Tetrylenes Are Able to Discern between Isomeric Structures of Unsaturated Osmium(IV) Polyhydrides.

Hexahydride OsH6(PiPr3)2 (1) releases H2 to form the isomeric tetrahydrides 2a and 2b of general formula OsH4(PiPr3)2. Tetrylenes E{N(SiMe3)2}2 (E = Ge, Sn) are able to selectively trap these isomers distinguishing between them. Tetrylene Ge{N(SiMe3)2}2 catches 2b to generate OsH4{Ge[N(SiMe3)2]2}(PiPr3)2 (3), which has a piano stool geometry, while  Sn{N(SiMe3)2}2 captures 2a to give OsH4{Sn[N(SiMe3)2]2}(PiPr3)2 (4) with the donor atoms defining a pentagonal bipyramid around the osmium center.

Diverse real-life outcomes after intensive risk-adapted therapy for 1034 AML patients from the CETLAM Group.

Given the heterogeneity of acute myeloid leukemia patients, it is necessary to identify patients considered fit for intensive therapy but who will perform poorly, and in whom alternative approaches deserve investigation. We analyzed 1034 fit adults ≤70 years intensively treated between 2012 and 2022 in the CETLAM group. Young adults ( ≤ 60 years) presented higher remission rates and improved survival than older adults above that age (CR 79% vs.

Priming versus propagating: distinct immune effects of an alpha- versus beta-particle emitting radiopharmaceutical when combined with immune checkpoint inhibition.

Radiopharmaceutical therapy (RPT) enhances tumor response to immune checkpoint inhibitors (ICI) in preclinical models, but the effects of different radioisotopes have not been thoroughly compared. To evaluate mechanisms of response to RPT+ICI, we used NM600, an alkylphosphocholine selectively taken up by most tumors. Effects of Y-, Lu-, and Ac-NM600 + ICIs were compared in syngeneic murine models, B78 melanoma (poorly immunogenic) and MC38 colorectal cancer (immunogenic).

High Prevalence of Low Back Pain in College Rifle Athletes.

Background: The sport of rifle places unique physical demands on its athletes relative to other collegiate sports, including maintaining lumbar-straining positions for extended time. Anecdotal reports of low back pain (LBP) are common among collegiate rifle athletes, but the prevalence of LBP in this population has not yet been established in the literature.

Purpose: The purpose of this study was to survey collegiate rifle athletes to quantify the prevalence and impact of low back pain in this population and identify possible contributing factors including the COVID-19 pandemic.

Host-microbe computational proteomic landscape in oral cancer revealed key functional and metabolic pathways between Fusobacterium nucleatum and cancer progression.

Oral squamous cell carcinoma (OSCC) is the most common manifestation of oral cancer. It has been proposed that periodontal pathogens contribute to OSCC progression, mainly by their virulence factors. However, the main periodontal pathogen and its mechanism to modulate OSCC cells remains not fully understood.

The Validity and Usability of Markerless Motion Capture and Inertial Measurement Units for Quantifying Dynamic Movements.

Purpose: Motion capture technology is quickly evolving providing researchers, clinicians, and coaches with more access to biomechanics data. Markerless motion capture and inertial measurement units (IMUs) are continually developing biomechanics tools that need validation for dynamic movements before widespread use in applied settings. This study evaluated the validity of a markerless motion capture, IMU, and red, green, blue, and depth (RGBD) camera system as compared to marker-based motion capture during countermovement jumps, overhead squats, lunges, and runs with cuts.

Immunoinformatic design of a multivalent vaccine against and its evaluation in a murine model using a DNA prime-protein boost strategy.

Introduction: The development of effective vaccines against is critical due to its significant impact on human and animal health. The objective of this study was to design and evaluate and a multivalent vaccine based on the immunogenic potential of three selected open reading frames (ORFs) of .

Methods: The designed construct, named S22, was analyzed to evaluate its physicochemical properties, antigenicity, allergenicity and toxicity.

Improved energy equations and thermal functions for diatomic molecules: a generalized fractional derivative approach.

