Bibliometric Analysis of the Role of Occludin in the Pathogenesis of Stroke.

Over the past decade, there has been a notable surge in research dedicated to unraveling the intricate role of tight junction proteins in blood-brain barrier (BBB) damage associated with ischemic stroke. This bibliometric analysis explores the expansive landscape of occludin research, a key tight junction protein, during the years 2000-2023, shedding light on the global scientific contributions, collaborations, and emerging trends in this critical area of stroke pathogenesis. China and the United States emerge as significant contributors, underscoring their prominence in advancing our understanding of tight junction proteins.

ANALYSIS OF RISK FACTORS FOR ISCHEMIC STROKE IN RURAL RESIDENTS OF THE AKTOBE REGION.

Stroke continues to be a major global health concern, accounting for the fifth highest death rate and a sizable portion of the world's disability burden. Over 40,000 stroke cases are reported annually in the Republic of Kazakhstan, of which 5,000 people die within the first 10 days and an additional 5,000 within a month after discharge. Even with the establishment of regional stroke centers, a state anti-stroke program, and substantial efforts, rural communities still experience higher rates of stroke-related morbidity and mortality.

KAZAKH ADAPTATION OF THE MONTREAL COGNITIVE ASSESSMENT (MOCA).

The Montreal Cognitive Assessment (MoCA) is a brief cognitive evaluation tool that has been developed for screening of patients for Mild Cognitive Impairment (MCI). MCI is a recognized high-risk state for Alzheimer's disease development. The aim of the present study was to create a Kazakh-language adaptation of the original version of the Montreal Cognitive Assessment (version 7.

[DIFFERENTIAL DIAGNOSIS AND THERAPY OF PARKONSON'S DISEASE AND ESSENTIAL TREMOR: REVIEW AND CLINICAL CASE].

At present, the problem of differential diagnosis and therapy of Parkinson's disease and essential tremor is one of the topical issues of modern clinical neurology. Despite the nosological independence of these diseases, there is evidence of their pathogenetic relationship. The article presents a review of the results of modern scientific research devoted to the study of criteria for diagnosing Parkinson's disease and essential tremor.

Neuron-Specific Markers and their Correlation with Neurological Scales in Patients with Acute Neuropathologies.

In predicting outcomes in patients with acute brain injury, current practice focuses special attention on neuron-specific proteins that reliably reflect the severity of the lesion. Further studies of molecular markers and their specificity and sensitivity could contribute to broadening the understanding of pathophysiological, diagnostic, and prognostic methods, which is vital to reducing the mortality and disability associated with these critical conditions. The purpose of this study was to assess the biomarkers of brain lesions and their correlative relations with the integral Glasgow Coma Scale (GCS) and National Institutes of Health Stroke Scale (NIHSS) in predicting severity and treatment outcomes in patients with acute neuropathologies.

[PROGNOSTIC VALUE OF BIOMARKERS OF MULTIPLE SCLEROSIS ACTIVITY].

About 30-40% of multiple sclerosis (MS) patients treated with interferon-beta (IFN-ß) develop neutralizing antibodies (NABs) to IFN-ß. NABs reduce bioavailability of IFN-ß, which leads to a decrease in the therapy effectiveness. The introduction of IFN-ß induce production of several proteins, which are used as markers of the therapy effectiveness.

[MODERN APPROACHES TO THE TREATMENT OF MULTIPLE SCLEROSIS (REVIEW AND CLINICAL CASE)].

Multiple sclerosis is a chronic dysimmune neurodegenerative disease of the central nervous system, that affects people of working age and inevitably leads to disability. Treatment of the disease is one of the urgent problems of modern clinical neurology, which is explained by the variety of clinical variants of the flow, the lack of an effective method of treatment. This article is devoted to a review of modern approaches to the issues of etiology, pathogenesis and treatment of multiple sclerosis.

[Rehabilitation of patients in the recovery period after stroke in Kazakhstan].

Aim: To evaluate the effectiveness of complex rehabilitation of post stroke patients in a Stroke Rehabilitation Centre.

Material And Methods: The results of rehabilitative treatment of 86 patients, aged from 50 to 68 years, in early and late recovery periods of ischemic stroke in the middle cerebral artery were analyzed. Neurological deficit was assessed with the Scandinavian Stroke Scale, the dynamics of recovery of neurological disorder with Barthel daily activity index, the degree of misbalance with the modified Rankin scale.

[Work experience of a stroke center in the Western region of Kazakhstan].

Objectives. To analyze results of the work of a regional stroke center in Aktobe city opened in Kazakhstan according to a state program of Health Care development for 2011-2015 years "Healthy Kazakhstan". Material and methods.