Publications by authors named "Kai Kelly"
Article Synopsis
- The current gold standard for testing human islet or stem cell-derived β-like cell function involves implanting them in immunodeficient mice, but existing models have limitations like unstable hyperglycemia and high morbidity.
- Researchers developed the IsletTester mouse using CRISPR-Cas9 to create a stable hyperglycemic model, showing normal life span and fertility with consistent glucose levels.
- This new model allows for better study of human islet biology and serves as a valuable preclinical tool for evaluating stem cell-derived islet products.
