PARP inhibition radiosensitizes BRCA1 wildtype and mutated breast cancer to proton therapy.

Aggressive breast cancers often fail or acquire resistance to radiotherapy. To develop new strategies to improve the outcome of aggressive breast cancer patients, we studied how PARP inhibition radiosensitizes breast cancer models to proton therapy, which is a radiotherapy modality that generates more DNA damage in the tumor than standard radiotherapy using photons. Two human BRCA1-mutated breast cancer cell lines and their isogenic BRCA1-recovered pairs were treated with a PARP inhibitor and irradiated with photons or protons.

Retroperitoneal leiomyosarcoma diagnosis and management in a chronic kidney disease context: A case report.

Introduction And Importance: While the treatment approach for sarcomas seems straightforward and well-defined, we often encounter several diagnostic or therapeutic challenges in clinical practice. This article presents a case of retroperitoneal leiomyosarcoma in a patient with chronic kidney disease, highlighting the complexity of managing such cases.

Case Report: A 63-year-old woman with a history of chronic kidney disease presented with a progressively enlarging mass in her right flank.

Anorectal melanoma: A case report of an unusual localization.

Introduction And Importance: Primary anorectal melanoma (ARM) is a rare neoplasm with an extremely poor prognosis. It represents less than 1 % of all melanomas and accounts for less than 1 % of anorectal malignancies. We report a case of anorectal primary melanoma treated surgically.

An empirical model of carbon-ion relative biological effectiveness based on the linear correlation between radiosensitivity to photons and carbon ions.

To develop an empirical model to predict carbon ion (C-ion) relative biological effectiveness (RBE).We used published cell survival data comprising 360 cell line/energy combinations to characterize the linear energy transfer (LET) dependence of cell radiosensitivity parameters describing the dose required to achieve a given survival level, e.g.

Hook-shaped distal common bile duct due to peptic ulcer mimicking cholangiocarcinoma.

Introduction And Importance: Internal and spontaneous bilio-digestive fistulas, without primary biliary disease, are an infrequent complication of the upper digestive tract. We report a case of a Hook-shaped distal common bile duct due to peptic ulcer mimicking cholangiocarcinoma.

Case Report: A 63-year-old patient, with no medical history, presented to the emergency department with recent jaundice.

Impact of pharmaceutical and non-pharmaceutical interventions on COVID-19 in Tunisia.

Background: In COVID-19 management, a variety of pharmaceutical interventions (PI) and non- pharmaceutical interventions (NPI) were adopted to limit the spread of the disease and its associated deaths. We aimed to evaluate the impact of PI and NPI on risks of COVID-19 transmission and deaths.

Method: We collected aggregate data from March 2nd, 2020, to December 1, 2022 from the Tunisian Ministry of Health's website and OurWorldInData.

ATR inhibition radiosensitizes cells through augmented DNA damage and G2 cell cycle arrest abrogation.

Ataxia telangiectasia and Rad3-related protein (ATR) is a key DNA damage response protein that facilitates DNA damage repair and regulates cell cycle progression. As such, ATR is an important component of the cellular response to radiation, particularly in cancer cells, which show altered DNA damage response and aberrant cell cycle checkpoints. Therefore, ATR's pharmacological inhibition could be an effective radiosensitization strategy to improve radiotherapy.

Combining Gram stain and 16S qPCR improved diagnostic accuracy for suspected pneumonia and could become a new metric in the rapid diagnosis of lower respiratory tract infections.

The frequency of multidrug-resistant organisms (MDROs) in hospitals and the risk of delaying effective treatment result in the culture of respiratory secretions for nearly all patients with suspected pneumonia. Culture delays contribute to over prescribing and use of broader spectrum antibiotics. The need for improved rapid diagnostics for early assessment of suspected hospital pneumonia.

Case Report: The first reported case of pulmonary alveolar proteinosis with myasthenia gravis in a 27-year-old patient.

Pulmonary alveolar proteinosis is a very rare diffuse lung disease characterized by the accumulation of amorphous and periodic acid Schiff-positive lipoproteinaceous material in the alveolar spaces due to impaired surfactant clearance by alveolar macrophages. Three main types were identified: Autoimmune, secondary and congenital. Pulmonary alveolar proteinosis has been previously reported to be associated with several systemic auto-immune diseases.

Case Report: A very rare case of a Pleural Effusion revealing Multiple Myeloma.

Multiple myeloma is a common malignant bone-based disease. Pleural effusions reported in these patients remain rare. It is commonly due to congestive heart disease, pulmonary embolism, nephrotic syndrome or a second neoplasia.

Incidence and risk factors of post COVID-19 syndrome: a Tunisian cohort study.

Background: It has become increasingly clear that SARS-CoV-2 infection can lead to persistent physical and mental health problems lasting weeks or months, requiring prolonged periods of clinical care and increasing the burden on the healthcare system. This phenomenon, known as post COVID-19 syndrome (PCS), is a relatively new condition, its incidence is still unclear and differs between studies.

Objectives: In this cohort study, we aimed to estimate the incidence of PCS and to identify its risk factors in the Tunisian population.

Ileal duplication in adults: A rare case.

