Genomic, transcriptomic, and metabolomic analyses reveal convergent evolution of oxime biosynthesis in Darwin's orchid.

Angraecum sesquipedale, also known as Darwin's orchid, possesses an exceptionally long nectar spur. Charles Darwin predicted the orchid to be pollinated by a hawkmoth with a correspondingly long proboscis, later identified as Xanthopan praedicta. In this plant-pollinator interaction, the A.

Biomimetic Honeycomb-like TiCT MXene/Bacterial Cellulose Aerogel-Based Flexible Pressure Sensor for the Human-Computer Interface.

The pursuit of efficient and accurate human-computer interface design urgently requires high-performance sensors with pressure sensitivity, a wide detection range, and excellent cycling stability. Herein, a biomimetic honeycomb-like TiCT MXene/bacterial cellulose (BC) aerogel with a negative Poisson's ratio (ν = -0.14) synthesized from the bidirectional freeze-drying method is used as the active material for a flexible pressure sensor, which exhibits high sensitivity (20.

Effect of bismuth on the microstructural evolution and properties of single-crystal Fe during rolling: a molecular dynamics study.

Context: Bi-containing free-cutting steel has consistently attracted attention in the field of materials processing. The molecular dynamics (MD) simulations were used to investigate the impact of bismuth (Bi) nanoparticles on the internal structural evolution and mechanical properties of single-crystal Fe during the rolling process. The influence of varying rolling depths in the presence of nanoparticles is also examined.

NH-MIL-125(Ti)/TiO heterojunction with non-disturbed dual reactive centers for synchronous photocatalytic removal of Cr(VI) and organic dyes.

Chromium (VI) (Cr(VI)) generally coexists with organic dyes in industrial effluents, posing a formidable challenge in water purification. Herein, NH-MIL-125(Ti)/TiO Z-scheme heterojunction with intimate interfacial contact was synthesized for synchronous removal of pollutant in coexisting Cr(VI)/dyes system under simulated solar irradiation. Structural and optical investigations indicated that a well-defined interface was formed by establishing a Ti-N-C bond, facilitating the spatial separation of the photoexcited carriers of the Z-scheme heterojunction.

Narrowing and blue-shifting photoluminescence of carbon dots by enhancing sp-C hybridization using a microreactor.

Effectively narrowing and blue-shifting photoluminescence (PL) of carbon dots (CDs) through enhancing their sp-C hybridization degree by using a microreactor are achieved. The resulting CDs emit ultraviolet (UV) PL centered at 345 nm with a full width at half maximum (FWHM) of 54 nm, with blue-shift of over 100 nm and FWHM narrowed by nearly half in comparison with that of the CDs prepared by using the traditional solvothermal method.

APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs.

Tumor suppressor protein Adenomatous polyposis coli protein (APC) is an EB-binding and microtubule (MT) plus end-tracking protein; however, how exactly APC regulates MT dynamics remains elusive. Here, we show that in LLC-PK1 cells, APC and KIF2A, an MT depolymerase, form a complex clustering at the cell edge and destabilize MTs at the MT plus ends. Further biochemical characterization and mutational analysis reveal key residues for the APC-KIF2A interaction.

High-Performance Solution-Processable Organic Light-Emitting Diode Based on a Narrowband Near-Ultraviolet Emitter and a Hot Exciton Strategy.

Achieving high efficiency narrowband near-ultraviolet (NUV) emitters in organic light emitting diode (OLED) is still a formidable challenge. Herein, a proof-of-concept hybridized local and charge transfer (HLCT) molecule, named ICz-BO, is prepared and characterized, in which both multiresonant (MR) skeletons are integrated via conjugation connection. A slightly distorted structure and weak intramolecular charge transfer (CT) interaction between two MR subunits lead to a high-lying reverse intersystem crossing (h-RISC) channel of T→S, also evidenced by both experimental and calculated results.

