New cytotoxic spatane diterpenoids from marine alga Stoechospermum marginatum.

Three new spatane diterpenoids (1-3) were isolated from the brown alga Stoechospermum marginatum together with three known compounds (4-6). The structures of these compounds were determined by the detailed NMR spectroscopic and Mass spectrometric analyses. All the isolated compounds were screened for their cytotoxic potentials against a panel of four human cancer cell lines, which include DU145 (Prostate), B16F10 (Melanoma), MDA MB-231 (Breast), and HeLa (Cervical) along with a normal cell line (HEK).

Bioactive constituents from Tinospora cordifolia (willd.): Isolation, synthesis and their immunomodulatory activity.

Traditional medicinal plants have been used for centuries for their immunomodulatory properties and therapeutic potentials. The present study aims to investigate the immunomodulatory constituents from traditional medicinal plant, Tinospora cordifolia (willd.).

Radical species generating technologies for decontamination of species in food: a recent review report.

Foodborne illnesses occur due to the contamination of fresh, frozen, or processed food products by some pathogens. Among several pathogens responsible for the illnesses, is one of the lethal bacteria that endangers public health. Several preexisting and novel technologies, especially non-thermal technologies are being studied for their antimicrobial effects, particularly toward .

A translation proofreader of archaeal origin imparts multi-aldehyde stress tolerance to land plants.

Aldehydes, being an integral part of carbon metabolism, energy generation, and signalling pathways, are ingrained in plant physiology. Land plants have developed intricate metabolic pathways which involve production of reactive aldehydes and its detoxification to survive harsh terrestrial environments. Here, we show that physiologically produced aldehydes, i.

Nanotechnological synergy of mangiferin and curcumin in modulating PI3K/Akt/mTOR pathway: a novel front in ovarian cancer precision therapeutics.

Ovarian cancer, colloquially termed the "silent killer" among gynecological malignancies, remains elusive due to its often-asymptomatic progression and diagnostic challenges. Central to its pathogenesis is the overactive PI3K/Akt/mTOR signaling pathway, responsible for various cellular functions, from proliferation to survival. Within this context, the phytochemical compounds mangiferin (derived from ) and curcumin (from ) stand out for their potential modulatory effects.

Distinct localization of chiral proofreaders resolves organellar translation conflict in plants.

Plants have two endosymbiotic organelles originated from two bacterial ancestors. The transition from an independent bacterium to a successful organelle would have required extensive rewiring of biochemical networks for its integration with archaeal host. Here, using as a model system, we show that plant D-aminoacyl-tRNA deacylase 1 (DTD1), of bacterial origin, is detrimental to organellar protein synthesis owing to its changed tRNA recognition code.

Influence of Bulk Nanobubbles Generated by Acoustic Cavitation on Powder Microstructure and Rehydration Characteristics of Spray-Dried Milk Protein Concentrate Powders.

Bulk nanobubbles (BNBs) have widespread applications in various fields of science due to numerous peculiar characteristics. Despite significant applications, only limited investigations are available on the application of BNBs in food processing. In the present study, a continuous acoustic cavitation technique was used to generate bulk nanobubbles (BNBs).

Valorization of Fruit Waste for Bioactive Compounds and Their Applications in the Food Industry.

The fruit production and processing sectors produce tremendous amounts of by-products and waste that cause significant economic losses and an undesirable impact on the environment. The effective utilization of these fruit wastes can help to reduce the carbon footprint and greenhouse gas emissions, thereby achieving sustainable development goals. These by-products contain a variety of bioactive compounds, such as dietary fiber, flavonoids, phenolic compounds, antioxidants, polysaccharides, and several other health-promoting nutrients and phytochemicals.

Synthesis of novel thiazoles bearing lupeol derivatives as potent anticancer and anti-inflammatory agents.

Lupeol is one of the most important metabolite in the class of terpenoids and possess excellent anticancer, anti-inflammatory, anti-diabetic activities etc. In the present study, the different thiazoles and oxazoles bearing lupeol derivatives were prepared to enhance their biological activity. Initially, the cytotoxic activity results showed that the synthesized lupeol derivatives ( and ) showed significant activity against various cancer cells and the compounds and exhibited excellent activity against CAL27 cells.

Influence of micro- and nano-bubble treatment on morphological characteristics and flow properties of spray-dried milk protein concentrate powders.

This study investigated the morphological and bulk handling properties of milk protein concentrate (MPC) powders manufactured from incorporating micro- and nano-bubbles (MNB) before spray drying. Control MPC powders (C-MPC; no MNB treatment) and MNB-treated MPC powders (MNB-MPC; MPC dispersions passed through the MNB system and subsequently spray dried) were characterized in terms of particle size, shape factors, stability, variable flow rate, shear cell tests, compressibility, and wall friction. The MPC powders produced after the MNB injection process had better flowability and lower basic flow energy.

Comprehensive Lichenometabolomic Exploration of Vain Using UPLC-Q-ToF-MS/MS: An Identification of Free Radical Scavenging and Anti-Hyperglycemic Constituents.

In this study, we propose ultra-performance liquid chromatography coupled with quadrupole/time-of-flight mass spectrometry (UPLC-QToF-MS/MS)-guided metabolite isolation as a choice analytical approach to the ongoing structure−activity investigations of chemical isolates from the edible lichen, Ramalina conduplicans Vain. This strategy led to the isolation and identification of a new depside (5) along with 13 known compounds (1−4, 6−14), most of which being newly described in this lichen species. The structures of the isolates were established by detailed analysis of their spectral data (IR, NMR, and Mass).

