Publications by authors named "Kaden S DiMarco"
The early-life gut microbiome development has long-term health impacts and can be influenced by factors such as infant diet. Human milk oligosaccharides (HMOs), an essential component of breast milk that can only be metabolized by some beneficial gut microorganisms, ensure proper gut microbiome establishment and infant development. However, how HMOs are metabolized by gut microbiomes is not fully elucidated.
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- Learning to assess favorable and unfavorable options is vital for survival, and engineered mice studies reveal that the striosome compartment of the striatum plays a key role in this learning process.
- Calcium imaging shows that the activity in striosomes correlates with the learning outcomes, indicating they are crucial for discrimination and task engagement, which can be manipulated with specific genetic techniques.
- Aging and Huntington's disease negatively affect striosomal function in learning, although there's enhanced connectivity between fast-spiking interneurons and striatal projection neurons in mice that successfully learn, suggesting these interneurons help improve signal clarity necessary for effective discrimination.