Publications by authors named "Kaho Arai"

Article Synopsis
  • - Hemolysis-induced acute kidney injury (AKI) results from damage to proximal tubule epithelial cells (PTECs) caused by heme and the formation of tubular casts; megalin, a receptor in PTECs, plays a key role in this process by facilitating the uptake of hemoglobin and heme-scavenging proteins.
  • - Researchers studied the role of megalin in hemolysis-induced AKI using mice with targeted megalin knockout, discovering that megalin deficiency reduces the uptake of harmful proteins but increases tubular cast formation, indicating a complexity in protein reabsorption mechanisms.
  • - The study explored cilastatin, a megalin blocker, as a potential therapy and found that it reduces
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The development of fluorescence switchable molecules in several polar and apolar environments has been required for fluorescence imaging of nanostructures. Photochromic molecules are an important class for the reversible light-triggered fluorescence switching. Although many studies of fluorescence switching by using photochromic reactions have been reported, the report of photochromic molecules reversibly showing turn-on mode fluorescence switching has been limited in spite of their importance.

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