Publications by authors named "Kadir Coban"
Background: In this study, the efficacy of an IL-6 antagonist, Tocilizumab, administered in the early period was studied in intensive care patients with COVID-19 pneumonia followed by hypoxic and systemic inflammation not receiving mechanical ventilation support.
Methods: Patients with COVID-19 pneumonia who have signs of hypoxia and systemic inflammation and/or who have acute bilateral infiltrates on chest radiograph and who received tocilizumab treatment were compared with the patients who received standard medical therapy. Patients who were followed up with COVID-19 pneumonia and respiratory failure between March 2020 and March 2021 were retrospectively evaluated in the study.
Article Synopsis
- This study analyzed the characteristics and outcomes of severe COVID-19 cases in a Turkey-based intensive care unit over one year, focusing on clinical and laboratory data of 213 patients.
- Patients were primarily older adults with a median age of 66, with 77.9% having at least one comorbidity; treatments included invasive mechanical ventilation, tocilizumab, and pulse steroids, and 44.6% of patients ultimately died.
- The findings suggest that COVID-19 symptoms can escalate quickly, with a median of four days from the first symptom to hospital admission and nine days to needing intubation, highlighting the need for greater data sharing to understand the disease's progression better.