LZ-R-5 Ameliorates DSS-Induced Colitis in Mice by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function.

LZ-R-5 (R-5), a strain with high epithelial adhesion and bioactive exopolysaccharide production, was isolated from Tibetan kefir grains. This study investigated its potential to alleviate intestinal inflammation using a DSS-induced colitis model in BALB/c mice. We integrated microbial diversity and serological analyses to assess changes in gut flora and cytokines following the R-5 treatment.

Impact of extreme temperature on congenital heart disease mortality: a population-based nationwide case-crossover study.

Background: The association between congenital heart disease (CHD) and non-optimal temperatures has received limited investigation. We aimed to investigate the impact of extreme temperatures on CHD mortality.

Methods: We reviewed the National Mortality Surveillance System of China and retrieved death records attributable to CHD from 2013 to 2021.

DEHP-mediated oxidative stress leads to impaired testosterone synthesis in Leydig cells through the cAMP/PKA/SF-1/StAR pathway.

Leydig cells (LCs) injury is often irreversible upon discovery; hence, early identification of risk factors for injury is crucial. The ubiquitous plasticizer di-2-ethylhexyl phthalate (DEHP) in the environment has been shown to potentially cause damage to LCs. However, the underlying mechanisms remain unclear.

Adjuvant Immunotherapy Does Not Improve Survival in Non-small Cell Lung Cancer with Major/Complete Pathological Response after Induction Immunotherapy.

Objective: In patients with resectable non-small cell lung cancer (NSCLC), immune checkpoint inhibitor (ICI)-based regimens in both neoadjuvant and perioperative settings demonstrate survival benefit. To date, no study has compared the efficacy between pure neoadjuvant and perioperative approaches, especially in patients who achieve substantial pathological responses.

Methods: In this retrospective study, patients with clinical stage II-IIIB NSCLC who achieved either major (MPR) or complete (pCR) pathological response after induction ICI plus chemotherapy followed by resection between 2019 and 2023 were identified from multicenter databases.

The global regulator SpoVG is involved in biofilm formation and stress response in foodborne Staphylococcus aureus.

Staphylococcus aureus (S. aureus) is a primary culprit of food poisoning. As a highly adaptable pathogen, S.

Uniportal Robotic Lobectomy and Lymphadenectomy for Invasive Lung Cancer: A Novel Approach and Perioperative Outcomes.

Background: Multiport robot-assisted thoracoscopic surgery (mRATS) has been comprehensively evaluated for its clinical efficacy in numerous studies. Nevertheless, the safety and feasibility of uniportal robotic lobectomy and lymphadenectomy require further validation.

Methods: The clinical data of 34 consecutive patients with lung cancer who underwent improved uniportal robotic-assisted thoracoscopic surgery (uRATS) at our hospital between November 2023 and June 2024 were reviewed retrospectively.

Optical genome mapping reveals maternal mosaicism in two Sibling cases of Early-Onset Facioscapulohumeral muscular dystrophy type 1.

Background: Facioscapulohumeral muscular dystrophy (FSHD) is an autosomal dominant condition caused by shortened D4Z4 repeat units in the subtelomeric region of 4q35, always on the 4qA haplotype, or due to variants in the SMCHD1 gene leading to hypomethylation of the D4Z4 macrosatellite DNA repeats.

Methods: To explore the potential genetic basis for suspected FSHD presenting with early onset in two siblings without evident family history of the disorder, whole genome sequencing (WGS) and optical genome mapping (OGM) were conducted on the affected individuals and their parents.

Results: The two siblings manifested severe and early-onset clinical features consistent with FSHD, initiating with facial muscle weakness that progressively spread downward since the age of four months.

Effectiveness and safety of vonoprazan and amoxicillin dual regimen with Saccharomyces boulardii supplements on eradication of Helicobacter pylori.

