Publications by authors named "Kaburaki T"
Purpose: This study aimed to investigate the clinical characteristics, diagnostic markers, and treatment outcomes of varicella-zoster virus-associated anterior uveitis (VZV-AU) with and without ophthalmic herpes zoster (herpes zoster ophthalmicus (HZO) and zoster sine herpete (ZSH), respectively).
Methods: Clinical records of 47 VZV-AU patients (21 ZSH, 26 hZO) were retrospectively reviewed for clinical findings, medication use, and PCR using aqueous humor (AH) results.
Results: There was no significant difference in age, gender, visual acuity (VA), or intraocular pressure (IOP) between the two groups.
Article Synopsis
- Diabetic retinopathy (DR) is a major cause of vision loss linked to diabetes, prompting a study on the protective effects of pemafibrate in a type 2 diabetes rat model.
- The study involved administering pemafibrate to a group of obese diabetic rats while monitoring their retinal function and health through various examinations, including electroretinography.
- Results indicated that pemafibrate reduced triglycerides and increased good cholesterol, showing improved retinal thickness and larger AQP4-positive areas, suggesting it may help protect against DR.
Intraocular lymphoma (IOL) is a rare malignant intraocular lymphocytic tumor that mimics uveitis. IOL is anatomically classified into vitreoretinal lymphoma (VRL) and uveal lymphoma; most IOLs are VRLs, while uveal lymphoma is rare. VRL is highly malignant, with 60%-85% of patients developing central nervous system (CNS) lymphoma; primary VRL (PVRL) is an ocular disease with poor prognosis.
View Article and Find Full Text PDFPurpose: The purpose of this study was to investigate the impact of prostaglandin D2 (PGD2) receptor 2 (DP2) on choroidal neovascularization (CNV) formation in mice.
Methods: Using a laser-induced CNV model, the CNV size of wild-type (WT) mice treated with DP2 antagonist (CAY10471 or OC000459) was compared with that of untreated mice. Vascular endothelial growth factor (VEGF) and MCP-1 levels were also compared between the two groups.
Purpose: We report and verify a novel hue discrimination instrument. We also investigate its efficiency to determine hue discrimination in persons with normal color vision.
Study Design: Experimental and clinical investigation.
Rationale: Satoyoshi syndrome is a rare systemic autoimmune disease that presents with painful muscle spasms. We report a case of impending central retinal vein occlusion (CRVO) secondary to granulomatous pan-uveitis in a 32-year-old woman with Satoyoshi syndrome.
Patient Concerns: At the age of 7 years, she developed generalized hair loss and painful spasms and was diagnosed with Satoyoshi syndrome.
[This corrects the article DOI: 10.3389/fimmu.2022.
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- - The study assessed the effectiveness and safety of adalimumab (ADA) in treating chronic recurrent Vogt-Koyanagi-Harada (VKH) patients presenting with sunset glow fundus (SGF) over a period of more than 6 months.
- - A review of 50 patient medical records revealed significant improvements in visual acuity, flare counts, and other related measurements after ADA treatment, with a continued treatment rate of 94%.
- - The findings indicate that ADA is effective for remission in VKH patients who have not responded well to typical treatments, with a generally high tolerance for the medication and few serious side effects.
Granular cell tumours (GCTs) are benign tumours that rarely develop in intraocular regions. We report a rare case of intraocular GCT in the ciliary body. A woman in her 20s with a history of bone marrow transplantation for malignant lymphoma in early childhood was referred to our department for bilateral proliferative diabetic retinopathy.
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- The study reported on ocular inflammatory events that occurred after COVID-19 vaccination in Japan, focusing on a case series from 16 hospitals with uveitis clinics.
- A total of 37 patients experienced these events, with a mean age of 53.4 years and symptoms appearing about 6.3 days post-vaccination, most commonly associated with the Pfizer-BioNTech vaccine.
- The findings suggest that healthcare providers should be aware of the potential for these inflammatory reactions as an adverse effect of COVID-19 vaccination.
Human cytomegalovirus (HCMV) infections develop into CMV diseases that result in various forms of manifestations in local organs. CMV-retinitis is a form of CMV disease that develops in immunocompromised hosts with CMV-viremia after viruses in the peripheral circulation have entered the eye. In the HCMV genome, extensive diversification of the UL40 gene has produced peptide sequences that modulate NK cell effector functions when loaded onto HLA-E and are subsequently recognized by the NKG2A and NKG2C receptors.
