A Comparison of Vancomycin Area Under the Curve and Trough Concentration in Specific Populations.

Vancomycin is an antibiotic known to cause nephrotoxicity, particularly when a vancomycin trough of 15 to 20 mg/L, a surrogate for an area under the curve (AUC) of at least 400 mgh/L, is targeted. Although monitoring vancomycin AUC is more resource intensive, it may especially benefit populations expected to be at higher risk of nephrotoxicity. To describe the proportion of discordance between vancomycin AUC and trough concentration in targeted high-risk populations.