Background: Currently, Vonoprazan (VPZ) and amoxicillin dual regimen (VA-dual) has not achieved satisfied efficacy as the first-line treatment for Helicobacter pylori (H. pylori) infection in China. Thus, we aimed to determine the effect of VA-dual plus Saccharomyces boulardii (S.

Circulating levels of blood biomarkers and risk of benign prostatic hyperplasia: Results from two large cohorts in Europe and East Asia.

Background: As one of the most prevalent chronic non-communicable diseases affecting aging males, the burden of benign prostatic hyperplasia is growing over the world. Our study aims at investigating the potential relationships between various blood biomarkers and benign prostatic hyperplasia (BPH) in middle-aged and older men in European and East Asian population cohorts.

Methods: We included 229 022 male adults from the UK Biobank (UKB) and 20 284 male adults from the China Health and Retirement Longitudinal Study (CHARLS) in this study.

Bioactive glass suspension hydrogel promotes wound healing by modulating fibroblasts.

The irritation and adhesion of wound healing biomaterials to wet wounds should be addressed for achieving effective wound healing. In this study, a stable multifunctional hydrogels (BGs/HA suspension gels) were prepared using superfine powder of bioactive glasses (BGs), the biocompatible materials hyaluronic acid (HA) and carbomer940, which had good adhesion and low irritation properties for use in moist complex wounds. The average particle size of BGs/HA suspension gels was 13.

Turnkey generation of MIR soliton and NIR second-harmonic microcombs.

Mid-infrared (MIR) microcombs exhibit remarkable advantages for trace molecule detection, facilitating fast and precise spectral analysis. However, due to limitations in tunability and size of available MIR pump sources, it is difficult to achieve compact MIR mode-locked microcombs using traditional methods. Here, we propose the turnkey generation of MIR soliton and near-infrared second-harmonic microcombs in a single microresonator.

Hydrocyclone-induced classification reduction and spin desorption of contaminated soil remediation with heavy metal and organics.

The correlation between soil pollutant concentration and particle size in multi-component contaminated soil containing Cadmium (Cd) and Polychlorinated biphenyls (PCBs) has been investigated. The hydrocyclone classification process has been utilized to reduce the amount of contaminated soil, followed by the application of the hydrocyclone leaching process for the remediation of residual contamination. The results of the hydrocyclone classification process revealed that smaller soil particles have higher concentrations of Cd and PCBs, consistent with the findings from the soil sieving process.

Revisiting the Exposed Surface Characteristics on the Stability and Photoelectric Properties of MAPbI.

CHNHPbI (MAPbI), as a promising candidate of photovoltaic materials, has attracted extensive interests due to its excellent photoelectric properties and low preparation cost. However, the relationship between synthesis parameter and performance is still unclear due to the overlook of exposed surface characteristics, limiting the mass-production and commercialization of MAPbI. Therefore, it is necessary to clarify the stability and photoelectric properties of different exposed surfaces of MAPbI under humid environment.

[Influence of Typical Regional Land Use/Landscape Pattern on Water TN of the Upper Yellow River].

This study aimed to explore the relationship between land use landscape pattern and water quality in the upstream of the Gansu water conservation, water and soil erosion, and ecological fragile areas. Based on the land use data and water quality monitoring section in 2020 in the 200 m, 500 m, 1 km, 2 km, 50 km, and 10 km riparian buffer area, the single-factor index evaluation method, random forest regression model, and BP neural network were used to quantify the response relationship between land use and landscape pattern of the upper Yellow River in Gansu province and water quality index and to carry out the basin water quality prediction based on land use landscape index data. The results showed that： ① through the single-factor index method, the major indicators of the total nitrogen （TN） in July and September, dissolved oxygen （DO）, permanganate index, ammonia nitrogen （NH -N）, total phosphorus （TP）, and other surface indexes met the surface water environment class Ⅲ water quality standard.

Biodiversity of mudflat intertidal viromes along the Chinese coasts.

Viruses constitute the most diverse and abundant biological entities on Earth. However, our understanding of this tiniest life form in complex ecosystems remains limited. Here, we recover 20,102 viral OTUs from twelve intertidal zones along the Chinese coasts.

