Studies on pediatric patients with absent auditory brainstem response (ABR) later components.

Eleven pediatric patients with only wave I or waves I and II of their ABR were clinically analyzed. The clinical diagnoses of these patients were as follows: 1) anoxic encephalopathy in two cases; 2) neonatal asphyxia in one; 3) infantile Gaucher's disease in one; 4) mitochondrial encephalomyopathy in one; 5) suspected Pelizaeus-Merzbacher disease in three; 6) degenerative disease of unknown etiology in two (presumptive diagnosis were progressive supranuclear palsy and dentate-rubro-pallido-Luysian atrophy); and 7) infantile spasms with congenital malformation of the brain and bones in one. The incidence of the patients with this type of ABR abnormality was 0.

[Clinical diagnoses of pediatric patients without detectable auditory brainstem response (ABR)].

One hundred and forty-seven out of 1,600 infants and children showed no detectable ABR. ABRs were evoked by clicks. As to hearing acuity, 121 out of 147 patients had sensorineural hearing loss and 19 had no hearing impairment of high frequency (3-4 kHz) and high sound intensity (85-90 dBnHL).

[Evaluation of cytotoxicity of VLC Dycal in tissue culture for clinical use].

The purpose of this study was to evaluate the VLC Dycal (visible light cured composite-calcium hydroxide material) to see whether it is suitable or not as a direct or indirect pulp capping agent for clinical use by means of the cell culture test. Two light cured composite resins, P-30 and Silux, and also Dycal and Ca(OH)2 were used as a control for a comparative cytotoxicity test with VLC Dycal. All test materials were put into the glass tubes (4 mm diameter X 1 mm high), then illuminated for 10, 20, 30, 40, 50 and 60 seconds through a matrix strip with direct contact with a Prisma-light source (L.

[Correlation between the illumination time and cytotoxicity of light-cured composite resins].

This study was undertaken to compare the relative cytotoxicity of light cured composite resins, and the cytotoxic reduction of light cured composite resins by illumination time by means of in vitro cell culture test. Light cured composite resins (P-30, Silux, Occlusin, Graft LC, Litefil A, Photo Clearfil A, Palfique light and Herculite XR) were filled into glass tubes (4 mm inner dia. x 1 mm high), then illuminated for 0, 10, 20, 30, 40, 50 and 60 seconds through a matrix strip with direct contact ot an Optilux light source (3M), just before testing.

Cytotoxicity of amalgams.

The purpose of this study was to compare the relative cytotoxicity of amalgams and to determine whether their toxicity depends upon composition and aging time, by means of a rapid and sensitive in vitro cell culture test. Zinc-containing amalgams showed higher cytotoxicity than did any other amalgams. High-copper amalgams had the same cytotoxicity as did the low-copper amalgam.

Problems of trace elements and vitamins during long-term total parenteral nutrition: a case report of idiopathic intestinal pseudo-obstruction.

An 8-year-old girl with chronic idiopathic intestinal pseudo-obstruction (CIIP), who is the first case of CIIP in Japan, has been receiving total parenteral nutrition (TPN) for more than 6 years. During this time, she experienced deficiencies of copper, zinc, vitamin A, vitamin B12, folic acid, and biotin, and an excess of vitamin A; she exhibited a series of signs and symptoms due to these deficiencies and vitamin A overdosage. Nevertheless, careful monitoring of serum levels of trace elements and vitamins and appropriate therapy have almost solved these problems.

[Study on toxicity of halopredone acetate. (I) Acute toxicity study in mice and rats].

Since halopredone acetate (THS-201), a synthetic corticosteroid, is expected to be used clinically for intra-articular injections because of its long-lasting activity in the synovial bursa, its acute toxicity was compared with that of triamsinolone acetonide (TA) and methylprednisolone acetate (MPA). The test animals were Jcl: ICR mice and Jcl: Wistar rats, and drugs were administered orally, intraperitoneally and subcutaneously. The LD50 values of THS-201 both in mice and rats were estimated more than 5000 mg/kg at each route, and these are for above larger than those of TA or MPA.

