Publications by authors named "Kadidiatou Tamboura"
Article Synopsis
- The study aimed to evaluate how genetic variations (polymorphisms) in CYP2B6 and CYP3A4 affect the health responses of HIV-positive patients, focusing on their viral load and immune system functioning.
- A total of 153 patients were involved, and assessments were made on their viral loads and CD4 T cell counts at the start and after six months, utilizing TaqMan genotyping assays to identify genetic markers.
- Results indicated that certain genetic variations, particularly in CYP2B6, correlate with viral load suppression and increases in CD4 cell counts, suggesting these genetic markers could help predict treatment outcomes in HIV patients.
Cytochrome P450 enzymes play a central role in the phase I biotransformation process of a wide range of compounds, including xenobiotics, drugs, hormones and vitamins. It is noteworthy that these enzymes are highly polymorphic and, depending on the genetic makeup, an individual may have impaired enzymatic activity. Therefore, the identification of genetic variants in these genes could facilitate the implementation of pharmacogenetic studies and genetic predisposition to multifactorial diseases.
View Article and Find Full Text PDFGlutathione S-transferase genes, known to be highly polymorphic, are implicated in the process of phase II metabolism of many substrates, including xenobiotics, anticancer and anti-infective drugs. The detoxification activity is linked to individual genetic makeup. Therefore, the identification of alleles and genotypes in these genes within a population may help to better design genetic susceptibility and pharmacogenetic studies.
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