Publications by authors named "Kabuye Deo"
Background: The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood, However. Gene polymorphisms have been associated with PTB development.
Objectives: In this study, we investigated the relationship between LIPA gene polymorphisms and a predisposition to pulmonary tuberculosis caused by Mycobacterium tuberculosis.
Article Synopsis
- Empagliflozin (emp) shows renal protective effects against hyperglycemia-induced injury in human kidney cells, though its mechanism remains unclear.
- High glucose levels increase harmful proteins and signals related to fibrosis, while emp decreases these effects and increases HIF-1α expression, suggesting a potential protective pathway.
- Overall, emp treatment provides a protective role for renal tubular cells under high glucose conditions by reducing injury and influencing important cellular markers.
Background: Pulmonary tuberculosis caused by an intracellular pathogen, Mycobacterium tuberculosis continues to exist as a hazardous disease to human life globally. Genetic polymorphisms regulate resistance and susceptibility to tuberculosis. The C-type lectin receptor of family 4 member E (CLEC4E) confers protection against tuberculosis in laboratory animals but its function in influencing exposure or resistance to pulmonary tuberculosis (PTB) in humans remains obscure.
View Article and Find Full Text PDFA review of urinary angiotensin converting enzyme 2 in diabetes and diabetic nephropathy.
Biochem Med (Zagreb)
February 2019
Urinary angiotensin converting enzyme 2 (ACE2) is significantly increased in diabetes and diabetic nephropathy. While studies on its clinical significance are still underway, its urinary expression, association with metabolic and renal parameters has been in the recent past considerably studied. The recent studies have demystified urine ACE2 in many ways and suggested the roles it could play in the management of diabetic nephropathy.
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