Subperiosteal Ridge Augmentation Technique Utilizing Sticky Bone: A Case Series.

This case series presents the application of a novel minimally invasive technique for augmenting ridge defects across four edentulous sites, thereby circumventing common postoperative complications associated with conventional ridge augmentation techniques. The case series details three cases encompassing four edentulous sites with class I and III ridge defects. This approach uses a minimally invasive subperiosteal technique for ridge augmentation, followed by a delayed implant placement.

Comparative Evaluation of Three Different Demineralisation Protocols on the Physicochemical Properties and Biocompatibility of Decellularised Extracellular Matrix for Bone Tissue Engineering Applications.

Background With three-dimensional (3D) bioprinting emerging as the ultimate pinnacle of personalised treatment for achieving predictable regenerative outcomes, the search for tissue-specific bioinks is on. Decellularised extracellular matrix (DECM), which provides the inherent biomimetic cues, has gained considerable attention. The objective of the present study was to compare the efficacy of three different demineralisation protocols to obtain DECM for bone tissue engineering applications.

Efficacy of a Novel Nanohydrogel Formulation Containing Dopamine, Chitosan Nanoparticles, and Tridax procumbens Extract for Enhanced Wound Healing in Human Gingival Fibroblast Cells: An In Vitro Study.

Background Natural compounds and biomaterials, such as nanohydrogels, have gained interest due to their biocompatibility and tissue regeneration potential. A novel nanohydrogel was prepared by employing , a traditional plant with anti-inflammatory properties and chitosan nanoparticles and a natural bioadhesive with potent antimicrobial and antioxidant effects and dopamine, which has been shown to regulate angiogenesis and influence cell growth. The objective of this study was to examine how human gingival fibroblast (HGF) cells respond to a nanohydrogel formulation containing dopamine, chitosan nanoparticles, and extract in terms of cell viability and cell migration.

Development and Evaluation of Alginate- and Carrageenan-Incorporated Scaffold for Bone Regeneration: An In Vitro Study.

Introduction: Periodontitis, a persistent inflammatory condition, results in the deterioration of both the hard and soft tissues in the periodontium, leading to the formation of intrabony defects. Restoring the lost tissues, particularly bone, is possible through tissue engineering techniques utilizing scaffolds made from different polymers. Consequently, this research focuses on creating and assessing a scaffold infused with alginate (Sigma Aldrich, Gillingham, UK) and carrageenan (Sigma Aldrich, Gillingham, UK) for the purpose of bone regeneration.

Green Synthesis and the Evaluation of Osteogenic Potential of Novel Europium-Doped-Monetite Calcium Phosphate by Cissus quadrangularis.

Background The quest for an ideal bone grafting material has been ongoing for decades. Calcium phosphate, alone or in combination with other materials in natural bone, has been shown to aid in bone regeneration effectively. Monetite exhibits superior solubility and resorption rates among calcium phosphates, rendering it an optimal choice for bone regeneration applications.

Three-Dimensional Bioprinting: The Ultimate Pinnacle of Tissue Engineering.

Three-dimensional (3D) bioprinting has emerged as a revolutionary additive manufacturing technology that can potentially enable life-changing medical treatments in regenerative medicine. It applies the principles of tissue engineering for the printing of tissues and organs in a layer-by-layer manner. This review focuses on the various 3D bioprinting technologies currently available, the different biomaterials, cells, and growth factors that can be utilized to develop tissue-specific bioinks, the different venues for applying these technologies, and the challenges this technology faces.

Development of a Cissus quadrangularis-Doped Extracellular Matrix and a Hyaluronic Acid-Incorporated Scaffold for Periodontal Regeneration: An In Vitro Study.

Purpose: The study aimed to analyze whether adding (CQ) extract and the extracellular matrix of ovine tendon (TENDON) increases the regenerative potential of mesenchymal stem cells produced in hyaluronic acid (HA) scaffolds for tenogenesis.

Materials And Methods: Fifty grams of powdered CQ was mixed with 250 mL of ethanol to prepare the extract. Two grams of hyaluronic acid powder was added to 100 mL of distilled water to make the HA solution.

Hyaluronic Acid Hydrogel Combined With Ocimum sanctum and Tendon-Derived Extracellular Matrix Enhances Tenogenesis in Periodontal Ligament Stem Cells.

