Inhibition of Glutamate-to-Glutathione Flux Promotes Tumor Antigen Presentation in Colorectal Cancer Cells.

Colorectal cancer (CRC) cells display remarkable adaptability, orchestrating metabolic changes that confer growth advantages, pro-tumor microenvironment, and therapeutic resistance. One such metabolic change occurs in glutamine metabolism. Colorectal tumors with high glutaminase (GLS) expression exhibited reduced T cell infiltration and cytotoxicity, leading to poor clinical outcomes.

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation.

One of the primary mechanisms of tumor cell immune evasion is the loss of antigenicity, which arises due to lack of immunogenic tumor antigens as well as dysregulation of the antigen processing machinery. In a screen for small-molecule compounds from herbal medicine that potentiate T cell-mediated cytotoxicity, we identified atractylenolide I (ATT-I), which substantially promotes tumor antigen presentation of both human and mouse colorectal cancer (CRC) cells and thereby enhances the cytotoxic response of CD8+ T cells. Cellular thermal shift assay (CETSA) with multiplexed quantitative mass spectrometry identified the proteasome 26S subunit non-ATPase 4 (PSMD4), an essential component of the immunoproteasome complex, as a primary target protein of ATT-I.

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation.

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost CD8+ T cell-mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of tumor-specific antigens via T cell receptors.

ST2 as checkpoint target for colorectal cancer immunotherapy.

Immune checkpoint blockade immunotherapy delivers promising clinical results in colorectal cancer (CRC). However, only a fraction of cancer patients develop durable responses. The tumor microenvironment (TME) negatively impacts tumor immunity and subsequently clinical outcomes.

Perceptions of older people among Chinese adolescents: conceptual and methodological issues.

Ageism against older people exists worldwide almost among all age groups and adolescents are of no exception. Numerous studies with specific reference to adolescents of different age, gender, educational level, socioeconomic background, knowledge about aging and experiences with older people showed that they had different perceptions of and attitudes toward older people, but such findings are not entirely conclusive. The situation of Hong Kong is even more confused as there are few studies examining this topic.

Elder lifelong learning, intergenerational solidarity and positive youth development: the case of Hong Kong.

Elder lifelong learning has been promoted worldwide under different modes for upgrading quality of life of elders and actualizing successful aging. With multiple objectives, some modes of the elder lifelong learning program attempt to simultaneously address the social issues of age-segregation and negative perceptions of older people by adopting an intergenerational approach. Such an approach links the two non-biological generations--the young and the old--together purposefully for nurturing intergenerational solidarity and integration.