ADAMTS4-Specific MR Peptide Probe for the Assessment of Atherosclerotic Plaque Burden in a Mouse Model.

Introduction: Atherosclerosis is the underlying cause of multiple cardiovascular pathologies. The present-day clinical imaging modalities do not offer sufficient information on plaque composition or rupture risk. A disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) is a strongly upregulated proteoglycan-cleaving enzyme that is specific to cardiovascular diseases, inter alia, atherosclerosis.

Prevalence and Characteristics of Dyslipidemia in a Hospital in Madagascar.

Introduction Dyslipidemia is a major risk factor for atherosclerosis and is included in the metabolic syndrome. Data on dyslipidemia are still lacking in some parts of Africa. Our objectives were to report the prevalence of dyslipidemia and to describe the lipid profile of patients in a hospital in Madagascar.

Advancing toxicovigilance of recreational drugs, including new psychoactive substances, by using data from four European poison centres.

Introduction: Common recreational drugs and new psychoactive substances pose challenges to public health. This study investigated the feasibility of merging cases of recreational drug poisoning reported to European poison centres.

Methods: Four European poison centres (Freiburg, Germany; the Netherlands; Sweden and Switzerland) collaborated in a retrospective, observational study.

Sole and co-exposure toxicity of commercial formulations ethoprophos and bispyribac-sodium to Oreochromis niloticus: Assessment of oxidative stress, genotoxicity, and gill ultrastructure.

Aquatic organisms are simultaneously exposed to multiple hazardous chemicals that can be released into water bodies. The current study aimed to evaluate the effect of sublethal concentration (1/50 96 h-LC) of two formulated pesticides: ethoprophos, bispyribac-sodium, and their combination for 1, 2, 3, and 4 weeks on oxidative stress, genotoxic response, and gill morphology in Nile tilapia. This study is the first to demonstrate the toxic effects of ethoprophos and bispyribac-sodium mixture on the commercial important species, Oreochromis niloticus.

Germline genetic testing for prostate cancer: Ordering trends in the era of expanded hereditary cancer screening recommendations.

Purpose: The availability of targeted therapies for advanced prostate cancer led to the expansion of national guidelines recommending germline genetic testing. The aim of this study was to describe recent trends in germline test ordering patterns for patients with prostate cancer.

Materials And Methods: A retrospective cohort analysis of patients with prostate cancer who underwent germline testing through a single commercial laboratory (Invitae Corporation) between 2015-2020 was performed.

Effectiveness of Childbirth Self-Efficacy Enhancing Classes on Labor Length and Outcomes among Egyptian Primiparous Women: A Quasi-Experimental Study.

Introduction: Childbirth self-efficacy has repeatedly been shown to raise satisfaction with childbirth, reduce the need for analgesic, and promote the use of different childbirth alternatives. However, the measures to improve the childbirth self-efficacy had rarely been investigated among Egyptian primiparous women.

Aim: The aim of this study is to evaluate the effectiveness of childbirth self-efficacy enhancing classes on labor length and outcomes among Egyptian primiparous women.

Large Language Models for Simplified Interventional Radiology Reports: A Comparative Analysis.

Purpose: To quantitatively and qualitatively evaluate and compare the performance of leading large language models (LLMs), including proprietary models (GPT-4, GPT-3.5 Turbo, Claude-3-Opus, and Gemini Ultra) and open-source models (Mistral-7b and Mistral-8×7b), in simplifying 109 interventional radiology reports.

Methods: Qualitative performance was assessed using a five-point Likert scale for accuracy, completeness, clarity, clinical relevance, naturalness, and error rates, including trust-breaking and post-therapy misconduct errors.

Phosphoinositide 3-Kinase Inhibitors from Gladiolus Segetum Ker-Gawl Corms Supported by Network Pharmacology.

Gladiolus segetum Ker-Gawl corms total extract exhibited remarkable in vitro anti-proliferative effects against panel of cancer cell lines; including human colon carcinoma (Caco-2), human breast cancer (MCF7) and hepatocellular carcinoma (HepG2) cell lines with IC values of 7.4, 9.1 and 11.

