Publications by authors named "Kadajji Veeran Gowda"
Objective of the present study was to develop a proliposomal formulation to decrease the hepatic first-pass metabolism of a highly metabolized drug. Lovastatin was chosen as the model drug. Proliposomes were prepared by mixing different ratios of phospholipids such as soy phosphatidylcholine (SPC), hydrogenated egg phosphatidylcholine (HEPC) and dimyristoyl phosphatidylglycerol (DMPG) individually with drug and cholesterol in an organic solvent.
View Article and Find Full Text PDFObjective: A randomized, two-way crossover study was conducted in 24 fasting healthy male volunteers of Indian origin to compare the bioavailability of two brands of a fixed dose combination of escitalopram oxalate (CAS 219861-08-2) 10 mg and clonazepam (CAS 1622-61-3) 0.5 mg tablets, using Estomine-zee as test and a commercially available formulation as the reference product. The pharmacokinetics of escitalopram oxalate and clonazepam individually after oral administration of tablet formulation has been extensively evaluated in adult volunteers.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the bioavailability of two sustained release fixed-dose combination products containing esomeprazole and domperidone in 24 healthy male volunteers.
- It utilized a randomized, balanced, open-label, 2-period cross-over design, allowing participants to receive both formulations with a 7-day wash-out period in between.
- Results showed no significant differences in pharmacokinetic parameters between the products, indicating they are bioequivalent, and both were well tolerated without adverse reactions.