Recurrent Hospitalisation in a Child With Hypopigmented Hair: Inborn Errors of Immunity Emerge.

Griscelli syndrome is a rare autosomal recessive disorder characterised by pigmentary dilution of skin and hair, recurrent skin and pulmonary infections, neurological manifestations, and immunodeficiency. We present a four-month-old female child with hypopigmented silvery hair and a history of recurrent hospitalisations for respiratory illness. The child was extensively evaluated for inborn errors of immunity (IEI), and the final diagnosis of type 2 Griscelli syndrome was made only after genetic testing.

Oxidation Behavior of Nanocrystalline Alloys.

Thermo-mechanically stabilized nanocrystalline (NC) alloys are increasingly valued for their enhanced mechanical strength and high-temperature stability, achieved through thermodynamic and kinetic stabilization methods. However, their fine-grained structure also increases susceptibility to internal oxidation due to higher atomic diffusivity associated with a greater volume fraction of grain boundaries (GBs). By incorporating solutes that form protective oxides, or the so-called thermally growing oxides (TGO), this vulnerability can be mitigated.

Pathologic features of head and neck adult rhabdomyosarcoma: Case series.

Introduction: Adult Head and neck Rhabdomyosarcomas (HNRMS) are exceedingly rare and remain challenging for pathologists.

Cases Presentation: Five cases of adult HNRMS (≥19 years) were retrieved from the archives of the Department of Pathology of Hospital of Specialities in Rabat (HSR) in Morocco, over 5 years. Clinical and pathologic findings from hematoxylin and eosin slides and immunohistochemistry for Desmin and Myogenin were reviewed.

Chondroblastic osteosarcoma of the nasal cavity: an exceptional and misdiagnosed presentation.

Chondroblastic osteosarcoma of the nasal cavity is a rare and aggressive tumor that presents diagnostic challenges due to its variable clinical and radiological features. Histological analysis is crucial for an accurate diagnosis, despite morphological similarities with chondrosarcoma. We present a case of primary craniofacial chondroblastic osteosarcoma originating from the nasal cavity in a 17-year-old adolescent.

Exploring a rare case of juvenile psammomatoid ossifying fibroma in the ethmoid: a case study and review.

Juvenile ossifying fibroma (JOF) and its variants, including juvenile psammomatoid ossifying fibroma (JPOF), represent rare yet clinically significant benign fibro-osseous lesions that primarily occur in children and young adolescents. They can be found in diverse anatomical sites such as the jaw, nasal cavity, paranasal sinuses, and orbit. JOF exhibits an aggressive nature, necessitating early radiological detection and surgical intervention.

Prenatal double-hit with aluminium and cadmium mediate testicular atrophy and hypothalamic hypoplasia: the role of oxido-nitrergic stress and endocrine perturbations.

There is limited experimental evidence on the biochemical consequences of aluminium (Al) and cadmium (Cd) co-exposures during pregnancy and postnatal life.This study investigated the impacts of perinatal Al chloride (AlCl) and Cd chloride (CdCl) co-exposures on neuroendocrine functions in mice offspring during postnatal life. The study comprised of four pregnant experimental groups.

Multiplexed Gas Sensor: Fabrication Strategies, Recent Progress, and Challenges.

Due to miscellaneous toxic gases in the vicinity, there is a burgeoning need for advancement in the existing gas sensing technology not only for the survival of mankind but also for the industries based in various fields such as beverage, forestry, health care, environmental monitoring, agriculture, and military security. A gas sensor must be highly selective toward a specific gas in order to avoid incorrect signals while responding to nontarget gases. This may lead to complex scenarios depicting sensor defects, such as low selectivity and cross-sensitivity.

A review of cost-effective black silicon fabrication techniques and applications.

Ever since the discovery of black silicon, scientists around the world have been trying to come up with novel, cost-effective methods of utilizing this super material in a variety of different industries due to its remarkably low reflectivity and excellent electronic and optoelectronic properties. In this review, many of the most common methods of black silicon fabrication are exhibited, including metal-assisted chemical etching, reactive ion etching, and femto-second laser irradiation. Different nanostructured silicon surfaces are assessed based on their reflectivity and applicable properties in both the visible wavelength range and the infrared range.

Assessment of deep learning algorithms to predict histopathological diagnosis of breast cancer: first Moroccan prospective study on a private dataset.

Objective: Breast cancer is a critical public health issue and a leading cause of cancer-related deaths among women worldwide. Its early diagnosis and detection can effectively help in increasing the chances of survival rate. For this reason, the diagnosis and classification of breast cancer using Deep learning algorithms have attracted a lot of attention.

The effect of temporary closure and enhanced terminal disinfection using aerosolized hydrogen peroxide of an open-bay intensive care unit on the acquisition of extensively drug-resistant Acinetobacter baumannii.

Background: At Makassed Hospital's open-bay intensive care unit (ICU), enhanced terminal disinfection (ETD) using hydrogen peroxide (HO) was performed without a predefined schedule in extensively-drug-resistant Acinetobacter baumannii (XDR-AB) outbreaks. In this study, we aimed to check for the value of the temporary closure of the ICU and the use of ETD with aerosolized HO and Ag on minimizing the rate of XDR-AB acquisition in patients admitted to the ICU of our facility, which might consequently help us determine the optimal schedule for such procedure in this unit.

Methods: This is a retrospective medical file review of patients admitted to the ICU between January 2016 and May 2018.

Crystal Plasticity Modeling of Anisotropic Hardening and Texture Due to Dislocation Transmutation in Twinning.