Elastin-specific MR probe for visualization and evaluation of an interleukin-1β targeted therapy for atherosclerosis.

Atherosclerosis is a chronic inflammatory condition of the arteries and represents the primary cause of various cardiovascular diseases. Despite ongoing progress, finding effective anti-inflammatory therapeutic strategies for atherosclerosis remains a challenge. Here, we assessed the potential of molecular magnetic resonance imaging (MRI) to visualize the effects of 01BSUR, an anti-interleukin-1β monoclonal antibody, for treating atherosclerosis in a murine model.

Correction: Computation of soliton structure and analysis of chaotic behaviour in quantum deformed Sinh-Gordon model.

[This corrects the article DOI: 10.1371/journal.pone.

Computation of soliton structure and analysis of chaotic behaviour in quantum deformed Sinh-Gordon model.

Soliton dynamics and nonlinear phenomena in quantum deformation has been investigated through conformal time differential generalized form of q deformed Sinh-Gordon equation. The underlying equation has recently undergone substantial amount of research. In Phase 1, we employed modified auxiliary and new direct extended algebraic methods.

Intravitreal Infliximab for the Treatment of Proliferative Vitreoretinopathy (FIXER): A Randomized Controlled Phase II Trial.

Objective: To study the safety and efficacy of intravitreal infliximab administered at the conclusion of pars plana vitrectomy (PPV) in the treatment of proliferative vitreoretinopathy (PVR) associated with rhegmatogenous retinal detachment (RRD).

Design: Randomized controlled phase II clinical trial.

Subjects: Patients with primary RRD and grade C PVR, according to the updated Retina Society Classification.

Repeated Injection of Very Small Superparamagnetic Iron Oxide Particles (VSOPs) in Murine Atherosclerosis: A Safety Study.

Citrate-coated electrostatically stabilized very small superparamagnetic iron oxide particles (VSOPs) have been successfully tested as magnetic resonance angiography (MRA) contrast agents and are promising tools for molecular imaging of atherosclerosis. Their repeated use in the background of pre-existing hyperlipidemia and atherosclerosis has not yet been studied. This study aimed to investigate the effect of multiple intravenous injections of VSOPs in atherosclerotic mice.

Sensitivity of magnetic resonance elastography to extracellular matrix and cell motility in human prostate cancer cell line-derived xenograft models.

Prostate cancer (PCa) is a significant health problem in the male population of the Western world. Magnetic resonance elastography (MRE), an emerging medical imaging technique sensitive to mechanical properties of biological tissues, detects PCa based on abnormally high stiffness and viscosity values. Yet, the origin of these changes in tissue properties and how they correlate with histopathological markers and tumor aggressiveness are largely unknown, hindering the use of tumor biomechanical properties for establishing a noninvasive PCa staging system.

Noncovalent Functionalization of Graphene Nanoplatelets and Their Applications in Supercapacitors.

We demonstrate a simple noncovalent functionalization technique, which involves graphite exfoliation and subsequent coating of the resulting graphene nanoplatelets (GNPs) with trimellitic anhydride (TMA), using a thermomechanical exfoliation process. TMA adsorbs on the surface of the GNPs, resulting in a reduction of the specific surface area to 312 ± 9 m/g compared to 410 ± 12 m/g for the unmodified GNPs. Detailed imaging, thermogravimetric, and X-ray diffraction analysis showed that the modified GNPs (TMA-GNPs) maintain similar structure to the unmodified GNPs.

Enhancement of antibacterial and UV protection properties of blended wool/acrylic and silk fabrics by dyeing with the extract of leaves and metal salts.

In response to the heightened awareness of infectious diseases and the growing emphasis on personal protection in daily life, the utilization of natural bioresources for textile fabric dyeing has garnered substantial research attention. This is particularly due to their ability to confer antibacterial and UV protection properties to fabrics. In this study, the dyeing properties of Linn extract, alone and mordanted, were evaluated on blended wool/acrylic and silk fabrics, along with an assessment of their antibacterial and UV protection characteristics.

