[The role of adipose tissue in rheumatoid arthritis].

Aim: To estimate the frequency of obesity in a Russian cohort of patients with early rheumatoid arthritis (RA), determine adipocytokine (adiponectin, leptin) levels and their relation to RA activity.

Materials And Methods: 47 patients with early RA fulfilling ACR/EULAR(2010) criteria and using no BAID or GC. Mean age 57 [47;62] yr, duration of disease 7 [4;8] yr, median of DAS28 5.

[The infection of ixodid ticks collected from humans with the tick-borne encephalitis virus in Tomsk city and its suburbs].

The ticks Ixodes persulcatus and I. pavlovskyi collected from people visited gardens and suburban forests have been examined by the IFA methods on the presence of tick-borne encephalitis virus (TEV). It was established, that the most part of ticks collected from humans belongs to I.

[Recurrent thromboses and hemorrhagic complications in patients with antiphospholipid syndrome during therapy with warfarin plus aspirin].

Aim: To estimate the frequency of relapses of thrombotic and hemorrhagic complications during moderately intensive therapy for antiphospholipid syndrome (APS) with warfarin with and without aspirin.

Subjects And Methods: Eighty-two patients diagnosed as having the antiphospholipid syndrome were examined. Group 1 patients (n = 49) received warfarin alone as an antithrombotic drug; Group 2 patients (n = 33) had a combination therapy with warfarin plus aspirin.

[Warfarin in the treatment of antiphospholipid syndrome].

Aim: To assess efficacy and safety of warfarin therapy and its combination with low-dose acetylsalicylic acid (ASA) in antiphospholipid syndrome (APS).

Material And Methods: The trial enrolled 60 APS patients. They were divided into two groups: group 1 (n = 39) on antithrombotic therapy with warfarin; group 2 (n = 21) on combined therapy with warfarin and ASA.

[Seasonal change in the hygienic indices of the quality of fishes from the Amur River].

The paper is the first to present the results of a comprehensive assessment of the seasonal changes in the hygienic indices of the quality of newly caught fishes from the Amur River. Microbiological analysis of their flesh tissues and gills and physicochemical studies has been used as basic techniques for the determination of some classes of volatile substances (nitrocompounds, histamine, trimethylamine, aldehydes, alcohols, ketones, etc.).

[A new rapid method for indication of tick-borne encephalitis viral antigen].

A coagglutinizing reagent has been designed, which makes it possible to make a rapid diagnosis of tick-borne encephalitis in the coagglutination test within 2-5 minutes. Laboratory tests of the agent have shown that the coagglutination test is sensitive and specific (it is many times more sensitive than indirect hemagglutination test and 2-4 times more sensitive than enzyme immunoassay). The trials conducted on natural and clinical materials also have confirmed the sensitivity and specificity of this method.

[Preparation and regeneration of protoplasts from Bacillus megaterium cells dried by sublimation].

Bacterial protoplasts are widely used in genetical research, for instance, in protoplasts fusion experiments and the transfer of heterologous DNA into bacterial cells. The usage of a new fresh grown culture of bacteria in every experiment restricts the reproducibility of the results preventing the technique becoming widespread. The use of antioxidants as components of stabilizing medium for sublimation drying of Bacillus megaterium cells supported cellular viability in bacterial culture.

[Oxidative damage to E. coli membranes caused by superoxide radicals].

The effects of bacterial membranes of active oxygen species photochemically generated by riboflavin-histidine systems were studied. According to SDS-PAAG data, the formation of high molecular weight protein aggregates and the appearance of fluorochromes whose fluorescence is seen in the longwave length region of the spectrum (lambda excit = 350 nm, lambda emis = 400-500 nm) and which are bound to the proteins, are suggestive of membrane oxidation consisting in the chemical modification of protein components. The presence in E.

[Opisthorchiasis in Chernigov Province (the situation and control and prevention measures)].

The results of planned population surveys for opisthorchiasis performed by teams of epidemiologists in 11 districts of Chernigov Province have been reviewed. 130,067 individuals in 156 communities have been examined. All the communities were situated not more than 5 km from the main water artery of the area--the Desna River and its main tributaries--the Seim, the Ubed', the Doch', the Borzna.

[The effect of hypothermia on the structural-functional properties of erythrocyte membranes in albino rats].

Under conditions of hypothermia intensification of lipid peroxidation, activation of phospholipase A2 and distinct alteration in lipid metabolism were found in rat erythrocyte membranes. Alterations in membrane composition correlated with a decrease in erythrocyte resistance and their stability to deformation. Erythrocytes with altered structure-functional properties might be responsible for hemodynamic impairments of tissues.

[Listeria antigens and their isolated protein fractions].

Antigens have been obtained from standard Listeria strains 1 and 4a by alcohol precipitation, sonication and multiple freezing and thawing. From these antigens protein fractions, immunologically identical as shown by the precipitation test and immunoelectrophoresis and similar in their chemical composition, have been isolated. The immunogenic properties of the fractions are determined by the polysaccharide-protein complex represented by amino acids (proline, histidine, lysine) and monosaccharides (ribose, glucose, arabinose), common for the fractions of three antigens.

[Optimization of treatment of patients with insulin-dependent diabetes mellitus using multiple injections of insulin].

The use of various regimens of multiple insulin injections versus the regimen of a single injection resulted in more stable compensation of diabetes mellitus (glycemia stabilization), a decrease in insulin demand, smoothing over circadian glycemic variations, and correction of hypoglycemia. A choice of the number of injections and the time of administration depended on the type of a diabetic course, individual features of the patient's life style and work.

[Succinate dehydrogenase activity of Escherichia coli cells after heat stress and during the reparative process].

The resting cells of different E. coli cells remained viable after their heating at 48 degrees C for 30 min. The activity of their succinate dehydrogenase (SDH) (EC 1.

[Function of the hypothalamo-hypophyseal-thyroid system in juvenile enlargement of the thyroid].

A study of TTH, T3 and T4 content in the blood serum of adolescents with juvenile thyroid enlargement showed changes which were typical of subclinical hypothyrosis. A conclusion is made about the necessity of a follow-up of children with juvenile thyroid enlargement and administration of pathogenetic therapy with thyroid hormonal drugs.

[Diagnostic problems of autoimmune thyroiditis].

The most informative diagnostic criteria of autoimmune thyroiditis were revealed. A kit of diagnostic tests were offered for each version of autoimmune thyroiditis. The lowest percentage of antibodies against thyroglobulin was demonstrated for the hyperthyroid hypertrophic version of autoimmune thyroiditis, while the highest for its atrophic pattern.