Publications by authors named "Ka Yim Chan-Salis"
Article Synopsis
- Researchers discovered that the transcription machinery directly influences topoisomerase 1 (TOP1) activity to manage DNA structure during transcription.
- By using advanced techniques (ChIP-seq and TOP1-seq), they found that TOP1 becomes fully active only after RNA polymerase II releases from its pause during transcription.
- The study highlights the important role of the BRD4 protein in phosphorylating RNA polymerase II, which enhances TOP1's activity and helps alleviate torsional stress during gene expression, potentially leading to new approaches to manipulate gene expression related to diseases.
Erythroid development and differentiation from multiprogenitor cells into red blood cells requires precise transcriptional regulation. Key erythroid transcription factors, GATA1 and TAL1, cooperate, along with other proteins, to regulate many aspects of this process. How GATA1 and TAL1 are juxtaposed along the DNA and their cognate DNA binding site across the mouse genome remains unclear.
View Article and Find Full Text PDFWe previously reported that a pan-PAD inhibitor, YW3-56, activates p53 target genes to inhibit cancer growth. However, the p53-independent anticancer activity and molecular mechanisms of YW3-56 remain largely elusive. Here, gene expression analyses found that ATF4 target genes involved in endoplasmic reticulum (ER) stress response were activated by YW3-56.
View Article and Find Full Text PDFTumor suppressor p53 regulates transcription of stress-response genes. Many p53 targets remain undiscovered because of uncertainty as to where p53 binds in the genome and the fact that few genes reside near p53-bound recognition elements (REs). Using chromatin immunoprecipitation followed by exonuclease treatment (ChIP-exo), we associated p53 with 2,183 unsplit REs.
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