Publications by authors named "Kabamba Alexandra"
Article Synopsis
- Broadly neutralising antibodies (bNAbs) like CAP256-VRC26 are being developed to prevent and treat HIV-1, and they require a specific modification (O-sulfated tyrosine) for effectiveness.
- Researchers used glycoengineered Nicotiana benthamiana plants to express two variants of CAP256-VRC26, incorporating the crucial post-translational modifications.
- The modified bNAbs demonstrated similar effectiveness and structural quality to those produced in mammalian cells, showing potential for plant-based systems to enhance HIV treatments through improved antibody production.
