Mono- and dinuclear oxidovanadium(v) complexes of an amine-bis(phenolate) ligand with bromo-peroxidase activities: synthesis, characterization, catalytic, kinetic and computational studies.

The mono- and dinuclear oxidovanadium(v) complexes [VO(L)(Cl)] (1) and [LVO(μ-O)VO(L)] (2) of ONNO donor amine-bis(phenolate) ligand (HL) were readily synthesized by the reaction between HL and VCl.(THF) or VO(acac) in MeOH or MeCN, respectively, and then characterized through mass spectroscopy, H-NMR and FTIR techniques. Both the complexes possess distorted octahedral geometry around each V centre.

A Smart Molecule for Selective Sensing of Nitric Oxide: Conversion of NO to HSNO; Relevance of Biological HSNO Formation.

A smart molecule, QT, containing thiosemicarbazide moiety acts as a highly selective turn-on in vitro NO sensor through the unprecedented NO-induced transformation of thiosemicarbazide moiety to 1,3,4-oxadiazole heterocycle with the concomitant release of HSNO, thereby eliminating any interference from various endogenous biomolecules including dehydroascorbic acid, ascorbic acid, etc. The kinetic studies of the reactions between QT and NO provide a mechanistic insight into formation of HSNO/RSNO from the reaction between HS/RSH and NO in the biological system. This novel probe is non-cytotoxic, cell permeable, water-soluble, and appropriate for intracellular cytoplasmic NO sensing with the possibilities of in vivo applications.