[Formation of Enterobacter cloacae resistance to disinfectants under the effect of bactericidal concentrations of quaternry ammonium compounds in the experiment].

Aim: Study the possibility of formation of induced resistance of purulent-septic infection (PSI) causative agents against disinfectants (DI) in bactericidal concentrations.

Materials And Methods: Daily exposure to bactericidal concentrations of preparations from the group of quaternary ammonium compounds (QAC) on Enterobacter cloacae strain that has incomplete sensitivity to the same disinfectants on the same test objects was carried out in experiments on test objects from wood and plastic. Exposure was carried out until the moment of transition from incomplete sensitivity to resistance.

[Sensitivity of nosocomial purulent-septic infection causative agents to disinfection agents and antibiotics].

Aim: Study the sensitivity of nosocomial purulent-septic infection (PSI) causative agents to disinfectants (DA) and antibiotics (AB).

Materials And Methods: Sensitivity to DA and AB of 209 PSI causative agent strains isolated from patients and the environment of 2 obstetric and 3 surgical hospitals was studied in 2009-2011. Sensitivity to DA of 94 strains and to AB of 189 strains of Pseudomonas aeruginosa isolated from patients with signs of PSI of reanimation and intensive therapy and surgical departments of a multi-field hospital was studied in 2012.

[Morphologic and functional heterogeneous changes of the urinary bladder different parts at rats with infravesical obstruction of the urinary tracts].

Infravesical obstruction of the lower urinary tracts of 30 rats was carried out by the measured constriction of the urethral prevesical parts. Morphologic and functional changes of the urinary bladder different parts were studied in 1 week and in 3 months. Compensatory hypertrophy of the detrusor was accompanied increasing of hypertrophied, atrophic and native forms of leiomyocytes, as so their transformation into myofibroblasts with connective tissue formation between the muscle fibers mainly in the neck of urinary bladder Contractility of the detrusor decreased with their tonus increasing mainly in the neck of urinary bladder too.

[Calixarenes: effects on energy exchange in plant tissues].

The distinctive features of the influence of synthetic compounds of a new class, calixarenes, on the energy exchange of the plant tissues and on the ionic permeability of the plant membranes were investigated. Calixarenes of the different chemical structure were shown to sufficiently influence the oxygen consumption by wheat roots, pH of the incubation mixture, and the potassium ions release. Aminomethylated calyx[4]resorcinaren showed the highest effect.

Ecosystem and human health assessment to define environmental management strategies: The case of long-term human impacts on an Arctic lake.

There are rich deposits of mineral and fossil natural resources in the Arctic, which make this region very attractive for extracting industries. Their operations have immediate and vast consequences for ecological systems, which are particularly vulnerable in this region. We are developing a management strategy for Arctic watersheds impacted by industrial production.

[Comparative genome analysis of Helicobacter pylori strains].

DNA macroarrays were used to characterize 17 Helicobacter pylori strains isolated in four geographic regions of Russia (Moscow, St. Petersburg, Kazan, and Novosibirsk). Of all genes, 1272 (81%) proved to occur in all strains and to constitute a functional core of the genome, and 293 (18.

[Colonic microenvironment in familial helicobacter infection].

To elucidate the significance of the familial microenvironment in the genesis of Helicobacter infection, a clinical and instrumental investigation was made of 13 families selected by the probands who had digestive diseases associated with H. pylori: gastroduodenitis and duodenal ulcer disease. The occurrence of Helicobacter infection and gastritis in the family members was ascertained to be largely determined by their concurrent residence in the limited area, i.

[New cases of helicobacter pylori associated duodenal ulcer].

Aim: Generalization of the results obtained through analysis of examinations of new cases of duodenal ulcer (DU) with patients suffering from DU of different duration, made in two main aspects: the patients' Helicobacter pylori (HP) status determined by histological, bacteriological, immunological studies and rapid urease test and their clinical manifestations, including analysis of risk factors predisposing to peptic ulcer.

Materials And Methods: Two groups of patients with DU: 1) 23 new cases; 2) (a group of comparison) 43 patients with DU of different duration were examined. Family history, risk factors (smoking, alcohol consumption, use of nonsteroidal antiinflammatory agents), concurrent diseases were analyzed.

[Disease characteristics of the population on the territory of the city of Kirovo-Chepetsk].

Medical and ecologic evaluation of ecologic situation in Kirovo-Tchepetsk (Kirov region) included study of morbidity in the town and referent territories. Levels and dynamics of morbidity, prevalence, number of pathologic processes in children and other parameters could characterize the town as an ecologically unfavorable territory.

[Mortality and disablement as criteria in the evaluation of ecological situation].

A uniform study analyzed criteria for evaluation of ecologic jeopardy of some territories. Mortality and disablement appeared to be inadequate for that evaluation. The authors suggest specific parameters for cities neighbouring to major chemical enterprises.

[Dynamics of iron metabolism in patients with homozygotic beta-thalassemia after splenectomy].

Iron metabolism was followed up in patients with homozygotic beta-thalassemia after 6 to 18 months, 2-3 years, and 4 to 12 years after splenectomy. Iron reserves of the body were found gradually increasing with time, this being expressed in very high values of serum and red cell ferritins and serum iron. Noteworthy is also an increase of circulating immune complex levels and appearance of a "free" pool of iron.

[The detection of the Shiga toxin antigen in connection with other virulence factors--the O and K antigens of enterobacteria].

The results of the detection of Shiga toxin antigen in culture filtrates of 73 enterobacterial strains by the methods of countercurrent electrophoresis and coagglutination, as well as their correlation with the presence of other factors of virulence, O- and K-antigens, have been analyzed. Sharply pronounced inverse correlation between the capacity of enterobacteria to synthesize Shiga (Shiga-like) toxins and their capacity to synthesize acidic polysaccharide surface-specific K- (Vi-) antigens has been established.

[A comparative evaluation of the glycogen content in the peripheral blood of normal cattle and in chronic lymphoid leukemia].

Peripheral blood lymphocytes in cows of four groups (healthy, exposed to leucosis, those affected by leucosis at early or at developed stages) were tested for their glycogen contents by the two following methods: the semiquantitative PAS technique (Shabadash, 1947) and the quantitative cytofluorimetric variant of PAS reaction in the M. V. Kudriavtseva modification (1970).

[Electron microscopic study of the interaction of virulent and avirulent Shigella flexneri strains with the macrophages of murine peritoneal exudate].

The electron microscopic dynamic study of the interaction of S. flexneri virulent strain 2a and S. flexneri avirulent strain, genetically related to strain 2a and having the same antigenic structure, with peritoneal macrophages of CBA mice at an early period showed differences in the cytotoxic action of these strains.