Context: This work presents analytical expressions for ro-vibrational energy models of diatomic molecules by introducing fractional parameters to improve molecular interaction analysis. Thermodynamic models, including Helmholtz free energy, mean thermal energy, entropy, and isochoric heat capacity, are formulated for diatomic molecules such as CO (X ∑), Cs (3 ∑), K (X ∑), Li (6 Π), Li (1 Δ), Na (5 Δ), Na (C(2) Π), and NaK (c ∑). The incorporation of fractional parameters improves predictive accuracy for vibrational energies, as shown by reductions in percentage average absolute deviations from 0.

Miniaturized Shear Testing: In-Plane and Through-Thickness Characterization of Plywood.

This study addresses the challenges associated with conventional plywood shear testing by introducing a novel miniaturized shear test method. This approach utilizes a controlled router toolpath for precise sample fabrication, enabling efficient material use and data acquisition. Miniaturized samples, designed with double shear zones, were tested for τ, τ, and τ configurations using a universal testing machine.

High-Performance Concrete from Rubber and Shell Waste Materials: Experimental and Computational Analysis.

Waste and its environmental impact have driven the search for sustainable solutions across various industries, including construction. This study explores the incorporation of solid waste in the production of eco-friendly structural concrete, aiming to reduce pollution and promote ecological and sustainable construction practices. In this context, two types of eco-friendly concrete were produced using marine shells and recycled rubber as waste materials and compared with conventional concrete through experimental and computational approaches.

Relativistic bound state solutions and quantum information theory in D dimensions under exponential-type plus Yukawa potentials.

The bound-state solution of the radial Klein-Gordon equation has been obtained under the interaction of an exponential-type and Yukawa potential functions. The Greene-Aldrich approximation has been used to overcome the centrifugal barrier and enable the analytical solutions of the energy and wave functions in closed form. The momentum space wave function in D dimensions has been constructed using the Fourier transform.

Examining the quantum fisher information in the interaction of a dirac system with a squeezed generalized amplitude damping channel.

The inherent association between real quantum systems and their surrounding environment invariably results in decoherence, leading to the loss of entanglement. This diminution in entanglement coincides with a decline in the fidelity of transmitted information using the entangled quantum resource. This study scrutinizes the impact of the squeezed generalized amplitude damping (SGAD) channel on quantum Fisher information (QFI) parameters.

Genome Editing Therapy for the Blood: Success and Prospects.

Hematopoietic stem cells (HSCs) provide the body with a continuous supply of healthy, functional blood cells. In patients with hematopoietic malignancies, immunodeficiencies, lysosomal storage disorders, and hemoglobinopathies, therapeutic genome editing offers hope for corrective intervention, with even modest editing efficiencies likely to provide clinical benefit. Engineered white blood cells, such as T cells, can be applied therapeutically to address monogenic disorders of the immune system, HIV infection, or cancer.

Recommendations for clinical decision-making when offering exoskeletons for community use in individuals with spinal cord injury.

Approved in 2014 by the Food and Drug Administration (FDA) for use with a trained companion, personal powered exoskeletons (PPE) for individuals with spinal cord injury (SCI) provide an opportunity for the appropriate candidate to ambulate in their home and community. As an adjunct to wheeled mobility, PPE use allows those individuals who desire to ambulate the opportunity to experience the potential physiological and psychosocial benefits of assisted walking outside of a rehabilitation setting. There exists, however, a knowledge gap for clinicians regarding appropriate candidate selection for use, as well as who might benefit from ambulating with a PPE.

Efficient Mako Shark-Inspired Aerodynamic Design for Concept Car Bodies in Underground Road Tunnel Conditions.

The automotive industry continuously enhances vehicle design to meet the growing demand for more efficient vehicles. Computational design and numerical simulation are essential tools for developing concept cars with lower carbon emissions and reduced costs. Underground roads are proposed as an attractive alternative for reducing surface congestion, improving traffic flow, reducing travel times and minimizing noise pollution in urban areas, creating a quieter and more livable environment for residents.

Severity and organ distribution of graft-versus-host disease with post-transplant cyclophosphamide versus calcineurin inhibitor plus methotrexate/mycophenolate mofetil or sirolimus in allogenic HLA-matched or single-allele mismatched stem cell transplantation.

Objective: This retrospective single center study aims to describe changes in the severity and organ-specific distribution of GvHD, by comparing the outcomes of 3 distinct GvHD prophylaxis approaches.