The role of self-efficacy in women's autonomy for health and nutrition decision-making in rural Bangladesh.

Background: Agency - including the sub-domains of intrinsic agency, instrumental agency, and collective agency - is a critical component of the women's empowerment process. Self-efficacy (a component of intrinsic agency) may operate as a motivational influence for women to make choices according to their own preferences or goals, such that higher self-efficacy would be associated with more autonomous decision-making (a key component of instrumental agency).

Methods: We examine these relationships using mixed methods.

The Status of Students, Faculty, and Leadership Diversities in US Pharmacy Schools/Colleges.

Objective: The purpose of this research is to address knowledge gaps on diversity in the United States (US) population, pharmacy students, faculty, and school/college leadership.

Method: The population data were collected from the US Census Bureau. The pharmacy student and faculty data were collected from the American Association of Colleges of Pharmacy enrollment and faculty profiles to compute Diversity Indices (DIs).

Impact of a Homestead Food Production Program on Dietary Diversity: Seasonal and Annual Results from the Cluster-Randomized FAARM Trial in Sylhet, Bangladesh.

Background: Rice-predominant diets are common in Bangladesh, leading to widespread nutritional deficiencies. The Food and Agricultural Approaches to Reducing Malnutrition (FAARM) cluster-randomized controlled trial in rural Sylhet, Bangladesh evaluated a homestead food production intervention implemented 2015-2018 through Helen Keller International, aiming to improve child growth.

Objectives: We estimated the intervention's impact on women's and children's dietary diversity, a secondary trial objective.

Challenges in Managing Paediatric Crohn's Disease With Crohn's Disease Exclusion Diet (CDED): The First Single-Center Study in the United Arab Emirates.

Background: Inflammatory bowel disease has been increasing significantly. For that, many modalities of treatment have shown promising results including a special diet. In our study, we looked at Crohn's disease dietary management for induction and subsequently maintenance of treatment.

Diabetes Distress and Self-Care Activities Among Patients With Diabetes Type II: A Correlation Study.

Introduction: Diabetes mellitus (DM) is a main, highly prevalent, and challenging public health issue. Suboptimal self-care for type II diabetes can lead to poor glycemic control, complications, and even death.

Objective: This study investigated the incidence of distress and its link with self-care habits of patients with diabetes type II.

Effect of a Homestead Food Production Program on the Prevalence of Diarrhea and Acute Respiratory Infection in Children in Sylhet, Bangladesh: A Cluster-Randomized Controlled Trial.

Diarrhea and respiratory illness are leading causes of mortality and morbidity among young children. We assessed the impact of a homestead food production intervention on diarrhea and acute respiratory infection (ARI) in children in Bangladesh, secondary outcomes of the Food and Agricultural Approaches to Reducing Malnutrition (FAARM) cluster-randomized trial. The trial enrolled 2,705 married women and their children 3 years or younger in 96 rural settlements (geographic clusters) in Sylhet Division, Bangladesh.

Diabetic microaneurysms detected by fluorescein angiography spatially correlate with regions of macular ischemia delineated by optical coherence tomography angiography.

Purpose: To characterize the relationship between diabetic macular ischemia (DMI) delineated by optical coherence tomography angiography (OCTA) and microaneurysms (MAs) identified by fundus fluorescein angiography (FFA).

Methods: Patients with diabetic retinopathy (DR) who underwent OCTA and FFA were retrospectively identified. FFA images were cropped and aligned with their respective OCTA images using i2k Align Retina software (Dual-Align, Clifton Park, NY, USA).

Thalassemia and hemoglobinopathy prevalence in a community-based sample in Sylhet, Bangladesh.

Background: Inherited blood disorders affect 7% of the population worldwide, with higher prevalences in countries in the "thalassemia belt," which includes Bangladesh. Clinical management options for severely affected individuals are expensive; thus, targeted government policies are needed to support prevention and treatment programs. In Bangladesh, there is a lack of data, in particular community-based estimates, to determine population prevalence.