Publications by authors named "Kaat Durink"
Int J Mol Sci
October 2023
Article Synopsis
- Amplification of MYCN occurs in 20-30% of neuroblastoma patients and is linked to poor prognosis, with a transgenic mouse model demonstrating its oncogenic role.
- Mitotic dysregulation is identified as a critical factor in tumor initiation, continuing through tumor progression, with overexpression of mitotic genes found in pre-cancerous neuroblasts.
- Treatment with antimitotic agents significantly delays tumor formation and prolongs survival, while combining these agents with BCL2 inhibitors shows enhanced effectiveness in targeting MYCN-driven neuroblastoma.
