Investigating the Equivalent Plastic Strain in a Variable Ring Length and Strut Width Thin-Strut Bioresorbable Scaffold.

Purpose: The ArterioSorb[Formula: see text] bioresorbable scaffold (BRS) developed by Arterius Ltd is about to enter first in man clinical trials. Previous generations of BRS have been vulnerable to brittle fracture, when expanded via balloon inflation in-vivo, which can be extremely detrimental to patient outcome. Therefore, this study explores the effect of variable ring length and strut width (as facilitated by the ArterioSorb[Formula: see text] design) on fracture resistance via analysis of the distribution of equivalent plastic strain in the scaffold struts post expansion.

Exploring a parallel rheological framework to capture the mechanical behaviour of a thin-strut polymeric bioresorbable coronary scaffold.

Computational modelling of bioresorbable scaffolds (BRS) has employed several different material property models, ranging from those based on simple elasto-plastic theory through to anisotropic parallel network models that capture the viscoelastic-plastic behaviour observed in poly-l-lactic acid (PLLA). The increased complexity of higher fidelity material models, particularly in terms of calibration to in-vitro data, can limit their use. Consequently, their suitability for predicting the mechanical response of next-generation BRS is not well understood.

Investigating the material modelling of a polymeric bioresorbable scaffold via in-silico and in-vitro testing.

The accurate material modelling of poly-l-lactic acid (PLLA) is vital in conducting finite element analysis of polymeric bioresorbable scaffolds (BRS) to investigate their mechanical performance and seek improved scaffold designs. To date, a large variety of material models have been utilised, ranging from simple elasto-plastic models to high fidelity parallel network models. However, no clear consensus has been reached on the appropriateness of these different models and whether simple, less computationally expensive models can serve as acceptable approximations.

Preclinical evaluation of a thin-strut bioresorbable scaffold (ArterioSorb): acute-phase invasive imaging assessment and hemodynamic implication.

Aims: The aim of this study was to assess the acute performance of the 95 µm ArterioSorb oriented poly L-lactic acid (PLLA) scaffold in comparison with the XIENCE metallic drug-eluting stent (DES) in porcine coronary arteries.

Methods And Results: In 15 non-atherosclerotic Yucatan mini pigs, the ArterioSorb (3.0/14 mm) and XIENCE (3.

Post-implantation shear stress assessment: an emerging tool for differentiation of bioresorbable scaffolds.

Optical coherence tomography based computational flow dynamic (CFD) modeling provides detailed information about the local flow behavior in stented/scaffolded vessel segments. Our aim is to investigate the in-vivo effect of strut thickness and strut protrusion on endothelial wall shear stress (ESS) distribution in ArterioSorb Absorbable Drug-Eluting Scaffold (ArterioSorb) and Absorb everolimus-eluting Bioresorbable Vascular Scaffold (Absorb) devices that struts with similar morphology (quadratic structure) but different thickness. In three animals, six coronary arteries were treated with ArterioSorb.

Coronary stents seeded with human trophoblastic endovascular progenitor cells show accelerated strut coverage without excessive neointimal proliferation in a porcine model.

The success of percutaneous coronary intervention (PCI) has been limited by restenosis and stent thrombosis. Delayed or incomplete endothelial regeneration is believed to be a key factor responsible for these events. Developing a stent with an accelerated healing profile may be of benefit.

A hydrophilic technology for intermittent urinary catheters.

A biocompatible and highly lubricous hydrophilic coating has been developed for intermittent urinary catheters. The coating has additives incorporated into it, which reduce the drying out of the catheter when it is inserted into the urethra, and antimicrobial agents can be incorporated into it to minimise the trauma associated with catheterisation.

Polymer coating techniques for drug-eluting stents.

As the use of coronary stents continues to expand worldwide, in-stent restenosis remains a major clinical problem for interventional cardiologists. However, recent clinical trials have shown that the drug-eluting stents are the most promising method for reducing the restenosis and allowing the injured vessel to heal. Further development work is focused on investigating the use of this technology with a range of drugs for the inhibition of restenosis.