Outcome of carbapenem or colistin resistant Klebsiella pneumoniae bacteremia in the intensive care unit.

Carbapenem-resistant Klebsiella pneumoniae (CRKp) infections continue to be an important cause of mortality. In this retrospective study, the effect of carbapenem or colistin resistance on mortality in Klebsiella pneumoniae bacteremia and combined meropenem + colistin administration in CRKp bacteremia was evaluated. In addition to that, a mathematical model is applied to explore the relationships between the resistance and mortality.

A comparative study of ceftazidime/avibactam-based and fosfomycin plus meropenem-based regimens for managing infections caused by carbapenem-resistant in critically ill patients.

The main aim of this study was to compare and analyze the effectiveness of treatment regimens using ceftazidime/avibactam (CAZ/AVI) versus fosfomycin plus meropenem (FOS/MER) for managing bloodstream infections (BSI) or ventilator-associated pneumonia (VAP) caused by carbapenem-resistant (CRKP) in critically ill patients. Between 4 January 2019, and 16 July 2023, adult patients (≥18 years old) diagnosed with BSI or VAP due to culture confirmed CRKP in ICU of a tertiary care hospital were investigated retrospectively. A total of 71 patients were categorized into two groups: 30 patients in CAZ/AVI-based, and 41 patients in FOS/MER-based group.

Parenteral nutrition consensus report from KEPAN.

Objectives: Medical nutrition therapy is one of the core components of patient management, although its implication is still limited in Daily practice globally. Clinicians are in need of guidance that will ease the application of medical nutrition therapy. The pre- and post-graduate curriculum for medical nutrition therapy is limited in most regions, worldwide.

Sepsis episodes caused by pressure injuries in critical illness: a retrospective observational cohort study.

Background: Critically-ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs).

Purpose: To identify predisposing factors and discuss diagnosis and management of sepsis-related PIs in CIPs.

Methods: The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis-diagnoses and with different site cultures that were positive concurrent with bloodstream-cultures were retrospectively reviewed.

OXA-48 Dominance Meets Ceftazidime-Avibactam: A Battle Against Life-Threatening Carbapenem-Resistant Klebsiella pneumoniae Infections in the Intensive Care Unit.

Objective In this study, we aimed to describe the outcomes in ICU patients with bloodstream infection (BSI) or ventilatory-associated pneumonia (VAP) due to carbapenem-resistant (CRKP) who received ceftazidime-avibactam treatment at a tertiary care university hospital. Methods Patients aged 18 years or older who were admitted to the Anesthesiology and Reanimation ICU at Bursa Uludag University Faculty of Medicine Hospital between June 13, 2021, and July 16, 2023, and diagnosed with BSI or VAP due to CRKP were included in this study. Results A total of 42 patients treated with ceftazidime-avibactam were included.

Evaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae.

Objective: The aim of this study was to evaluate the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae infections in a tertiary-care center.

Methods: Between December 24, 2018 and November 21, 2022, adult patients diagnosed with bloodstream infection or ventilator-associated pneumonia due to culture-confirmed carbapenem-resistant Klebsiella pneumoniae in the anesthesiology and reanimation intensive care units were investigated retrospectively.

Results: There were a total of 62 patients fulfilling the study inclusion criteria.

The effect of music on delirium, pain, sedation and anxiety in patients receiving mechanical ventilation in the intensive care unit.

Objectives: To examine the effects of music for patients under mechanical ventilation support in the intensive care unit on their delirium, pain, sedation, and anxiety.

Research Methodology/design: A single-blind, randomized, controlled trial.

Setting: The study was conducted with delirium positive patients between August 2020 and September 2021 in the medical/surgical intensive care unit of a university hospital in Turkey.

Incidence, characteristics and risk factors of delirium in the intensive care unit: An observational study.

Aims And Objective: To investigate the incidence, characteristics and risk factors of delirium in the ICU.

Background: Identifying the risk factors of delirium is important for early detection and to prevent adverse consequences.

Design: An observational cohort study conducted according to STROBE Guidelines.

Prognostic Risk Factors in Ventilator-Associated Pneumonia.

BACKGROUND Ventilator-associated pneumonia (VAP) is a nosocomial infection commonly seen in patients in intensive care units (ICU). This study aimed to analyze factors affecting prognosis of patients diagnosed with VAP. MATERIAL AND METHODS Critically ill patients with VAP were retrospectively evaluated between June 2002 and June 2011 in the ICU.

