Publications by authors named "Kacper Boron"
Background: Breast cancer remains a leading cause of mortality among women, driven by the molecular complexity of its various subtypes. This study aimed to investigate the differential expression of genes and miRNAs involved in the PI3K/AKT/mTOR signaling pathway, a critical regulator of cancer progression.
Methods: We analyzed tumor tissues from five breast cancer subtypes-luminal A, luminal B HER2-negative, luminal B HER2-positive, HER2-positive, and triple-negative breast cancer (TNBC)-and compared them with non-cancerous tissues.
Background/objectives: In this study, serum selenium levels in patients with Crohn's disease (CD) and ulcerative colitis (UC) were evaluated to identify potential predictive markers of disease activity. Conducted in 100 inflammatory bowel disease (IBD) patients (54 CD, 46 UC) and 100 healthy controls, this research provides novel insights through focusing on the regional selenium status of people with IBD in the Polish population, a demographic with limited existing data.
Methods: Selenium concentrations were measured using inductively coupled plasma mass spectrometry (ICP-MS).
Article Synopsis
- The study aimed to identify microRNAs (miRNAs) that may influence SMAD protein activity in different subtypes of breast cancer in Polish women, analyzing five subtypes: luminal A, luminal B HER2-, luminal B HER2+, non-luminal HER2+, and TNBC.
- Using various molecular analysis techniques, the researchers found overexpression of SMAD3 and SMAD5 in all breast cancer types, potentially linked to reduced levels of miR-145, while SMAD7 was underexpressed, possibly due to lower activity of miR-15b and miR-21b.
- Overall, the findings suggest that excessive SMAD protein activation may lead to tumor growth
This study aimed to assess the expression profile of messenger RNA (mRNA) and microRNA (miRNA) related to the dopaminergic system in five types of breast cancer in Polish women. Patients with five breast cancer subtypes were included in the study: luminal A ( = 130), luminal B ( = 196, including HER2-, = 100; HER2+, = 96), HER2+ ( = 36), and TNBC ( = 43); they underwent surgery, during which tumor tissue was removed along with a margin of healthy tissue (control material). The molecular analysis included a microarray profile of mRNAs and miRNAs associated with the dopaminergic system, a real-time polymerase chain reaction preceded by reverse transcription for selected genes, and determinations of their concentration using enzyme-linked immunosorbent assay (ELISA).
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- The study investigates the impact of adalimumab and cyclosporine A on histamine-related gene expression in human keratinocyte cells (HaCaT) stimulated by bacterial lipopolysaccharide (LPS).
- Treatment with LPS was followed by adalimumab or cyclosporine A application, and analyses included RNA extraction and various assays to assess gene regulation.
- Results showed that certain microRNAs related to histamine receptor regulation were downregulated in response to treatments, but additional research is needed to clarify the mechanisms involved in modulating the histaminergic system in psoriasis.