A multitask interpretable model with graph attention mechanism for activity prediction of low-data PIM inhibitors.

The aberrant expression of proviral integration site for Moloney murine leukemia virus (PIM) kinases is closely related to various tumors and chemotherapy resistance, making them attractive targets for cancer therapy. However, due to the extremely high homology among the three PIM isoforms (PIM1, PIM2, PIM3) and the limited availability of existing bioactivity data, screening and designing selective PIM inhibitors remain a daunting challenge. To address this issue, this study constructed a multitask regression model that can simultaneously predict the half-maximal inhibitory concentration (IC values).

Bismuth oxychloride-bismuth oxide hybrid as a high-capacity anode material for aqueous alkaline battery.

A high-capacity and rate capability anode material is highly desired to improve the export performance of aqueous alkaline batteries (AABs). Due to the 3-electrons redox chemistry within a wide negative potential range, bismuth (Bi) based compounds are promising candidates as anode materials in AABs. A hybrid composed of different Bi-based compounds is envisioned to further reinforce the faradaic activity and affinity for electrolyte ions, thereby maximizing the charge storage capacity.

Anti-breast cancer effects of dairy protein active peptides, dairy products, and dairy protein-based nanoparticles.

Breast cancer is the most frequently diagnosed and fatal cancer among women worldwide. Dairy protein-derived peptides and dairy products are important parts of the daily human diet and have shown promising activities in suppressing the proliferation, migration, and invasion of breast cancer cells, both and . Most of the review literature employs meta-analysis methods to explore the association between dairy intake and breast cancer risk.

Impact of bone metastasis on prognosis in non-small cell lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.

Background: Lung cancer is a leading cause of cancer-related deaths globally, with non-small cell lung cancer (NSCLC) accounting for approximately 85% of cases. While immune checkpoint inhibitors (ICIs) have transformed treatment for advanced NSCLC, the role of bone metastasis in modulating ICI efficacy remains unclear. Bone metastasis, occurring in 30-40% of advanced NSCLC cases, is associated with worse outcomes.

Phase behavior of symmetric diblock copolymers under 3D soft confinement.

The phase behavior of symmetric diblock copolymers under three-dimensional (3D) soft confinement is investigated using self-consistent field theory. Soft confinement is realized in binary blends composed of AB diblock copolymers and C homopolymers, where the copolymers self-assemble to form a droplet embedded in a homopolymer matrix. The phase behavior of the confined block copolymers is regulated by the degree of confinement and the selectivity of the homopolymers, resulting in a rich variety of novel structures.

Performance improvement of triple-doped nanocomposite membrane towards hairwork dyeing effluent reclamation approaching zero liquid discharge.

It is highly anticipated that efforts will be made to raise the level of industrial effluent reclamation on the background of continuously minimizing waste stream based on preconcentration tool. For this purpose, a triple-doped nanocomposite (TFN-tri) membrane through partially alternative doping spiro-structured 2,2'-dimethyl-1,1'-biphenyl-4,4'-diamine dihydrochloride and flexible 4,4'-bipiperidyl dihydrochloride and continuous incorporating of molybdenum disulfide quantum dots was successfully fabricated. With the assistance of self-synthesized biodegradable flocculant pretreatment, raw hairwork dyeing effluent (HDE) was stably recycled up to 95.

Ultra-rapid Synthesis of High-entropy MAX Phases and Their Derivative MXenes for Battery Electrodes.

High-entropy materials hold immense promise for energy storage, owing to their varied compositions and unforeseen physicochemical properties, yet, which poses challenges in synthesis due to tendentious phase separation and extended sintering durations. Herein, an ultra-rapid strategy based on spark plasma sintering (SPS) techniques is proposed to synthesize high-entropy MAX phases within 15 minutes, including a new phase of (TiVCrNbMo)AlC and several phases of 413-type TiVNbMoAlC, TiVCrMoAlC and (TiVCrNbTa)AlC, achieving utmost purity level up to 99.54 %.

