Synopsis of recent research by authors named "Kah Tan Allen"
- Kah Tan Allen's research primarily focuses on the mechanisms of metabolic alterations in cancer cells, specifically investigating how dichloroacetate (DCA) can disrupt Warburg metabolism to enhance the effectiveness of radiotherapy in non-small cell lung cancer (NSCLC).
- Additionally, Allen has explored the protective roles of cyclic AMP and soluble adenylyl cyclase in corneal endothelial cells, highlighting how bicarbonate activation can significantly boost cAMP levels, which is crucial for cellular defense mechanisms.
- His work on the epidermal growth factor receptor (EGFR) in breast cancer challenges previous assumptions about its role, emphasizing its significance in the development and metastasis of breast malignancies, indicating a need for re-evaluation of EGFR-targeted therapies.