View Article and Find Full Text PDFPurpose: To investigate the risk of ocular adverse events after Coronavirus Disease 2019 (COVID-19) mRNA vaccination.
Design: Matched cohort and self-controlled case series (SCCS) studies.
Participants: We used a population-based database of medical claims and vaccination records in a large Japanese city.
Article Synopsis
- - The study aimed to explore how different anesthetics affect electroretinogram (ERG) results in Spontaneously Diabetic Torii (SDT) fatty rats and normal Sprague-Dawley (SD) rats.
- - Two anesthetic groups were tested: one with pentobarbital and another with a combination of medetomidine, midazolam, and butorphanol (MMB), measuring various ERG wave characteristics.
- - Results showed that the MMB group had higher a-wave and OP4 amplitudes in SD rats and higher OP1 amplitudes in SDT fatty rats; however, peak times were generally longer with pentobarbital in SD rats.
Factors associated with low prevalence of Fuchs' uveitis syndrome in Japan.
Front Med (Lausanne)
September 2022
Article Synopsis
- The study aimed to investigate the low prevalence of Fuchs' uveitis syndrome (FUS) in Japan by reviewing medical records of 160 patients diagnosed with the condition at uveitis specialty facilities.
- Results showed that a significant number of patients were referred for idiopathic uveitis, cataracts, and glaucoma, with most patients experiencing unilateral symptoms and common findings like anterior inflammation and keratic precipitates.
- The conclusion suggests that the low prevalence of FUS in Japan may be due to misdiagnosis as milder conditions, affecting timely recognition and treatment of the syndrome.
Objectives: Behçet's disease tends to be more severe in men than women. This study was undertaken to investigate sex-specific genetic effects in Behçet's disease.
Methods: A total of 1762 male and 1216 female patients with Behçet's disease from six diverse populations were studied, with the majority of patients of Turkish origin.
Article Synopsis
- The study evaluated the effectiveness and safety of adalimumab (ADA) for patients with Vogt-Koyanagi-Harada (VKH) disease experiencing flare-ups or recurrences.
- In a review of 70 VKH patients treated with ADA for over 6 months, significant improvements were observed in several medical measures, such as reduced choroidal thickness and lower doses of other medications.
- Although some adverse events were reported (17.1%), including cases of tuberculosis and psoriasis, the majority of patients continued with ADA treatment, indicating it is generally well tolerated and effective for managing VKH disease.
Differential diagnosis of lens dislocation includes various ocular and systemic diseases, as well as a history of trauma. The purpose of this study is to report cases of lens dislocation caused by family violence, a social problem that is increasing worldwide. Case 1: a 70-year-old female with narrow anterior chamber and high intraocular pressure in her left eye due to lens dislocation was referred to our hospital after her husband had beaten her with a fist.
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- - This study focused on assessing the safety and effectiveness of adalimumab (Humira) treatment in patients with noninfectious uveitis over a period of up to 52 weeks, across 60 medical facilities in Japan.
- - Out of 251 patients, 27.9% experienced adverse events, with the most common being infections; those over 65 and with preexisting conditions were more affected.
- - Effectiveness measures, such as visual acuity and uveitis recurrence rate, generally improved, and there were no new safety concerns identified, affirming adalimumab's previously established safety profile.
Background: Herpetic anterior uveitis (AU) is usually caused by the herpes simplex virus, varicella-zoster virus, and cytomegalovirus. Herein, we report a case of herpetic AU associated with human herpesvirus 7 (HHV-7) infection.
Study Design: A case report.
A 64-year-old female suffering from lung cancer was treated with crizotinib. Two years later, whitish massive optic disc oedema was observed in the right eye. The fluorescein angiography results were suggestive of uveitis but also revealed leakage from the optic disc, retinal veins, and capillaries in the posterior retina and the periphery.
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- Researchers studied how systemic corticosteroids are used to treat a type of eye inflammation in people with certain diseases in Japan.
- They looked at 157 patients over several years and found that many had to take these steroids for over 300 days to manage their symptoms.
- A lot of patients still had relapses and side effects from the steroids, showing it's tough to lower the doses and control the inflammation.
Purpose: To analyze the incidence of sympathetic ophthalmia (SO) after inciting events (eye trauma or intraocular surgery).
Design: Retrospective cohort study.
Participants: Patients experiencing inciting events between 2012 and 2019.