Comparative Study on Protein Composition and Foam Characteristics of Barley and Wheat Beer.

Protein is an important component of beer, and its type, content and molecular weight directly affect the quality of beer, especially the foam quality of beer. Different brands of wheat beer and barley beer available in the market were used for this analysis. The differences in protein composition and foam performance between multi-sample barley and wheat beer were analyzed using sodium dodecyl sulfate-polyacrylamide gel electrophoresis and high-pressure size exclusion chromatography.

Performance of the Flash10 COVID-19 point-of-care molecular test.

After the COVID-19 pandemic, fever clinics urgently require rapid nucleic acid tests to enhance their capacity for timely pathogen detection. This study evaluated the analytical performance and clinical utility of the Flash10 SARS-CoV-2 point-of-care test (Flash10 POCT) for detecting SARS-CoV-2 in patients with fever in the adult fever clinic in Beijing Tsinghua Changgung Hospital from August 1 to August 30, 2023. The analytical performance and clinical utility of the Flash10 POCT for detecting SARS-CoV-2 were assessed in 125 patients with fever syndrome in the adult fever clinic.

Nucleation and phase transition of decagonal quasicrystals.

In this work, we study the nucleation of quasicrystals from liquid or periodic crystals by developing an efficient order-order phase transition algorithm, namely, the nullspace-preserving saddle search method. In particular, we focus on nucleation and phase transitions of the decagonal quasicrystal (DQC) based on the Lifshitz-Petrich model. We present the nucleation path of DQC from the liquid and demonstrate one- and two-stage transition paths between DQC and periodic crystals.

Picolinic acid promotes organic pollutants removal in Fe(III)/periodate process: Mechanism and relationship between removal efficiency and pollutant structure.

The application of Fe-catalyzed periodate (PI) processes is often limited by both the narrow applicable pH range and weak reaction between Fe(III) and oxidant. Here, the biodegradable picolinic acid (PICA) was used as one kind of chelating ligands (CLs) to enhance the removal of organic pollutants (OPs) at initial pH 3.0-8.

Liquid Bi-Sb-Sn Electrodes with Synergistic Stabilization Mechanism for Long-Lifespan Sodium-Based Liquid Metal Batteries.

Sodium-based liquid metal batteries are well suited for stationary energy storage due to their long life, intrinsic safety, and ease of scale-up. However, the irreversible alloying reaction between the positive current collector (PCC) and the cathodes at high temperatures leads to severe capacity degradation of the battery, severely limiting its scale-up application. In this work, a Bi-Sb-Sn alloy cathode based on a synergistic stabilization mechanism was designed for the first time.

Analysis of risk factors for intraoperative bleeding in patients with Siewert type II esophagogastric junction adenocarcinoma treated by two minimally invasive surgeries and its influence on prognosis: a retrospective study.

Background: The present study aimed to analyze the independent risk factors for intraoperative bleeding in Siewert II adenocarcinoma of the esophagogastric junction (AEG) using two minimally invasive surgical approaches, namely, the laparoscopy-assisted abdominal trans-hiatal (LTH) method and transthoracic-laparoscopic esophagectomy (TLE).

Methods: The clinical data of 100 patients with SiewertII AEG admitted to our hospital from October 2017 to October 2020 were retrospectively analyzed. According to the type of surgery, the patients were divided into LTH approach group and TLE approach group.

A Respiratory Sensor-Based Study of the Relationship between Voluntary Breathing Patterns and Aerobic and Anerobic Exercise Capacity-An Exploratory Applied Study.

(1) Background: Exploring the relationship between spontaneous breathing patterns and aerobic and anerobic running exercise performance can greatly improve our understanding of optimizing physical fitness. Spontaneous breathing patterns refer to how the rhythm and depth of breathing affect performance and physical adaptation during exercise. (2) Methods: This study aimed to investigate this relationship by enrolling 240 college students (120 males and 120 females, aged 18-22).