Concepts of good mental health and wellbeing in people with intellectual disability: Study protocol for a systematic review.

Introduction: Good mental health is an indispensable aspect of good general health and different definitions of good mental health have been developed for the general population. However, it is not clear how these definitions can be applied to people with intellectual disabilities (ID), as they may have difficulties in many facets encompassed in existing definitions. Yet, people with ID can be mentally healthy or mentally ill just as people without ID.

Informant-based assessment instruments for dementia in people with intellectual disability: A systematic review and standardised evaluation.

Background: Dementia in people with intellectual disability (ID) is frequent but hard to recognise. Evidence-based recommendations for suitable instruments are lacking.

Aims: The present study set out to evaluate informant-based dementia assessment instruments and to provide evidence-based recommendations for instruments most suitable in clinical practice and research.

Satisfaction with life in Special Olympic athletes: the role of autonomy support and basic need fulfilment.

Athletes in the general population report higher satisfaction of basic needs when coaches are providing an autonomy supportive sport climate (ASSC). Our study aims at investigating whether ASSC is associated with satisfaction with life in athletes with intellectual disabilities (ID) and whether this association is mediated by basic need satisfaction. During the Special Olympics World Winter Games 2017, 168 athletes with ID ( = 33.

Informant-based assessment instruments for dementia and their measurement properties in persons with intellectual disability: systematic review protocol.

Introduction: Persons with intellectual disability (ID) are at a higher risk of developing dementia than persons without ID, with an expected earlier onset. Assessment methods for the general population cannot be applied for persons with ID due to their pre-existing intellectual and functional impairments. As there is no agreed-upon measure to assess dementia in persons with ID, multiple instruments for this purpose have been developed and adapted in the past decades.

Results of selfmonitoring on glucometer systems Advance and Optium in daily routine.

The aim of this prospective clinical study was to compare the results of B-glucose estimations performed simultaneously on glucometer Advance (with Micro-draw strips) and Optium (G3 strips) by lay healthy volunteers under non-standardized conditions of everyday life, to assess the difficulties dealing with lay-handling of these systems and to demonstrate the possibilities of the software Glucobalance (Hypoguard) and PC-Link (Medisense/Abbott) for the analysis of selfmonitoring. In the course of 5 days, a total of 721 pairs of measurements were carried out on 10 pairs of glucometer Advance and Optium by 10 healthy volunteers aged 16-40 years. The data transfer of all values into computer from glucometer Advance using the Glucobalance software and from glucometer Optium using the PC-Link was carried out to determine the results.

Contribution to the coincidence of malignant tumours and some allergic manifestations.

Clinical observations during the past decades led us to the early empirical assumptions that adult patients affected by certain types of allergic manifestations may have a lower prevalence of malignant tumors. In order to test those observations as well as some contradictory reports (1-3), we conducted a retrospective study using 32 years of records and statistics of a medium-sized hospital (420 beds) at St. Mary's Hospital, a general, non-chronic, teaching hospital, affiliated with McGill University in Montreal.

[Importance of determination of serum beta-2-microglobulin levels in patients with Hodgkin's lymphoma].

The authors evaluated retrospectively in a group of 69 adult patients with Hodgkin's lymphoma the relationship between the beta-2-microglobulin serum level, basic demographic parameters (age, sex) and factors characterizing the extent (stage III and IV, "bulk" or mediastinal mass, number of affected areas of lymph nodes) and activity of the tumour (presence of B-symptoms, red cell sedimentation rate, haemoglobin, albumin and lactate dehydrogenase level, number of leucocytes and lymphocytes). They analyzed also the possible prognostic impact of beta-2-microglobulin on the therapeutic response risk of relapse and patient's survival. Methods of univariant statistical analysis confirmed the correlation of beta-2-microglobulin level with all investigated metric parameters of patients (advanced age, number of affected nodes, red cell sedimentation rate and lactate dehydrogenase level, lower albumin, haemoglobin level, numbers of leucocytes and lymphocytes).

Prognostic factors in astrocytomas: relationship of p53, MDM-2, BCL-2 and PCNA immunohistochemical expression to tumor grade and overall patient survival.

The immunohistochemically detected expression of p53, BCL-2, MDM-2 and PCNA proteins in samples of tumor tissues of 42 patients with astrocytomas or glioblastoma multiforme was statistically compared to degree of malignancy and overall survival. We found relation between p53 protein expression and survival in the high grade astrocytomas group (more cases of p53 immunonegative tumors with longer survival), and significantly higher BCL-2 protein expression as well as significantly higher MDM-2 protein expression in the group of low grade astrocytomas. PCNA protein expression showed any relation to tumor grade or survival.

[Interferon-alpha in the treatment of patients with chronic myeloid leukemia].

A retrospective analysis of the treatment with Interferon alpha in 18 patients with Ph positive chronic myeloid leukaemia is presented and compared with the results of peroral chemotherapy with Hydroxyurea or Busulphan in 20 patients. Patients treated with Interferon were significantly younger than the control group (median age 40.5 versus 55.

Expression of p53 in glioblastoma multiforme cells: relationship to survival, proliferation and glycosylation.

