Ciprofloxacin-encapsulated solid lipid nanoparticles: a comprehensive biochemical analysis of cytotoxic effects, proliferation inhibition, and apoptotic induction in KG1-a leukemia cells.

As a fundamental approach to the treatment of acute myeloid leukemia (AML), chemotherapeutic agents face significant clinical challenges, including poor solubility and low bioavailability. In this context, solid lipid nanoparticles (SLNs) have emerged as a promising drug delivery system in oncologic therapies, owing to their advantageous characteristics, such as enhanced physical stability and controlled drug-release profiles. This study focuses on the synthesis of ciprofloxacin (CP)-loaded SLNs, aiming to enhance the anticancer efficacy of CP, an antibiotic recognized for its potential anticancer properties, while simultaneously reducing its associated side effects.

Effect of Some Immunological Markers on The Level of Anti- Mullerian Hormone (AMH) in Women Infected with Toxoplasma gondii.

Objective: Aim: To study effect of T. gondii infection on levels of immunological parameters for possible effects that may appear in infected women in the future, and to study direct correlation of infection in raising AMH value.

Patients And Methods: Materials and Methods: 80 blood samples were collected and divided into two equal groups.

Genetic polymorphism of the CYP11B2 gene in an Iraqi patient with essential hypertension.

Objective: Aim: To demonstrate the genetic variant of CYP11B2 Gen rs1799998 and rs4539 and their ef f ect on systolic and diastolic blood pressure in Iraqi patient with essential hypertension in Aldiwania province.

Patients And Methods: Materials and Methods: This is an observational cross sectional descriptive single centre study for hypertensive patients at Al-Diwaniyah province, Iraq which is diagnosed according to 2020 ISH. All candidate patients were diagnosed and recruited by specialist caregiving physician/ cardiologist.

Association between plasma angiotensinogen level and response to valsartan among sample of Iraqi hypertensive patients.

Objective: Aim: The main aim of the present paper is to investigate allele frequencies of rs1799983 polymorphism eNOS genes and to determine association between rs1799983 polymorphism of eNOS gene and essential hypertension in Iraqi hypertensive patients.

Patients And Methods: Materials and Methods: Data obtained at the Al-Diwaniyah teaching hospital in Iraq by researchers from the Department of Pharmacology and Therapeutics in the College of Medicine at University of Al-Qadisiyah from July 2022 to July 2023. All participants (aged 20 to 70) had been taking valsartan 160 mg once day for essential hypertension for at least two weeks before to the study.

Measurement of radioactivity and hazard index of Gonadal dose in selected Cement samples in Iraq.

Given the importance of cement as a basic material in construction, this study was undertaken to evaluate the level of radioactivity in a selected group of cement samples most used in construction to determine whether they are safe for human health. In this investigative study, nine samples of cement, both domestic and imported, that are often used in construction projects in Iraq were gathered. A NaI (Tl) gamma-ray spectrometer (3"x3") was used to measure the radioactivity in the samples.

Calculation of radiological risks for selected soil samples from the north of Kufa district in Najaf, Iraq.

Objective: To evaluate radioactivity levels in soil samples and their physical impact on the population.

Methods: The experimental radiation study was conducted in northern Kufa, Al Najaf Governorate, Iraq, in March 2020 by researchers from the Kufa University, Iraq and comprised soil samples. A gamma spectrometer equipped with a sodium iodide detector activated with a trace amount of thallium was used to calculate the concentration of radium, thorium and potassium.

Distribution of radionuclides in the soils and assessment of radiation hazards in AL Najaf, Iraq: A cross sectional analysis.

Objective: To evaluate radioactivity levels in soil samples and their physical impact on the population.

Methods: The experimental radiation study was conducted by researchers belonging to the Kufa University in Al- Najaf, Iraq, in August 2020, and comprised soil samples from Al-Rahma area. Sodium iodide detector activated with a trace amount of Thallium with crystal dimensions 3" x 3" was used to calculate the concentration of Radium, Thorium and Potassium.

