Identification of novel MYH14 variants in families with autosomal dominant sensorineural hearing loss.

Autosomal dominant sensorineural hearing loss (ADSNHL) is a genetically heterogeneous disorder caused by pathogenic variants in various genes, including MYH14. However, the interpretation of pathogenicity for MYH14 variants remains a challenge due to incomplete penetrance and the lack of functional studies and large families. In this study, we performed exome sequencing in six unrelated families with ADSNHL and identified five MYH14 variants, including three novel variants.

Vestibular functions in patients with tinnitus only.

Objective: Tinnitus is the perception of sound in the ears or head without any external or internal acoustic stimulation, and it is usually associated with hearing loss. In addition, it has been reported that there is a relationship between vestibular problems and sensorineural hearing loss. The aim of this study was to evaluate the vestibular function in patients with tinnitus without hearing loss.

Evaluation of vestibular system with vHIT in industrial workers with noise-induced hearing loss.

Purpose: Industrial workers are frequently exposed to noise and the noise can cause hearing loss. The relationship between vestibular abnormalities and long-term exposure to occupational noise has been reported. The aim of this study was to use vHIT (video head impulse test) to evaluate the semicircular canal's function in industrial workers with noise-induced hearing loss.

Evaluation of superior concha bullosa by computed tomography.

Objective: Concha bullosa is generally regarded as pneumatisation of the middle turbinate in the nose. However, pneumatisation may also be seen in the superior and inferior turbinate. Computed tomography (CT) of paranasal sinuses is extremely helpful for the examination of this inaccessible area.

l-N-acetylcysteine protects outer hair cells against TNFα initiated ototoxicity in vitro.

Objective: The present study is aimed at determining the efficacy and exploring the mechanisms by which l-N-acetylcysteine (l-NAC) provides protection against tumor necrosis factor-alpha (TNFα)-induced oxidative stress damage and hair cell loss in 3-day-old rat organ of Corti (OC) explants. Previous work has demonstrated a high level of oxidative stress in TNFα-challenged OC explants. TNFα can potentially play a significant role in hair cell loss following an insult to the inner ear.

Advanced Otosclerosis: Stapes Surgery or Cochlear Implantation?

Diagnosis and treatment of advanced otosclerosis can be controversial. In 1961, House and Sheehy defined advanced otosclerosis as hearing loss in air conduction threshold by 85 dB with nonmeasurable bone conduction. Recently, the definition of advanced otosclerosis is mostly based on the decrease of speech recognition.

Clinical, surgical, and electrical factors impacting residual hearing in cochlear implant surgery.

Conclusions: This study recommends using soft surgical principal and round window insertion to protect residual hearing with favorable anatomical exposure. Further studies are needed to evaluate the impact of the electrical stimulation on the organ of corti and hearing.

Objective: The objective of this study is to analyze various factors that impact on preservation of residual hearing post-implantation.

Aphthous Ulcer of the Vocal Cord Leading to Hoarseness.

Acute or chronic laryngitis, laryngeal trauma, vocal cord paralysis, cysts of the vocal cord, and benign or malignant tumors of the vocal folds are frequent causes of hoarseness. It is important to identify the cause of hoarseness to rule out potential malignancies. In this case report, we describe a patient with a bilateral aphthous ulcer in the vocal cords who was admitted with hoarseness and had been previously diagnosed with Behcet disease.

Retrospective analysis of surgical treatment of choanal polyps.

Objectives: This study aims to discuss the efficacy of the surgical method performed in patients with choanal polyp in the light of the literature.

Patients And Methods: The study included 76 patients (42 males, 34 females; mean age 25.36 years; range 7 to 73 years) diagnosed with choanal polyp in the sinonasal region between January 2005 and December 2013 in the otorhinolaryngology clinic of Kocaeli University.

[Bilateral inverted papilloma originating from the frontal sinus].

Inverted papilloma is a benign neoplasm characterized by its high rate of recurrence, local aggressiveness, and malignancy potential. Nasal obstruction is the most frequent presenting complaint. Bilateral inverted papillom involving both sides of the frontal sinus is extremely rare.

Bilateral sudden sensorineural hearing loss caused by leptomeningeal carcinomatosis: case report and review.

Leptomeningeal carcinomatosis is a rare condition characterized by diffuse infiltration of the meninges after the metastasis of the solid tumors. Bilateral sudden hearing loss is a rare initial symptom. In this article, we report a 44-year-old male patient with bilateral sudden hearing loss and dizziness.

[Sinonasal teratocarcinosarcoma].

Sinonasal teratocarcinosarcoma is an extremely rare malignant neoplasm presenting with the characteristics of a malignant teratoma and carcinosarcoma. The most common sites of origin of teratocarcinosarcomas are the nasal cavity and paranasal sinuses. The clinical presentation is usually with nasal obstruction and episodes of epistaxis.

The effect of alprazolam on acoustic stapedius reflex thresholds in healthy volunteers.

Alprazolam, a widely used drug, has widespread, nonspecific depressant effects on the central nervous system, similar to other benzodiazepines. This inhibitor effect may cause changes in reflex thresholds by affecting the acoustic stapedial reflex (ASR) arc. This study was performed on 31 healthy volunteers.

The effect of memantine on functional recovery of the facial nerve after crush injury.

The objective of this study is to establish whether memantine is an alternative and effective treatment on facial nerve recovery after crush injury, and also to analyze the effective doses of this promising agent. This is a randomized controlled animal study. 40 rats underwent crush injury to left main trunk of the facial nerve, and divided into 4 groups; (1) control (saline treated), (2) 5-mg/kg memantine, (3) 10-mg/kg memantine, and (4) 20-mg/kg memantine group.

Meningioma arising from the anterior skull base and filling the nasal cavity.

Meningiomas are usually benign tumors that are frequently encountered in the intracranial region. They account for 15% of the overall intracranial tumors. Of the intracranial meningiomas, less than 3% extend up to the sinonasal region.

[Juvenile angiofibroma originating from the sphenoid sinus: a case report].

Angiofibromas are histologically benign, but unencapsulated and highly vascular tumors with a potential of local destructive effect. Angiofibromas predominantly originate from the posterolateral wall of the nasopharynx. Extranasopharyngeal angiofibromas are extremely rare and mostly seen in maxillary sinus and ethmoid sinus.

[Endoscopic management of cerebrospinal fluid fistulas and clinic outcomes].

Objectives: This study aims to evaluate the efficacy of endoscopic repair of cerebrospinal fluid (CSF) fistulas.

Patients And Methods: Between January 2005 and December 2012, 10 patients (7 females, 3 males; mean age 36.1 years; range 1 to 52 years) who were diagnosed with CSF fistulas in Kocaeli University, Faculty of Medicine, Ear Nose and Throat Clinic were retrospectively analyzed.

Fibrolipoma of the nasal septum; report of the first case.

Background/objective: Fibrolipomas are a rare subtype of lipomas and very rare in the oral and maxillofacial region. Lipomas affecting the central nervous system are even more infrequent occurring with a frequency of 0.1%.