Association of body mass index and long-term mortality in patients from nationwide LIPIDOGRAM 2004-2015 cohort studies: no obesity paradox?

Background: An obesity paradox has been described in relation to adverse clinical outcomes (e.g., mortality) with lower body mass index (BMI).

Metabolic syndrome is associated with similar long-term prognosis in those living with and without obesity: an analysis of 45 615 patients from the nationwide LIPIDOGRAM 2004-2015 studies.

Aims: We aimed to evaluate the association between metabolic syndrome (MetS) and long-term all-cause mortality.

Methods And Results: The LIPIDOGRAM studies were carried out in the primary care in Poland in 2004, 2006, and 2015. MetS was diagnosed based on the National Cholesterol Education Program, Adult Treatment Panel III (NCEP/ATP III), and Joint Interim Statement (JIS) criteria.

Increased expression of ORMDL3 in allergic asthma: a case control and in vitro study.

Background: Asthma is the most frequent chronic disease in children. One of the most replicated genetic findings in childhood asthma is the gene confirmed in several GWA studies in several pediatric populations.

Objectives: The purpose of this study was to analyze variants and expression in childhood asthma in the Polish population.

The Landscape of Transmembrane Protein Family Members in Head and Neck Cancers: Their Biological Role and Diagnostic Utility.

Transmembrane proteins (TMEM) constitute a large family of proteins spanning the entirety of the lipid bilayer. However, there is still a lack of knowledge about their function or mechanism of action. In this study, we analyzed the expression of selected genes in patients with head and neck squamous cell carcinoma (HNSCC) to learn their role in tumor formation and metastasis.