Immunohistochemically assessed p53 expression was correlated with overall survival in 20 patients with glioblastoma multiforme. Various epitopes of p53 molecule were detected using DO-1, DO-7, CM-1 and BP-12-53 antibodies, proliferative activity was estimated using anti-PCNA and anti-Ki-67 antibodies and assessment of glycosylation changes using lectin histochemistry completed the study. The results show a statistically significant correlation between DO-1 binding and survival.

The spring-fall variations in the prevalence of environmental mycobacteria in drinking water supply system.

The fluctuation in the prevalence of environmental mycobacteria in relation to nutritional conditions in nature was repeatedly described in literature. The seasonal difference in potable water supply system has not yet been documented. Potable water samples from water supply systems of 16 localities were analyzed.

Seasonal variations in the occurrence of environmental mycobacteria in potable water.

A fluctuation in the prevalence of environmental mycobacteria in relation to nutritional conditions in nature has been repeatedly described in the literature. A seasonal difference in the potable water supply system has not yet been documented. Potable water samples from the supply systems of 16 identical localities were analyzed.

Chest diameters in the body mass forecast.

Two other body mass indices have been studied in the paper, by means of which the density is to measure human body has on the surface and in the volume of the hypothetic cylinder with the height equal to that of stature and with the circumference computed from the transverse and sagittal diameters of the chest. Thus we have to do with a modification of the procedure where the width and depth of chest were given by its circumference (mesosternale). The reason which made this modification interesting for us was in that the measurement of the transverse and sagittal diameter of the chest did not depend--when compared with the chest circumference measurement--so much on the muscular and fat tissue of the human body.

Modified allometric function in the body mass forecast.

This paper is a contribution to the problem of an optimum forecast of body mass by means of the skeletal dimensions stature and chest circumference. Application of the basic equation valid for allometric functions made it possible to estimate the power of chest circumference in the forecast formula as approximately 1.7 for males and 1.

Sex determination from the hyoid bone by means of discriminant analysis.

Sex diagnosis of skeletal remains represents one of the main problems in the forensic osteological practice. The purpose of the paper was to apply discriminant analysis as the method of its solution--in the set of measurements carried out on the hyoid bone. Classical procedure by R.

Effect of some drugs, experimental stress and estrus on unstable and fixed conditioned alimentary motor reflexes in cats. Meclophenoxate, chlorprothixen, caffeine, piracetam. Part VI.

A group of 10 cats, both sexes, were studied for the effect of peroral administration of the meclophenoxate (Cetrexin, Léciva, 1.5 mg kg-1) + chlorprothixen (Chlorprothixen, Spofa, 0.045 mg kg-1) + caffeine (Coffeinum natrium benzoicum, Spofa, 0.

Effect of some drugs, experimental stress and estrus on unstable and fixed conditioned alimentary motor reflexes in cats. Reproduction and stress. Part V.

Reproduction of fixed conditioned alimentary motor reflexes in long-time laboratory kept cats in the course of the year is remarkably influenced by the sexual cycle. Estrus, anestrus, gestation and deliveries act upon the reflex reproduction in a similar way like deliberate application of experimental stress of various intensity. The study of the antistress efficacy of drugs modifying psychological functions and mental states in the method of reproduction of fixed alimentary motor reflexes under stress must specify the actual effect of experimental stress.

Reliability of the body mass prediction by means of indices.

By the body mass indices the density is given, human body has in some abstract skeletal space. This skeletal space has been delimited by means of stature and chest circumference of the subject; these indices can serve not only as the characteristics of body composition, but also as a tool through which the body mass is to evaluate, adequate to the given skeletal space. Eight body mass indices of this kind have been introduced and the prediction formulas studied in our previous papers; besides it the procedure of computation of the prediction reliability has been derived, based on the mean square deviation between the actual and predicted values of body mass in the reference set of subjects.

Sample entropy and uniformity of distractors functioning in the achievement test.

This paper completes knowledge of the theoretical probability distribution of the sample entropy under the hypothesis that the distractors operate uniformly as a basis for the statistical test of this hypothesis.

Acute effects of ethanol (0.5 mg/kg) and its interaction with diazepam (5 mg) and meclophenoxate (100 mg) on the blood pressure, the body temperature and the heart rate in man.

1. In the course of an experiment in which acute effects of perorally applied ethanol alone (0.5 g/kg of body weight) or in combination with diazepam (5 mg) and meclophenoxate (100 mg) on verbal learning were studied, the values of the blood pressure, the body temperature and the heart rate of experimental subject were simultaneously registered with the help of polyphysiograph Physiomat.

On acute effects of some drugs on the higher nervous activity in man. Ethanol (0.5 g/kg) and its interaction with diazepam (5 mg) and meclophenoxate (100 mg). Part LVIII.

1. Acute effects of ethanol (0.5 g/kg of body weight) and its interactions with diazepam (5 mg) and meclophenoxate (100 mg) and placebo on the higher nervous activity were tested on a group of 16 healthy and unfatigued volunteers-university students (8 females, 8 males, aged 21 years).

Body mass indices based on the chest diameters.

There is a series of indices used in the physical anthropology by means of which human body mass is related to some dimensions or functions of dimensions of the skeleton. Physical dimension of these indices is that of the density - in the lengths, surfaces or volumes. Among those functions also the cylinder is considered the height of which coincides with that of the body and the circumference of which is the same as the chest circumference.