Introduction And Importance: Intestinal duplication is an uncommon congenital malformation affecting the alimentary tract. This article presents a case of enteric duplication cyst (EDC) in an adult, accompanied by a review of the available literature.

Case Presentation: A 34-year-old woman with polymyositis underwent a routine CT scan as part of her medical assessment revealing an 8 cm mass near the caecum and terminal ileum.

Protection of natural infection against reinfection with SARS-CoV-2 JN.1 variant.

Overall effectiveness of infection in preventing reinfection with SARS-CoV-2 JN.1 variant was estimated at 1.8% (95% CI: −9.

Comparison of time to negative conversion of SARS-CoV-2 between young and elderly among asymptomatic and mild COVID-19 patients: a cohort study from a national containment center.

Objective: We aimed to study the relationship between age and time to negative conversion of SARS-CoV-2 in patients with asymptomatic and mild forms of COVID-19.

Methods: We conducted a cohort study including all patients diagnosed with COVID-19 from the national COVID-19 containment center of Tunisia. Patients were subdivided into two cohorts: (under 60 years) and (over 60 years) and were followed up until PCR negativization.

Torsion of funiculocele presenting as an incarcerated hernia: A rare case.

Introduction: Inguinal hernia is common, but the groin area can host various pathologies. Distinguishing clinically between hernias and rare conditions like torsion of funiculocele poses challenges due to similar presentations.

Case Presentation: A 50-year-old man, with a 10-year-history of a groin mass, presented with a painful groin mass, initially diagnosed as a strangulated hernia.

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Introduction: Tunnel enlargement following anterior cruciate ligament (ACL) reconstruction has been frequently reported since the nineties, yet its etiologies remain unclear.

Aim: To elucidate the factors favoring this phenomenon and to investigate its clinical and anatomical consequences.

Methods: This was a descriptive retrospective study conducted on 37 patients who underwent ACL reconstruction surgery using single-bundle hamstring tendons with fixation using absorbable interference screws at the Traumatology Department of the Kassab National Institute of Orthopedics.

Jejunogastric intussusception associated with jejunojejunal intussusception (double telescoping) occurring 20 years after gastrojejunostomy.

Introduction: Jejunogastric intussusception (JGI) is a rare but potentially lethal complication following gastrectomy or gastrojejunostomy surgeries. Diagnosis of this condition can be challenging due to its rarity and non-specific symptoms. This article presents a case report of a 60-year-old male with a history of trans mesocolic gastrojejunostomy who developed acute symptoms of JGI.

A retroperitoneal pseudomyxoma of the appendix: A case report.

Introduction: Retroperitoneal pseudomyxoma (RP) is a rare condition characterized by mucinous tumor growth within the retroperitoneal space, commonly originating from the appendix or other abdominal organs. RP presents with non-specific symptoms such as abdominal pain, bloating, and weight loss, making accurate diagnosis challenging. Due to its rarity and symptom overlap with other conditions, RP requires careful management by a multidisciplinary healthcare team.

A case report of intestinal acute intussusception secondary to a lipoma: Imagery has a great value.

Introduction: Acute intestinal intussusception (AII) in adults, unlike in children, is a rare manifestation that is frequently secondary to malignant or benign tumors and intestinal intussusception on a lipoma is more exceptional.

Case Presentation: We present a rare case of AII caused by a lipoma in a previously healthy 44-year-old man. He experienced severe right lower quadrant pain and constipation.

Incidental pneumoperitoneum due to pneumatosis intestinalis: A rare case of benign pneumoperitoneum.

Introduction And Significance: Pneumatosis intestinalis (PI), the presence of gas within the intestinal wall, is a rare but significant gastrointestinal condition. It may be associated with underlying gastrointestinal disorders or detected incidentally, posing diagnostic challenges. This article emphasizes the importance of recognizing and managing this condition conservatively when appropriate.

Abdominal pseudohernia as an exceptional complication of herpes-zoster.

Introduction: Herpes zoster (HZ), caused by the reactivation of the Varicella-Zoster virus, is typically characterized by sensory complications. However, motor complications, such as abdominal pseudohernia, are rare and exceptional. This report presents a case of post-herpes zoster pseudo-hernia in a previously healthy 54-year-old man.

Dieulafoy's lesion: Is there still a place for surgery? About 2 cases.

Introduction: Dieulafoy's lesion, a rare but life-threatening condition accounting for a small percentage of acute gastrointestinal bleeding cases, has historically posed diagnostic and therapeutic challenges.

Case Presentation: In this article, we present two cases that required surgical intervention due to unsuccessful attempts with endoscopy. Case 1 involved a 40-year-old patient with a history of treated duodenal ulcers, while Case 2 featured a 74-year-old woman with no notable medical history.

Dropped gallstone-related perihepatic abscess 20 years after open cholecystectomy.

Introduction: Gallstone spillage during cholecystectomy is a recognized complication that can lead to various postoperative complications.

Case Presentation: We present a rare case of a gallstone abscess that developed 20 years after an open cholecystectomy. An 80-year-old woman with a history of high blood pressure and previous gallbladder removal presented with severe abdominal pain.