Publications by authors named "Kahona Zushi"
Article Synopsis
- - The study reveals that myogenic stem satellite cell activator HGF experiences nitration due to peroxynitrite, leading to its diminished binding to the receptor c-met, which disrupts muscle health as we age.
- - A specific rat anti-HGF monoclonal antibody, 1H41C10, effectively protects HGF from nitration at critical tyrosine sites (Y198 and Y250), maintaining its function to activate satellite cells.
- - The findings suggest that 1H41C10 could be significant in developing treatments for age-related muscle loss and conditions like sarcopenia by preventing HGF dysfunction.
Mechanical perturbation triggers activation of resident myogenic stem cells to enter the cell cycle through a cascade of events including hepatocyte growth factor (HGF) release from its extracellular tethering and the subsequent presentation to signaling-receptor c-met. Here, we show that with aging, extracellular HGF undergoes tyrosine-residue (Y) nitration and loses c-met binding, thereby disturbing muscle homeostasis. Biochemical studies demonstrated that nitration/dysfunction is specific to HGF among other major growth factors and is characterized by its locations at Y198 and Y250 in c-met-binding domains.
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