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Publications by authors named "Kahnie Pham-Kaplita"

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BR96 conjugates of highly potent anthracyclines.
H Dalton King Andrew J Staab Kahnie Pham-Kaplita Derek Yurgaitis Raymond A Firestone

Bioorg Med Chem Lett

July 2003

The 6-maleimidocaproylhydrazone derivatives of highly potent antitumor agents 5-Diacetoxypentyldoxorubicin and Morpholinodoxorubicin were synthesized and conjugated to monoclonal antibody BR96 and control IgG. Immunoconjugate molar ratios were generally 7.5-8.

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Synopsis of recent research by authors named "Kahnie Pham-Kaplita"

  • - Kahnie Pham-Kaplita's research primarily focuses on the synthesis and application of antibody-drug conjugates, specifically involving highly potent anthracycline derivatives for targeted cancer therapy.
  • - In her 2003 study, she synthesized 6-maleimidocaproylhydrazone derivatives of 5-Diacetoxypentyldoxorubicin and Morpholinodoxorubicin, which were conjugated to the monoclonal antibody BR96 and control IgG.
  • - The findings indicated that the immunoconjugates generally maintained a molar ratio of approximately 7.5-8, suggesting a method for improving the efficacy of cancer treatments through targeted delivery systems.

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