Nosocomial Acinetobacter pneumonia: Treatment and prognostic factors in 356 cases.

Background And Objective: Acinetobacter baumannii and A. baumannii/calcoaceticus complex are commonly encountered pathogens in nosocomial infections. This study aimed to evaluate the treatment and prognostic risk factors in nosocomial pneumonia caused by these microorganisms.

A retrospective evaluation of critically ill patients infected with H1N1 influenza A virus in Bursa, Turkey, during the 2009-2010 pandemic.

Background: H1N1 influenza A virus infections were first reported in April 2009 and spread rapidly, resulting in mortality worldwide. The aim of this study was to evaluate patients with H1N1 infection treated in the intensive care unit (ICU) in Bursa, Turkey.

Methods: Demographic characteristics, clinical features, and outcome relating to H1N1 infection were retrospectively analysed in patients treated in the ICU.

Comparison of blood culture and multiplex real-time PCR for the diagnosis of nosocomial sepsis.

Background: In many cases of suspected sepsis, causative microorganisms cannot be isolated. Multiplex real-time PCR generates results more rapidly than conventional blood culture systems.

Methods: In this study, we evaluated the diagnostic performance of multiplex real-time PCR (LightCycler® SeptiFast, Roche, Mannheim, Germany), and compared with blood cultures and cultures from focus of infection in nosocomial sepsis.

Guillain-Barré Syndrome and Human Immunodeficiency Virus.

Guillain-Barré syndrome (GBS) is an acute disease characterised by symmetrical muscle weakness, loss of sensation and reflex. There is usually a viral infection at the beginning of the disease. Here, we report a GBS case which did not respond to any treatment strategy at first and was diagnosed as Human Immunodeficiency Virus positive (HIV+) during the search for the aetiology.

Comparison of SPECT findings and neuropsychological sequelae in carbon monoxide and organophosphate poisoning.

Abnormal regional cerebral blood flow in patients with acute carbon monoxide (CO) and organophosphate (OP) poisoning was examined using (99m)Tc-hexamethylpropylene amine oxime (HMPAO) brain single photon emission computed tomography (SPECT) in fourteen patients. We evaluated the predictive significance of acute phase brain SPECT findings for long-term neuropsychological sequelae. Changes were found in the frontal, temporal, parietal lobes within the first week after both types of poisoning.

[The use of the laryngeal mask airway and the cuffed oropharyngeal airway during percutaneous tracheostomy].

Background: The aim of our study is to compare the safety and efficiency of the use of the laryngeal mask airway (LMA) and the cuffed oropharyngeal airway (COPA) with the use of endotracheal tube (ETT) for maintain patent airway during percutaneous tracheostomy (PCT).

Methods: The patients were randomly assigned to LMA group (n=35, M/F; 28/7, age; 52 [18-79]), COPA group (n=31, M/F; 23/8, age; 57 [18-80]) and ETT group (n=30, M/F; 22/8, age; 49 [18-80]) with respect to use of LMA, COPA and ETT in order to maintain patent airway during PCT procedure. PT was performed as described by Griggs et al.

Persistence of candiduria in ICU catheterized patients is not linked to adherence and proteolytic activities of Candida strains.

Objective: In this study, the patients who developed asymptomatic candiduria in the intensive care unit were followed prospectively for the persistence of candiduria after the replacement of indwelling urethral catheter and the correlation between persistence and virulence factors (proteinase enzyme activity and epithelial adhesion) was assessed.

Design: Prospective study.

Setting: Intensive care unit and mycology laboratory at a university hospital.

Tc-99 HMPAO cerebral SPECT imaging in brain death patients with complex spinal automatism.

Background: The aim of this study is to evaluate the value ofTc-99 HMP AO cerebral SPECT imaging to confirm brain death in patients with complex spinal automatism.

Methods: Fifteen patients (8 female, 7 male) aged between 1,5-48 years showing spinal movements within 24-72 hours after brain death were examined with Tc-99 HMPAO cerebral SPECT.

Results: All patients demonstrated empty skull on Tc-99 HMPAO images and no contradictory case was ob- served between standard clinical criteria and SPECT study.