Assessment of tracheobronchial and lung dose due to radon and thoron inhalation.

The main sources of natural background radiation are radon, thoron and their progeny, which may cause health risks to humans. Keeping in mind the importance of the subject, three samples each from 10 selected residential areas, including the centre of Babylon Governorate, Iraq, and its districts, were collected. Concentration of radon and thoron was measured using solid-state track detectors (CR-39).

Cannabinol modulates the endocannabinoid system and shows TRPV1-mediated anti-inflammatory properties in human keratinocytes.

Cannabinol (CBN) is a secondary metabolite of cannabis whose beneficial activity on inflammatory diseases of human skin has attracted increasing attention. Here, we sought to investigate the possible modulation by CBN of the major elements of the endocannabinoid system (ECS), in both normal and lipopolysaccharide-inflamed human keratinocytes (HaCaT cells). CBN was found to increase the expression of cannabinoid receptor 1 (CB) at gene level and that of vanilloid receptor 1 (TRPV1) at protein level, as well as their functional activity.

Association between rs1799983 polymorphism of eNOS gene and essential hypertension in Iraqi hypertensive patients.

Objective: Aim: To investigate allele frequencies of rs1799983 polymorphism eNOS genes and to determine association between rs1799983 polymorphism of eNOS gene and essential hypertension in Iraqi hypertensive patients.

Patients And Methods: Materials and Methods: This is an observational cross sectional descriptive single center study. ninety hypertensive patients were recruited by specialist cardiologist and conducted at AL-Diwaniyah teaching hospital and department of pharmacology and therapeutics, college of medicine, university of Al-Qadisiyah, Iraq.

Vitamin D receptor gene rs2228570 (FOKI) polymorphism associated with essential hypertension in Iraqi patients.

Objective: Aim: To understand how vitamin D receptor gene polymorphism (VDR rs2228570) affects blood pressure in Iraqi patients with essential hypertension in Al Diwaniya province.

Patients And Methods: Materials and Methods: This is a single-center observational cross-sectional descriptive study of 90 patients with essential hypertension. Using the PCRTETRA ARM technique, blood samples were genotyped and examined for the polymorphisms of FOKI (rs2228570) gene.

The impact of empagliflozin and metformin on cardiac parameters in patients with mid-range ejection fraction heart failure without diabetes.

Heart failure (HF) remains a significant problem for healthcare systems, requiring the use of intervention and multimodal management strategies. We aimed to assess the short-term effect of empagliflozin (EMPA) and metformin on cardiac function parameters, including ventricular dimension-hypertrophy, septal thickness, ejection fraction (EF), and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in patients with HF and mildly reduced EF. A case-control study included 60 newly diagnosed patients with HF.

Serum Cadmium and Lead Levels in Thalassemic Patients of Najaf Governorate, Iraq.

Thematological is a class of hereditary hematologic illnesses resulting from abnormalities in the production of one or more hemoglobin chains. Patients with β-Thematological may have a reduction in heavy metal levels as a result of iron chelate medication. The aim is to study the levels of heavy metals (toxic) in the blood of beta-Thematological patients and compare them to healthy people for the purpose of arriving at indicators through which it is possible to assist in early diagnosis of this disease or reduce symptoms.

Effects of combined metformin and cabergoline versus metformin alone on ovarian and hormonal activities in Iraqi patients with PCOS and hyperprolactinemia: a randomized clinical trial.

Polycystic ovary syndrome (PCOS) is one of the most prevalent metabolic diseases during female reproductive life, often associated with insulin resistance and hyperprolactinemia. The efficacy of metformin and cabergoline for managing PCOS remains debated in the literature. This three-arm interventional study in Iraq assessed the effects of these drugs on body mass index (BMI), hormonal balance, and uterine artery blood flow in 75 women with PCOS and hyperprolactinemia.

Metformin effects on cardiac parameters in non-diabetic Iraqi patients with heart failure and mid-range ejection fraction - a comparative two-arm parallel clinical study.