Background (OS) is a medicinal plant with antioxidant, anti-cancer, anti-diabetic, antimicrobial, and anti-inflammatory activities. Extracellular matrix (ECM) maintains the structural stability of tissues. Hyaluronic acid (HA), which is used in hydrogel fabrication and osteochondral regeneration, increases cell viability and the expression of marker genes.

A Novel Candidate for Guided Tissue Regeneration: Chitosan and Eggshell Membrane.

Background The primary cause of adult tooth loss is commonly attributed to periodontal disease, a condition that weakens the supportive structures around the teeth. In addressing periodontal diseases, surgeons often employ the guided tissue regeneration (GTR) technique, which involves the use of a barrier membrane. Aim The aim of the present study is to assess the composition and mechanical strength of chitosan and eggshell membrane.

Lipid and renal profile in assessing the severity of alcoholic liver disease.

Lipid and Renal dysfunction in Alcoholic liver disease (ALD) patients occurs either due to multi-organ involvement or secondary to alcoholism. This study was conducted to evaluate the role of lipid and renal parameters in assessing the severity of progression of ALD. Sixty cases of ALD (two groups based on compensated and decompensated features) and thirty healthy controls for comparison were included.

Prevalence of hs-CRP among Indians with hypertension.

The prevalence of hypertension in the early twentieth century varied in India, ranging from 2-15% in Urban India and 2-8% in Rural India. In the inter heart and inter stroke study, hypertension accounted for 17.9% and 34.

Three-Dimensional Collagen Membranes Challenging the Gold Standard in Gingival Recession.

Gingival recession is a commonly encountered chief complaint in a dental office, most commonly presenting as pain or sensitivity on intake of food or sometimes just seen as an esthetic concern which may present in a localized or generalized form. Such interest toward dental esthetics has encouraged clinicians to formulate newer minimally invasive surgical techniques which are short but still deliver predictable long-term benefits in restoring the patient's smile. One such method was evaluated in the present short communication where a commercially available, biodegradable, and volume-stable collagen membrane was used to manage gingival recession instead of donor grafts.

Suppression of Tumorigenicity 2 Pro-Inflammatory Biomarker Linking Diabetes Mellitus and Periodontitis: A Pilot Study.

BACKGROUND Suppression of tumorigenicity 2 (ST2) is a member of the interleukin (IL)-1 family and has 2 isoforms: ST2L, a transmembrane form, and ST2, a soluble form. IL-33 can act as an immune system alarm signal when released by damaged cells, which in turn activates other cells expressing the ST2 receptor. This can cause inflammatory cytokines to be released and produced, as well as trigger osteoclastogenesis.

Biochemical predictors for Sars-Cov-2 severity.

It is of interest to assess the inflammatory marker profile in SARS-CoV-2 patients and to correlate the levels of systemic inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR), C-Reactive Protein CRP, Ferritin, Creatine kinase (CK), Lactate dehydrogenase (LDH) and liver function analytes total serum proteins, albumin, total bilirubin, direct bilirubin, alkaline phosphatase, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) with the severity of SARS-CoV-2 infections. A total of 1000 COVID-19 positive patient's data were collected. Laboratory assessments consisted of NLR (neutrophil-lymphocyte ratio) by cell counter, C Reactive Protein (CRP) by immunoturbidimetry, Ferritin by electrochemiluminescence (ECLIA) and Creatine Kinase (CK), Lactate Dehydrogenase (LDH), Alkaline phosphatase (ALP), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), Total Bilirubin, Direct Bilirubin, Total Protein and Albumin by spectrophotometry.

Evaluation of alveolar antral anastomosis in south Indian population using cone beam computed tomography: a prospective study.

Objectives: The posterior superior alveolar artery (PSAA) and the infraorbital artery (IOA), both of which are ultimate branches of the maxillary artery, are connected by a horizontal anastomosis. PSAA anastomoses intraosseously and extraosseously with IOA. Profuse bleeding from the lateral wall while performing the direct sinus augmentation is a significant intraoperative complication.

Analgesics/Anti-Inflammatory Drugs Preferred Following Implant Placement: A Retrospective Study.