[Chronic toxicity study of AC-1370 sodium, an antibiotics, intravenously administered in rats].

A study on chronic toxicity of AC-1370 sodium (AC) in addition to recovery from its toxicity, was carried out using the rat. AC was administered to the rat through the tail vein in doses of 30, 100, 300 and 1000 mg/kg body weight/day, with the periods for administration and recovery being 26 and 13 weeks, respectively. The results obtained from the present study were as follows.

Cerebello-brain stem orthochromatic leukodystrophy with floppiness and bulbar paralysis.

A two year and ten-month-old girl with cerebello-brain stem leukodystrophy is presented. She was hypotonic with spasticity and showed delayed motor development until she was twelve months old, when regression of motor activities began. Progressive hypotonia, dysphagia and fatal respiratory abnormalities developed.

Normalization of poor auditory brainstem response in infants and children.

In these past 10 years, the usefulness of auditory brainstem response (ABR) has been demonstrated in the clinical evaluation of audiological or neurological disorders, and the absence of an ABR is commonly accepted as consistent with a peripheral hearing loss caused by middle or inner ear diseases. In this article, the authors report nine infants and children who had an absent or difficult to detect ABR at the first examination with subsequent normalization of ABR. Repeated otological examinations were always normal in these patients.

[Acute toxicity of intrarectally administered (ketoprofen (T10) in rat weanlings].

Acute toxicity of Ketoprofen, a nonsteroidal antiinflammatory analgestic, was studied using rat weanlings. Ketoprofen was intrarectally administered in the form of a mixture with T10, a basic materials for suppositaries. The results obtained were as follows: LD50 of KP was estimated to be 434 mg/kg in male weanlings and 496 mg/kg in female weanlings.

[Carcinogenicity study of cholestyramine in rats].

Carcinogenicity study on cholestyramine, an anti-hypercholesterolemic agent, was carried out using Fischer rats by feeding with a normal pellet diet (control) and with three sorts of the pellet diets in which cholestyramine was admixed in the common diet at the rates of 1.25, 2.5 and 5%, respectively.

A recognizable pattern of the midface of retinoblastoma patients with interstitial deletion of 13q.

In our study, we found a recognizable pattern of the midface in three retinoblastoma patients with interstitial deletion of chromosome 13 in lymphocytes. Further photographs of patients reported by other authors confirmed our conclusion that the midface in children with interstitial deletion of 13q from q12 to q22, always involving q14, is characterized by prominent eyebrows, broad nasal bridge, bulbous tip of the nose, a large mouth with a thin upper lip, and a long philtrum. This midface pattern could not be recognized in patients with normal karyotypes, suggesting that the critical segment for the midface phenotype as well as for retinoblastoma may exist in band 13q14.

[Chronic toxicity study of ranitidine hydrochloride orally administered in rats].

Chronic toxicity of ranitidine hydrochloride, a new histamine H2-receptor antagonist, was studied using Sprague Dawley rats. Ranitidine was administered orally at dose levels of 30, 100, 300 and 1000 mg/kg/day for 26 or 53 weeks. In the 1000 mg/kg/day group, ten of 31 females died showing acute toxic signs.

Auditory brainstem response (ABR) in infantile Gaucher's disease.

The auditory brainstem response (ABR) was studied in an infant with Gaucher's disease. The infant was normal until the age of three months. His illness began with stridor, strabismus, inguinal hernia and failure to thrive.

[Carcinogenicity study of cholestyramine in mice].

Carcinogenicity study of cholestyramine, an anti-hypercholesterolemic agent, was carried out by feeding B6C3F1 mice of both sexes with the pellet diet in which cholestyramine was admixed at the rates of 1.25, 2.5 and 5%.