Kidney transplant candidates' perspectives on the implementation of a Canadian Willingness to Cross program: A strategy to increase access to kidney transplantation for highly sensitized patients.

Background: Kidney transplantation is the optimal treatment for end-stage renal disease. However, highly sensitized patients (HSPs) have reduced access to transplantation, leading to increased morbidity and mortality on the waiting list. The Canadian Willingness to Cross (WTC) program proposes allowing transplantation across preformed donor specific antibodies (DSA) determined to be at a low risk of rejection under the adaptive design framework.

Diverse residues of intracellular loop 5 of the Na/H exchanger modulate proton sensing, expression, activity and targeting.

The mammalian Na/H exchanger isoform 1 (NHE1) is an integral membrane protein that regulates intracellular pH (pH) by removing a single intracellular proton in exchange for one extracellular sodium ion. It is involved in cardiac hypertrophy and ischemia reperfusion damage to the heart and elevation of its activity is a trigger for breast cancer metastasis. NHE1 has an extensive 500 amino acid N-terminal membrane domain that mediates transport and consists of 12 transmembrane segments connected by intracellular and extracellular loops.

Sequential and controlled release of small molecules from poly(N-isopropylacrylamide) microgel-based reservoir devices.

Systems composed of a poly(N-isopropylacrylamide)-co-acrylic acid (pNIPAm-co-AAc) microgels (AAc-MG) and poly(N-isopropylacrylamide-3-(acrylamido)phenylboronic acid) (pNIPAm-co-APBA) microgels (APBA-MG) were used to sequentially release small molecules to a system in a controlled and triggered fashion. Specifically, at pH 10.0, methylene blue (MB, positively charged) exhibited strong electrostatic interactions with both the negatively charged AAc and APBA-modified microgels.