Effects of breast-fed infants-derived and ameliorate DSS-induced colitis in mice.

Studies have shown that breastfeeding can reduce the risk and severity of inflammatory bowel disease (IBD) in children and adults. Probiotics in breast milk have also been isolated and their effects on IBD have been studied. However, based on current evidence, the exact efficacy and mechanisms of probiotics in the treatment of IBD cannot be determined.

Clinical Treatment Progress for Large Metacarpal and Phalangeal Bone Defects.

Large metacarpal and phalangeal bone defects are a hot topic for orthopedic surgeons due to its high clinical incidence, disability rate, and postsurgical amputation rate, along with its difficult treatment, long treatment course, high cost, and poor effect, all of which have a negative impact on the appearance and function of the patient's hands. There are currently a variety of treatment options for large metacarpal and phalangeal bone defects, each with its own benefits and drawbacks. However, there is no treatment method capable of perfectly resolving all the problems of patients with these defects.

Vitamin drinks improve palatability and reduce adverse events associated to polyethylene glycol electrolyte solutions.

Background: The unpleasant taste of polyethylene glycol (PEG) has been a hindrance to patients undergoing colonoscopy.

Aim: This study aims to determine whether the addition of a vitamin drink (Mizone) to the 4L split-dose PEG regimen would be effective in improving the solution's palatability, and reducing patient discomfort during bowel preparation.

Methods: The present prospective, single endoscopist-blinded, randomized controlled study randomly assigned patients into two groups: PEG + Mizone group (3.

Intergenerational continuation of parent-child separation and 1-year telomere length attrition among mother-offspring dyads in rural China: The moderating effects of resilience.

Background: Although stressor exposure early in life was known risk factor for telomere length (TL) attrition, limited literature explored it across generations. Furthermore, the effects of resilience have rarely been examined. Here, we examined whether the effects of intergenerational parent-child separation on offspring 1-year TL attrition vary by the levels of resilience.

mA reader YTHDF2 orchestrates CD8 T cell infiltration to promote pancreatic cancer progression and predicts clinical outcome.

Pancreatic cancer has emerged as one of the most lethal malignancies, characterized by rising morbidity and mortality rates. Research has demonstrated that N6-methyladenosine (mA) modification of RNA significantly influences RNA metabolism, and dysregulation of mA is implicated in various human diseases. A clearer picture of how the divergent mA methylation patterns affect immunological microenvironment in pancreatic cancer is still unknown.

Fully recyclable and tough thermoplastic elastomers from simple bio-sourced δ-valerolactones.

While a large number of chemically recyclable thermoplastics have been developed in recent years, technologically important thermoplastic elastomers (TPEs) that are not only bio-based and fully recyclable but also exhibit mechanical properties that can rival or even exceed those petroleum-based, non-recyclable polyolefin TPEs are critically lacking. The key challenge in developing chemically circular, bio-based, high-performance TPEs rests on the complexity of TPE's block copolymer (BCP) structure involving block segments of different suitable monomers required to induce self-assembled morphologies responsible for performance as well as the control and monomer compatibility in their synthesis and the selectivity in their depolymerization. Here we demonstrate the utilization of bio-sourced δ-valerolactone (δVL) and its simple α-alkyl-substituted derivatives to produce all δVL-based polyester tri-BCP TPEs, which exhibit not only complete (closed-loop) chemical recyclability but also excellent toughness that is 2.

Nitrogen fixation by alkali and alkaline earth metal hydrides assisted by plasma.

The chemical behaviors of alkali and alkaline earth metal hydrides including LiH, KH, MgH, CaH, and BaH under nitrogen plasma differ significantly from one another, exhibiting an ammonia production trend that contrasts with that observed under thermal conditions. A prominent feature of KH is its ability to facilitate plasma-assisted N fixation without generating H byproduct, showing high atomic economy in utilization of hydride ions for N reduction.