Publications by authors named "Kai H Griebenow"
The folate receptor alpha (FR), which is overexpressed in solid tumors including NSCLC, can be utilized for active tumor targeting to afford more effective cancer therapies. In this context, cytochrome c (Cyt c) has drawn attention to cancer research because it is non-toxic, yet, when delivered to the cytoplasm of cancer cells, can kill them by inducing apoptosis. Cyt c nanoparticles (NPs, 169 ± 9 nm) were obtained by solvent precipitation with acetonitrile, and stabilized by reversible homo-bifunctional crosslinking to accomplish a Cyt-c-based drug delivery system that combines stimulus-responsive release and active targeting.
View Article and Find Full Text PDFMalignant gliomas are the most lethal form of primary brain tumors. Despite advances in cancer therapy, the prognosis of glioma patients has remained poor. Cytochrome c (Cytc), an endogenous heme-based protein, holds tremendous potential to treat gliomas because of its innate capacity to trigger apoptosis.
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- The study reports the first successful total synthesis of ω-phenyl Δ6 fatty acids (FAs) and evaluates their cytotoxic effects on A549 cancer cells and leishmanicidal properties against Leishmania infantum.
- Novel compounds, including 16-phenyl-6-hexadecynoic acid (1), showed significant cytotoxicity, with 1 having the highest potency (IC50 of 18 μM) against A549 cells.
- Both 1 and 2 displayed effective antileishmanial activity but did not induce apoptosis in A549 cells, indicating alternative cell death mechanisms, and showed low toxicity toward normal murine splenocytes, making them promising candidates for further research.