Publications by authors named "Ka-Mei Sio"
Fibrinogen-fibrin degradation products (DR-70) are derived from tumor cells or metastases. Our previous study reported the diagnostic values in dogs with tumors, but no research has yet to be conducted to establish DR-70 as a prognostic marker. Herein, we investigated changes in DR-70 concentrations and disease courses in dogs with tumors.
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- Tumor biomarkers are widely used in human medicine, but their effectiveness in veterinary medicine, particularly for dogs, is not well understood, with DR-70 being a potential candidate.
- A study involving 263 dogs with tumors and 60 healthy dogs found that DR-70 concentrations were significantly higher in dogs with tumors, indicating its diagnostic potential.
- The sensitivity and specificity of DR-70 as a tumor biomarker were found to be 84.03% and 78.33%, respectively, but further research with a broader range of canine diseases is needed to confirm its clinical usefulness.
Legumain, a novel asparaginyl endopeptidase, has been observed to be overexpressed in several types of human solid tumors. Elevated levels of legumain are found in human cancers, and this oncoprotein may facilitate tumor invasion and metastasis when overexpressed. These findings suggest that legumain plays a malignant role in cancer biology.
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