In crystalline materials, dislocations are three-dimensional lattice distortions that systematically distort twin interfaces that they encounter. This results in dislocation dissociation events and changes in the atomic structure of the interface. The manner in which the interface distorts drive the product of the dissociation event, and consequently, the incident dislocation core and the magnitude and relative direction of the Burgers vector govern these slip-twin interaction phenomena.

Invasive Lobular Carcinoma of the Breast with Extracellular Mucin: Case Report of a New Variant of Lobular Carcinoma of the Breast.

Invasive carcinoma of no special type (NST) or ductal carcinoma is the largest group of invasive breast cancers. Invasive lobular carcinoma (ILC) is the second most common histological type; it comprises 5%-15% of all invasive breast cancers. Historically, lobular neoplasia and invasive lobular carcinoma may produce intracellular mucin that pushes the nucleus to one side, creating the characteristic signet ring cell morphology.

Modeling the Effect of Primary and Secondary Twinning on Texture Evolution during Severe Plastic Deformation of a Twinning-Induced Plasticity Steel.

Modeling the effect of deformation twinning and the ensuing twin-twin- and slip-twin-induced hardening is a long-standing problem in computational mechanical metallurgy of materials that deform by both slip and twinning. In this work, we address this effect using the twin volume transfer method, which obviates the need of any cumbersome criterion for twin variant selection. Additionally, this method is capable of capturing, at the same time, secondary or double twinning, which is particularly important for modeling in large strain regimes.

T300A variant of AT16L1 gene in a cohort of Algerian Crohn disease patients.

The T300A variant is among the most Crohn's disease (CD) associated genetic variants. The aim of our study is to bring a first insight about the contribution of the T300A variant in a cohort of Algerian CD. In a case/control design, 118 Algerian CD patients and 161 unrelated healthy subjects were genotyped for the T300A variant using the allelic discrimination test by Applied Biosystems Taqman genotyping technology.

Influence of farmyard manure on some morphological and biochemical parameters of cowpea (Vigna unguiculata) seedling grown in cadmium-treated soil.

The present study aims to assess the effects of the two kinds of farmyard manure (poultry and pig manures) as amendments for soil on cadmium (Cd) toxicity in plants using cowpea seedlings as plant model. Cd toxicity was evaluated by assessing the effect of the metal on the growth rate and antioxidant status as well as the ability of the plant to metabolise xenobiotic. There was a significantly (p < 0.

Acoustic Emission of Deformation Twinning in Magnesium.

The Acoustic Emission of deformation twinning in Magnesium is investigated in this article. Single crystal testing with combined full field deformation measurements, as well as polycrystalline testing inside the scanning electron microscope with simultaneous monitoring of texture evolution and twin nucleation were compared to testing at the laboratory scale with respect to recordings of Acoustic Emission activity. Single crystal testing revealed the formation of layered twin boundaries in areas of strain localization which was accompanied by distinct changes in the acoustic data.

Topology assisted self-organization of colloidal nanoparticles: application to 2D large-scale nanomastering.

Our aim was to elaborate a novel method for fully controllable large-scale nanopatterning. We investigated the influence of the surface topology, i.e.

Is there any advantage to combined trastuzumab and chemotherapy in perioperative setting her 2neu positive localized gastric adenocarcinoma?

We report here a 44-year-old Moroccan man with resectable gastric adenocarcinoma with overexpression of human epidermal growth factor receptor 2 (HER2) by immunohistochemistry who was treated with trastuzumab in combination with chemotherapy in perioperative setting. He received 3 cycles of neoadjuvant chemotherapy consisting of trastuzumab, oxaliplatin, and capecitabine. Afterwards, he received total gastrectomy with extended D2 lymphadenectomy without spleno-pancreatectomy.

Diagnostic challenge for ovarian malignant melanoma in premenopausal women: primary or metastatic?

Background: In the ovary, metastatic malignant melanoma may be confused with primary malignant melanoma and presents a diagnosis challenge. Most cases are associated with disseminated diseases and poor prognosis. We present this case report of a metastatic ovarian malignant melanoma simulating primary ovarian cancer.

Breast cancer treatment and sexual dysfunction: Moroccan women's perception.

Background: This exploratory prospective study evaluated women's responses to questions that asked them to describe how their body image and sexual functioning had changed since their breast cancer diagnosis to treatment.

Methods: A questionnaire concerning body image scale and various sexual problems experienced after diagnosis and treatment was anonymously completed by 120 women in the outpatient clinic of our hospital's Division of medical Oncology. To be eligible, subjects had to be sexually active and had histology proven breast cancer.

The effects of water and microstructure on the mechanical properties of bighorn sheep (Ovis canadensis) horn keratin.

The function of the bighorn sheep horn prompted quantification of the various parametric effects important to the microstructure and mechanical property relationships of this horn. These parameters included analysis of the stress-state dependence with the horn keratin tested under tension and compression, the anisotropy of the material structure and mechanical behavior, the spatial location along the horn, and the wet-dry horn behavior. The mechanical properties of interest were the elastic moduli, yield strength, ultimate strength, failure strain and hardness.

Management of stage one and two-E gastric large B-cell lymphoma: chemotherapy alone or surgery followed by chemotherapy?

Unlabelled: Management of localized primary gastric B lymphoma (PGL) remains controversial. The aim of this study is to compare two treatments: chemotherapy alone and surgery plus chemotherapy.

Materials: Records of all patients with a diagnosis of gastric lymphoma and which were treated in the National Institute of Oncology, between 1999 and 2006, were reviewed and patients fulfilling the following criteria were included in this study: histologically proven large-cell B lymphoma of the stomach; complete clinical information stage I/II disease according to the Musshoff staging; patients who received surgery followed by chemotherapy (group I) or chemotherapy alone (group II).