Publications by authors named "Kai Chit Cheung"
Article Synopsis
- - Alternative splicing includes microexons in neuronal proteins, which are often linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
- - A specific 24-nucleotide microexon in the RNA-binding protein CPEB4, previously shown to be less included in individuals with ASD, plays a critical role in regulating gene expression linked to neurodevelopment.
- - The study finds that this microexon helps maintain the flexible regulation of CPEB4 during neuronal activation by preventing its aggregation, allowing it to switch from repressing to activating translation of genes.
The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are preferentially activated by hypo-osmolality, have been implicated in various physiological functions. Deficiency of these channels would cause many diseases including hearing loss. However, their structures and physiological roles are not yet well understood.
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