Postbiotics: Current Trends in Food and Pharmaceutical Industry.

Postbiotics are non-viable bacterial products or metabolic byproducts produced by probiotic microorganisms that have biologic activity in the host. Postbiotics are functional bioactive compounds, generated in a matrix during anaerobic fermentation of organic nutrients like prebiotics, for the generation of energy in the form of adenosine triphosphate. The byproducts of this metabolic sequence are called postbiotics, these are low molecular weight soluble compounds either secreted by live microflora or released after microbial cell lysis.

Correlating W-Boson Mass Shift with Muon g-2 in the Two Higgs Doublet Model.

We show an interesting correlation between the recent high precision measurement of the W-boson mass by the CDF Collaboration and the muon (g-2) anomaly in the context of the two Higgs doublet model. One-loop diagrams involving the exchange of neutral scalar bosons can explain the muon (g-2), which, however, requires significant mass splittings among members of the second Higgs doublet. These splittings also generate a positive shift in the mass of the W boson, consistent with the recent CDF measurement.

Marine Based Natural Products: Exploring the Recent Developments in the Identification of Antimicrobial Agents.

The marine ecosystem is the less explored, biologically diverse, and vastest resource to discover novel antimicrobial agents. In recent decades' antimicrobial drugs are losing their effectiveness due to the growing resistance among pathogens, which causes diseases to have considerable death rates across the globe. Therefore, there is a need for the discovery of new antibacterials that can reach the market.

Convolutional neural network based CT scan classification method for COVID-19 test validation.

Given the novel corona virus discovered in Wuhan, China, in December 2019, due to the high false-negative rate of RT-PCR and the time-consuming to obtain the results, research has proved that computed tomography (CT) has become an auxiliary One of the essential means of diagnosis and treatment of new corona virus pneumonia. Since few COVID-19 CT datasets are currently available, it is proposed to use conditional generative adversarial networks to enhance data to obtain CT datasets with more samples to reduce the risk of over fitting. In addition, a BIN residual block-based method is proposed.

Light Weighted Healthcare CNN Model to Detect Prostate Cancer on Multiparametric MRI.

The SEMRCNN model is proposed for autonomously extracting prostate cancer locations from regions of multiparametric magnetic resonance imaging (MP-MRI). Feature maps are explored in order to provide fine segmentation based on the candidate regions. Two parallel convolutional networks retrieve these maps of apparent diffusion coefficient (ADC) and T2W images, which are then integrated to use the complimentary information in MP-MRI.

Supervised Computer-Aided Diagnosis (CAD) Methods for Classifying Alzheimer's Disease-Based Neurodegenerative Disorders.

Alzheimer's disease is incurable at the moment. If it can be appropriately diagnosed, the correct treatment can postpone the patient's illness. To aid in the diagnosis of Alzheimer's disease and to minimize the time and expense associated with manual diagnosis, a machine learning technique is employed, and a transfer learning method based on 3D MRI data is proposed.

Facet-Dependent Bactericidal Activity of AgPO Nanostructures against Gram-Positive/Negative Bacteria.

AgPO nanostructures (APNs) containing silver (Ag metal; of the noble metal families) have the potential to exhibit enzyme-mimetic activity. A nanostructure shape, including its surface facets, can improve the bioactivity of enzyme mimicry, yet the molecular mechanisms remain unclear. Herein, we report facet-dependent peroxidase and oxidase-like activity of APNs with both antibacterial and biofilm degrading properties through the generation of reactive oxygen species.

Generation methods, stability, detection techniques, and applications of bulk nanobubbles in agro-food industries: a review and future perspective.

Nanobubble (NB) technologies have received considerable attention for various applications due to their low cost, eco-friendliness, scale-up potential, process control, and unique physical characteristics. NB stands for nanoscopic gaseous cavities, typically <1 μm in diameter. NBs can exist on surfaces (surface or interfacial NBs) and be dispersed in a bulk liquid phase (bulk NBs).

Improved Capsule Network Optimization Hierarchical Convolution Algorithm for Mental Health Recognition.

To address the shortcomings of standard convolutional neural networks (CNNs), the model structure is complex, the training period is lengthy, and the data processing technique is single. A modified capsule network is presented to optimize hierarchical convolution-the algorithm for identifying mental health conditions. To begin, two types of data processing are performed on the original vibration data: wavelet noise reduction and wavelet packet noise reduction; this retains more valuable information for mental health identification in the original signal; secondly, the CNN employs the concept of hierarchical convolution, and three distinct scaled convolution kernels are utilized to extract features from numerous angles; ultimately, the convolution kernel's extracted features are fed into the pruning strategy's capsule network for mental health diagnosis.

Synthesis and antiproliferative activities of novel piscidinol a derivatives as potential anticancer agents.

Piscidinol A (), a major compound isolated from , showed modest anticancer activity against cancer cell lines. Subsequently, a series of analogues were synthesised by modification of the key structural functionalities of this high yield natural product and assessed for their anticancer potential against various cancer cell lines. Among the tested derivatives, the compounds and are significantly reduced the cell viability at 5.

Application of micro- and nano-bubbles in spray drying of milk protein concentrates.

Micro- and nano-bubbles (MNB) have unique properties and have attracted great attention in the past 2 decades, offering prospective applications in various disciplines. The first objective of this study was to investigate whether venturi-style MNB generation is capable of producing sufficient bulk MNB. A nanoparticle tracking system was used to measure the bubble concentration and particle size of MNB-treated deionized water.