Publications by authors named "Kadir Isidan"
Corydalis is an herbal plant found in Asian countries. Research has demonstrated multiple health benefits. It has also been implicated in drug-induced liver injury.
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- Liver fibrosis is caused by the activation of hepatic stellate cells (HSCs), which transforms them into myofibroblasts, but the mechanisms underlying this process are not well understood.
- Researchers conducted a single-cell transcriptomic analysis on HSCs from mice treated with carbon tetrachloride, identifying eight distinct HSC subpopulations, each with unique gene expression profiles.
- One notable HSC cluster was linked to liver regeneration and immune response, revealing important genes, while insights gained from the mouse model showed similarities to the heterogeneity found in human cirrhotic livers.