Publications by authors named "Kaeli N Bryant"
Article Synopsis
- The study focuses on the structural and proteomic analysis of Cag T4SSs derived from deletion mutants.
- It emphasizes the surprising structural independence between two key subdomains: the outer membrane complex (OMC) and the pilot region (PR).
- This finding challenges previous assumptions about the interdependence of these components within the T4SS structure.
Article Synopsis
- * The OMCC consists of a 14-fold symmetric outer membrane cap (OMC), a 17-fold symmetric periplasmic ring (PR), and an undefined stalk, with specific proteins (CagY, CagX, CagM, CagT) involved in organization.
- * Cryo-electron microscopy revealed that while the PR maintains structure without some proteins, the OMC’s organization requires multiple proteins, indicating a structural independence between the OMC and PR within the Cag T4SS
Article Synopsis
- Strains of bacteria can be categorized into two groups based on the presence of a pathogenicity island (PAI), which influences their impact on human health.
- Colonization of the stomach by PAI-positive strains is linked to a higher risk of gastric cancer and peptic ulcers compared to PAI-negative strains.
- The PAI encodes a protein called CagA and a secretion system that helps deliver CagA into host cells, which triggers inflammation and contributes to gastric diseases.
colonization of the human stomach is a strong risk factor for gastric cancer. To investigate -induced gastric molecular alterations, we used a Mongolian gerbil model of gastric carcinogenesis. Histologic evaluation revealed varying levels of atrophic gastritis (a premalignant condition characterized by parietal and chief cell loss) in -infected animals, and transcriptional profiling revealed a loss of markers for these cell types.
View Article and Find Full Text PDFThe localization of lipoprotein (Lol) system is used by Gram-negative bacteria to export lipoproteins to the outer membrane. Lol proteins and models of how Lol transfers lipoproteins from the inner to the outer membrane have been extensively characterized in the model organism Escherichia coli, but in numerous bacterial species, lipoprotein synthesis and export pathways deviate from the E. coli paradigm.
View Article and Find Full Text PDFis an intracellular alphaproteobacterium that infects 40%-60% of insect species and is well known for host reproductive manipulations. Although are primarily maternally transmitted, evidence of horizontal transmission can be found in incongruent host-symbiont phylogenies and recent acquisitions of the same strain by distantly related species. Parasitoids and predator-prey interactions may indeed facilitate the transfer of between insect lineages, but it is likely that are acquired via introgression in many cases.
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