Background: In dentistry, pain is a rather inevitable perception that often plagues both the care provider and receiver. Pain, which was described by Rene Descartes in the sixteenth century, has been defined as an unpleasant sensory and emotional experience associated with tissue damage or described in terms of such damage. Various dental procedures also provoke a perception of anxiety that culminates with pain and exaggerates the perception of pain.

Impact of COVID-19 on Renal Function: A Multivariate Analysis of Biochemical and Immunological Markers in Patients.

Introduction There have been tremendous continuous efforts to understand the broad spectrum of disease and its sequelae since the start of the coronavirus disease 2019 (COVID-19) pandemic. Several studies have identified biomarkers that correlate with multiple organ failure in COVID-19 patients. The purpose of our study was to evaluate COVID-19-associated kidney injury.

An atypical presentation of plasma cell gingivitis with generalized skin lesions.

This article aims to present a report of an atypical clinical presentation of a plasma cell gingivitis (PCG) case with unusual skin lesions. PCG is a rare benign inflammatory condition which can be classified into Type 4 hypersensitivity reaction. It occurs due to reaction to unknown antigen, often flavoring agents or spices found in chewing gums, toothpastes and lozenges.

Mobility to Stability-Journey of a Hopeless Tooth.

The impact of implant dentistry is such that, today, very few dentists think about saving grade III mobile teeth with recurrent periodontal abscess. This case report presents the management of grade III mobile lower anterior teeth with recurrent periodontal abscess. Treatment included SRP, splinting of the lower anterior teeth using wire and composite, RCT of the lower anterior teeth, periodontal flap surgery, and placement of bone graft and PRF.

Comparative Evaluation of Bone Formation between PRF and Blood Clot Alone as the Sole Sinus-Filling Material in Maxillary Sinus Augmentation with the Implant as a Tent Pole: A Randomized Split-Mouth Study.

The lack of bone volume in the posterior maxillary region can be augmented with sinus elevation. Since the elevated sinus is a closed cavity, a blood clot that fills the sinus space itself can aid in bone formation. The aim of this study was to compare bone formation in the elevated maxillary sinus between platelet-rich fibrin (PRF) and blood clot alone as the sole sinus-filling material with the implant as a tent pole.

Detection of cytomegalovirus, Epstein-Barr virus, and Torque Teno virus in subgingival and atheromatous plaques of cardiac patients with chronic periodontitis.

Background: Periodontitis and atherosclerosis represent a chronic inflammatory process. The incidence of periodontitis in cardiac patients with atherosclerosis is a well-established fact. The role of viruses in the etiopathogenesis of both has been proposed.

Comprehensive rehabilitation using dental implants in generalized aggressive periodontitis.

Generalized aggressive periodontitis (GAP) is a debilitating form of the disease and it results in deteriorating effects on the esthetic and functional aspects of the oral cavity. This case report describes the comprehensive rehabilitation of GAP patient using dental implants. The treatment planning involved thorough scaling and root planning (SRP) with oral hygiene instructions.

Analysis of association of TaqI VDR gene polymorphism with the chronic periodontitis in Dravidian ethnicity.

Aim: The aim of this study is to analyze the association of TaqI vitamin D receptor (VDR) gene polymorphism with the chronic periodontitis (CP) in Dravidian ethnicity.

Materials And Methods: A total of 120 subjects were recruited for this study, which included 60 CP and 60 healthy controls. TaqI VDR gene polymorphism was analyzed using specific primers and amplified by polymerase chain reaction (PCR) and visualized under 2% agarose gel.

Comparative analysis of presence of Cytomegalovirus (CMV) and Epsteinbarr virus -1 (EBV-1) in cases of chronic periodontitis and aggressive periodontitis with controls.

Aim: The aim of the present study was to evaluate the presence of Cytomegalovirus (CMV) and Epsteinbarr virus -1 (EBV-1)viruses in sub gingival plaque of chronic periodontitis (groupA), aggressive periodontitis patients (group B), periodontally healthy controls (group C) and to compare the clinical parameters between virus negative and positive sites in each of these groups.

Materials And Methods: Sixty subjects were included in the study and equally divided into the 3 groups (group A - 20, group B - 20, group C - 20). Sub gingival plaque samples were obtained from the 3 deepest periodontal pocket sites in case of subjects suffering from periodontitis, and from one random bleeding site per quadrant in healthy groups.