- A study using a mouse model showed that acute primary MCMV infection changes gut microbial composition and leads to significant replication of the virus in the colon, along with increased inflammation and cell growth in the intestinal lining.
- The research found that CMV directly infects intestinal cells, causing increased cell death and disrupting the epithelial barrier, suggesting that CMV can temporarily cause colitis by disturbing the gut's balance in healthy individuals.
