Ukr Biokhim Zh (1978)
October 1990
A change in the regulatory activity of glycolysis enzymes in lymphocytes of the peripheral human blood is studied. The phytohemagglutinin-stimulated lymphocytes differ in the intensification of the glycolysis activation on the whole, as well as in the growth of the cell division intensity under the influence of estradiol 17 beta.
View Article and Find Full Text PDFThe effect of substances with radioprotective activity, APAETP 2,3 (aminopropylaminoethylthiophosphoric acid 2,3), APAETP 3,3 and cystaphos, on chromosome aberrations, induced by thioTEPA in the culture of human lymphocytes was investigated. It is shown that the obtained curves "concentration -- effect" for thioTEPA can be described by equations rho = 1 -- e-(KC + alpha)2 and X = E -(KC + alpha)2 --1 for aberrant cells and for chromosome breaks in the presence of the investigated substances. On the basis of comparison of angle coefficients of regression the unificated characteristic of the efficiency of chemical mutagenesis is proposed: the linear protection index (LPI), with generalizes the effect of modificators in chemical mutagenesis.
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