Methods: Between January 2012 and June 2022, 226 patients underwent allogeneic hematopoietic stem cell transplantation from HLA-matched or 1-allele mismatched related or unrelated donors. Fifty-eight (26%) received prophylaxis with calcineurin inhibitor in combination with mycophenolate mofetil or a short course of methotrexate (Cohort-1), 87 (38%) tacrolimus plus sirolimus (Cohort-2), and 81 (36%) post-transplant cyclophosphamide (PTCy) plus tacrolimus (Cohort-3).

Major depletion of insulin sensitivity-associated taxa in the gut microbiome of persons living with HIV controlled by antiretroviral drugs.

Background: Persons living with HIV (PWH) harbor an altered gut microbiome (higher abundance of Prevotella and lower abundance of Bacillota and Ruminococcus lineages) compared to non-infected individuals. Some of these alterations are linked to sexual preference and others to the HIV infection. The relationship between these lineages and metabolic alterations, often present in aging PWH, has been poorly investigated.

Stromal KITL/SCF promotes pancreas tissue homeostasis and restrains tumor progression.

Components of normal tissue architecture serve as barriers to tumor progression. Inflammatory and wound-healing programs are requisite features of solid tumorigenesis, wherein alterations to immune and non-immune stromal elements enable loss of homeostasis during tumor evolution. The precise mechanisms by which normal stromal cell states limit tissue plasticity and tumorigenesis, and which are lost during tumor progression, remain largely unknown.

Silent Struggles: Traumatic Brain Injuries and Mental Health in Law Enforcement.

Objective: To determine the prevalence of head injuries (HIs), posttraumatic stress disorder (PTSD), and depressive symptoms in law enforcement officers (LEOs) and (2) the association between HIs and psychological health conditions.

Setting: County-level survey administered via Research Electronic Data Capture.

Participants: A total of 381 LEOs completed the survey (age = 43 ± 11 years; 40 [11%] females; time as LEO = 1-50 years, median = 15 years).

A Lead-μ-Tetrylide Complex with Osmium(IV) Terminal Components.

A bare lead atom is a σ-donor ligand capable of linearly bonding and stabilizing two units of a classical polyhydride complex, with a high-valent metal center. As a proof of concept, we have prepared and characterized the μ-tetrylide complex (PPr)HOs═Pb═OsH(PPr) in the reaction of OsH(PPr) with Pb{N(SiMe)}. Although the Pb-Os bonds exhibit electrostatic interaction, the main orbital interactions result from two dative σ bonds from the lead atom to the osmium centers.

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) in primary human immune cells and hematopoietic stem cells.

Peptide-enabled ribonucleoprotein delivery for CRISPR engineering (PERC) is a new approach for ex vivo genome editing of primary human cells. PERC uses a single amphiphilic peptide reagent to mediate intracellular delivery of the same pre-formed CRISPR ribonucleoprotein enzymes that are broadly used in research and therapeutics, resulting in high-efficiency editing of stimulated immune cells and cultured hematopoietic stem and progenitor cells (HSPCs). PERC facilitates nuclease-mediated gene knockout, precise transgene knock-in, and base editing.

Evaluation of the Humoral Response after Immunization with a Chimeric Subunit Vaccine against Shiga Toxin-Producing in Pregnant Sows and Their Offspring.

Shiga toxin-producing (STEC) poses a significant public health risk due to its zoonotic potential and association with severe human diseases, such as hemorrhagic colitis and hemolytic uremic syndrome. Ruminants are recognized as primary reservoirs for STEC, but swine also contribute to the epidemiology of this pathogen, highlighting the need for effective prevention strategies across species. Notably, a subgroup of STEC that produces Shiga toxin type 2e (Stx2e) causes edema disease (ED) in newborn piglets, economically affecting pig production.

Global compositional and functional states of the human gut microbiome in health and disease.

The human gut microbiota is of increasing interest, with metagenomics a key tool for analyzing bacterial diversity and functionality in health and disease. Despite increasing efforts to expand microbial gene catalogs and an increasing number of metagenome-assembled genomes, there have been few pan-metagenomic association studies and in-depth functional analyses across different geographies and diseases. Here, we explored 6014 human gut metagenome samples across 19 countries and 23 diseases by performing compositional, functional cluster, and integrative analyses.