Publications by authors named "Kaat De Clerck"
Article Synopsis
- * The researchers use a light-based method to create vapor nanobubbles (VNBs) with high-intensity laser pulses that can disrupt the ILM, utilizing a photosensitizer called indocyanine green (ICG) in specialized nanoparticles.
- * ICG liposomes were found to produce more VNBs and effectively disrupt the ILM, leading to areas of damage interspersed with intact regions, indicating potential for improved drug delivery strategies through better targeting or nanoparticle design.
Many groundbreaking therapies for the treatment of blindness require delivery of biologics or cells to the inner retina by intravitreal injection. Unfortunately, the advancement of these therapies is greatly hampered by delivery difficulties where obstruction of the therapeutics at the inner limiting membrane (ILM) represents the dominant bottleneck. In this proof-of-principle study, we explore an innovative light-based approach to locally ablate the ILM in a minimally invasive and highly controlled manner, thus making the ILM more permeable for therapeutics.
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