Partial cooling of the upper body with a water-cooled vest in an environment exceeding body temperature.

Objectives: To evaluate the efficacy of water-cooled clothing that continuously cools restricted body areas to suppress body temperature increase as an anti-heatstroke measure for workers in hot environments that exceed body temperature.

Methods: Ten healthy men were placed in Room A (air temperature: 25°C, relative humidity: 50%) for 15 min. They were then transferred to Room B (air temperature: 40°C, relative humidity: 50%), where they rested for 10 min, then put on cooling clothing, and again rested for 15 min (the control group rested for 25 min).

Mitigation of heat strain by wearing a long-sleeve fan-attached jacket in a hot or humid environment.

Objectives: This study examined whether a fan-attached jacket (FAJ) may mitigate the heat strain in hot or humid environment.

Methods: Nine healthy men engaged in 60-min sessions on a bicycle ergometer (4 metabolic equivalents [METs] workload) in hot-dry (40°C and 30% relative humidity) and warm-humid (30°C and 85% relative humidity) environments. Both are equivalent to an approximately 29°C wet-bulb globe temperature.

A fan-attached jacket worn in an environment exceeding body temperature suppresses an increase in core temperature.

We examined whether blowing hot air above body temperature under work clothing may suppress core temperature. Nine Japanese men engaged in two 30-min bicycle ergometer sessions at a workload of 40% VOmax at 40 °C and 50% relative humidity. The experiment was conducted without wearing any cooling apparatus (CON), wearing a cooling vest that circulated 10.

Inflammation-Induced Attenuation of Prostaglandin D Elimination across Rat Blood-Brain Barrier: Involvement of the Downregulation of Organic Anion Transporter 3 and Multidrug Resistance-Associated Protein 4.

Prostaglandin (PG) D is a lipid mediator, and in the brain, overproduction of PGD is reportedly involved in the progression and exacerbation of neuroinflammation. The objective of this study was to elucidate PGD efflux transport, under normal and inflammatory conditions, across the blood-brain barrier (BBB), which is formed by brain capillaries. Elimination of [H]PGD across the BBB of normal and lipopolysaccharide (LPS)-induced inflammatory rats was examined by the intracerebral microinjection technique.