Publications by authors named "Ka Nin Wong"
Purpose: The aim of this study was to establish an algorithm for the prescription of Y glass microsphere radioembolization (Y-GMRE) of HCC in individual patients based on the relationship between tumour dose (TD) and response validated by Y PET/CT dosimetry and dual-tracer PET/CT metabolic parameters.
Methods: The study group comprised 62 HCC patients prospectively recruited for Y-GMRE who underwent pretreatment dual-tracer (C-acetate and F-FDG) PET/CT as surrogate markers of HCC cellular differentiation. Pretreatment tumour-to-nontumour ratio on Tc-MAA SPECT/CT (T/NT) was correlated with posttreatment Y PET/CT T/NT after quantification validation.
A bedridden 90-year-old man with fever and elevated prostate-specific antigen (PSA) (49 ng/mL) was referred for differentiation between infection and tumor. F-FDG PET/CT was negative for infection, but Ga-PSMA PET/CT showed multiple lesions in prostate gland with infiltration to bladder wall and seminal vesicle, consistent with locally advanced prostate cancer. The lesion with the highest Ga-PSMA uptake was strongly avid for Ga-DOTATOC, suggesting neuroendocrine tumor differentiation.
View Article and Find Full Text PDFHepatoblastoma is the most common primary liver cancer in the pediatric population. Disease relapse might be occult and difficult to detect. C-acetate positron emission tomography has been applied in patients with hepatocellular carcinoma due to the insensitivity of fluorodeoxyglucose, but data on hepatoblastoma patients have been scarce.
View Article and Find Full Text PDFUnlabelled: We prospectively compared (11)C-acetate with (18)F-FDG in a PET/CT evaluation of multiple myeloma (MM), specifically on diagnostic accuracy, identification of high-risk patients, and monitoring of treatment response.
Methods: Dual-tracer PET/CT was performed on 35 pathologically and clinically confirmed and untreated patients (26 with symptomatic MM, 5 with smoldering MM, and 4 with monoclonal gammopathy of unknown significance) and 20 individuals with normal marrow.
Results: (11)C-acetate showed significant incremental value over (18)F-FDG (84.
Outcome of hepatobiliary scanning: preterm versus full-term cholestatic infants.
J Paediatr Child Health
January 2013
Objectives: The aims of this study were to evaluate the specificity of a non-draining hepatobiliary scintigraphy (HBS) for biliary atresia (BA) in preterm and full-term babies, to verify the relationship between non-draining scan and higher levels of direct bilirubin and to find an objective criterion to guide the time in performing HBS.
Methods: A total of 175 infants (113 males and 62 females, median age of 45 days) with 181 HBS performed in Tuen Mun Hospital between January 1998 and May 2010 were retrospectively analysed. A 'non-draining' scan was defined as one showing no excretion of radiolabelled tracer into the small bowel 24 h after injection.
Unlabelled: We studied the metabolic characteristics of RCC subtypes and angiomyolipoma with 18F-FDG and 11C-acetate PET/CT.
Methods: Fifty-eight patients with both baseline CT and dual-tracer PET/CT were recruited: 10 angiomyolipoma (16 lesions) and 48 RCC (50 lesions). Each lesion was assessed for SUVmax ratio (lesion-to-normal kidney) on 11C-acetate/18F-FDG PET and attenuation density on CT.
A 9-year-old girl with clinical suspicion of renovascular hypertension was referred for captopril renography. This showed a segmental abnormality when the left kidney was analyzed as two separate cortical regions of interest. Subsequent angiography confirmed stenosis in the distal mid and lower pole branches of the left renal artery.
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