Heart failure (HF) remains a difficult challenge to the healthcare system, necessitating promoting interventions and multidrug management. Metformin, typically used to manage diabetes, has emerged as a promising intervention in the treatment of HF. This study aimed to assess the effect of adding metformin to the standard treatment of HF on cardiac parameters.

The association of in-utero exposure to polycyclic aromatic hydrocarbons and umbilical liver enzymes.

Background: The adverse health influences of polycyclic aromatic hydrocarbons (PAHs) exposures have been examined in several previous research. However, the evidence on the health influences of PAHs exposure during pregnancy and childhood is scarce, with no study on the infant's liver function. Therefore, in this study, the association of in-utero exposure to particulate matter-bound PAHs (PM-bound PAHs) on the umbilical liver enzymes was investigated.

Stress as a possible cause of a high incidence of hypertension and diabetes and a low incidence of asthma in the Iraqi population.

Hypertension and diabetes represent a significant public health burden worldwide and are significant risk factors for heart disease and stroke. Nevertheless, Iraqi people, in particular, experience higher levels of stress due to political instability and economic issues. The study aimed to investigate the prevalence of common morbidities among Iraqi patients and the possible relationship with exposure to stress.

Comprehensive review on the efficiency of ionic liquid materials for membrane separation and environmental applications.

In the current twenty years, industrial applications of ionic liquids (ILs) have been of paramount attention due to their indisputable positive characteristics like negligible volatility and chemical/thermal stability. These brilliant advantages open new horizons towards environmentally friendly application of ILs in several industrial activities like membrane-based CO separation, electrolyte, bioprocessing, targeted drug delivery and solar panels. The principal intention of this article is to prepare a comprehensive review on the potential efficiency of IL-based absorbents to separate CO acidic contaminant from industrial gaseous streams compared to alkanolamine absorbents as the benchmark.

Hepatorenal protective activity of Artemisia against diclofenac toxicity in male rats.

Introduction: Artemisia is one of the important alternative treatments for many diseases, as well as the prevention of the effect of oxidizing substances that cause damage to the various organs of the body, including the liver and kidneys. The kidney and the liver are considered the body's most critical organs, and their functions in storage, metabolism, detoxification and elimination of medications, and their metabolic products make them target structures for "drug-induced" harm. The goal of this investigation was to see if Artemisia extract might protect hepatic and renal tissues from diclofenac-induced damage.

Rare Phytocannabinoids Exert Anti-Inflammatory Effects on Human Keratinocytes via the Endocannabinoid System and MAPK Signaling Pathway.

Increasing evidence supports the therapeutic potential of rare cannabis-derived phytocannabinoids (pCBs) in skin disorders such as atopic dermatitis, psoriasis, pruritus, and acne. However, the molecular mechanisms of the biological action of these pCBs remain poorly investigated. In this study, an experimental model of inflamed human keratinocytes (HaCaT cells) was set up by using lipopolysaccharide (LPS) in order to investigate the anti-inflammatory effects of the rare pCBs cannabigerol (CBG), cannabichromene (CBC), Δ-tetrahydrocannabivarin (THCV) and cannabigerolic acid (CBGA).

Treatment of Meniere's disease by Multi-session Dexamethasone Injections.

Background: Meniere's Disease (MD) is a complex and multifactorial inner ear problem characterized by episodic vertigo, unilateral sensori-neural hearing loss and tinnitus or fullness in the ear due to Endolymphatic hydrops. There are multiple treatment options available for this disease; from which cortisone therapy can be given in different routes and in different doses.

Objectives: is to identify the successfulness of treatment of MD by multi-session intra-tympanic dexamethasone injection compared to the single-session method.

Computational Investigations of Traditional Chinese Medicinal Compounds against the Omicron Variant of SARS-CoV-2 to Rescue the Host Immune System.

Macrodomain-I of the NSP3 (non-structural protein 3) is responsible for immune response hijacking in the SARS-CoV-2 infection known as COVID-19. In the omicron variant (B.1.