The collaborative character of the immune response requires direct cell- to cell or humoral contacts between the lymphocytes and the cells of mononuclear phagocyte system. The proposed model of direct interrelationship between the cells of the CNS and the immune system throws much light on the morphology of the lymphocyte entry and its recruitment into parenchyma during pathology. The structure, distribution and membrane morphology of the formed in situ rosette-like clusters (containing microglia, as CNS type of mononuclear phagocytes, and syngeneic lymphocytes) was investigated by light and scanning electron microscopy (SEM).
View Article and Find Full Text PDFWe have studied the sequence of expression in the oligodendrocyte of four myelin constituents: galactosylceramide (GalC), myelin basic protein (MBP), proteolipid protein (PLP) and Wolfgram protein (W1). These investigations were performed on freshly dissociated cell preparations from mouse olfactory bulb and cerebellum before and during early myelinogenesis. Our data showed that the first myelin antigen to be detected in the oligodendrocyte was GalC, followed 24 h later by W1 and after a 5-day time lag (relative to GalC) by MBP.
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